Results 81 to 90 of about 461,287 (304)

Vitamin E supplementation and increased risk of gestational hypertension and preeclampsia in women undergoing assisted reproductive technologies

Chinese Medical Journal
. Background:. Existing literature regarding the influence of vitamin E (VE) supplementation on the risk of gestational hypertension (GH) and preeclampsia (PE) remains controversial.
Xiaolin Yang, Yuanyan Dou, Lingmin Hu, Xiao Zhang, Liya Pang, Yangqian Jiang, Hong Lv, Lei You, Shuifang Lei, Kang Ke, Tianyu Sun, Haowen Zhang, Xiumei Han, Bo Xu, Kun Zhou, Xiaoyu Liu, Ye Ding, Tao Jiang, Jiangbo Du, Xiufeng Ling, Hongxia Ma, Yuan Lin, Zhibin Hu, Jing Ni   +23 more
doaj   +1 more source

Maternal environment shapes the life history and susceptibility to malaria of Anopheles gambiae mosquitoes. [PDF]

, 2011
BACKGROUND: It is becoming generally recognized that an individual's phenotype can be shaped not only by its own genotype and environmental experience, but also by its mother's environment and condition.
Koella, Jacob C, Koella Jacob C, Lorenz, Lena M, Lorenz Lena M, Jacob C Koella, Lena M Lorenz   +5 more
core   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Distinct molecular properties and functions of small EV subpopulations isolated from human umbilical cord MSCs using tangential flow filtration combined with size exclusion chromatography

Journal of Extracellular Vesicles
As functional derivatives of mesenchymal stem cells (MSCs), small extracellular vesicles (sEVs) have garnered significant attention and application in regenerative medicine.
Wei Liu, Xinyu Wang, Yating Chen, Jiapei Yuan, Huiyu Zhang, Xin Jin, Yuying Jiang, Junjing Cao, Zibin Wang, Shuo Yang, Bingwei Wang, Tinghe Wu, Jing Li   +12 more
doaj   +1 more source

Intergenerational 20 year trends in the prevalence of asthma and hay fever in adults: the Midspan family study surveys of parents and offspring [PDF]

, 2000
<b>Objective</b>: To estimate trends between 1972-6 and 1996 in the prevalences of asthma and hay fever in adults. Design: Two epidemiological surveys 20 years apart.
McConnachie, A., Upton, M.N., McSharry, C., Davey Smith, G., Hart, C.L., Watt, G.C.M., Gillis, C.R.   +6 more
core   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Optimization of in vivo delivery methods and their applications in seminiferous tubules of mice

BMC Biotechnology
This study aims to explore and optimize the conditions for in vivo transfection and gene editing, emphasizing their potential applications in the treatment of infertility in mice.
Xinyuan Dai, Fangzhu Wang, Siting Wang
doaj   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Deconvolution at the single-cell level reveals ovarian cell-type-specific transcriptomic changes in PCOS

Reproductive Biology and Endocrinology
Background Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders in females of childbearing age. Various types of ovarian cells work together to maintain normal reproductive function, whose discordance often takes ...
Shumin Li, Yimeng Li, Yu Sun, Gengchen Feng, Ziyi Yang, Xueqi Yan, Xueying Gao, Yonghui Jiang, Yanzhi Du, Shigang Zhao, Han Zhao, Zi-Jiang Chen   +11 more
doaj   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source