Results 91 to 100 of about 911,118 (353)

Interaction between Prenatal and Postnatal Exposure to High-Fructose Corn Syrup Increases Gene Expression of <i>Tnfa</i> in Hippocampus of Offspring

, 2023
Mirai Yamazaki, Hiroya Yamada, Eiji Munetsuna, Yoshitaka Ando, Itsuki Kageyama, Nao Sadamoto, Yuki Nouchi, Atsushi Teshigawara, Genki Mizuno, Hiroaki Ishikawa, Koji Suzuki, Shuji Hashimoto, Koji Ohashi   +12 more
openalex   +2 more sources

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Crosstalk between H3K4me3 and oxidative stress is a potential target for the improvement of ART-derived embryos

Nature Communications
With the advent and development of assisted reproductive technology (ART), more and more people affected by infertility have been able to obtain offspring successfully. Nevertheless, various adverse outcomes have been found to be associated with ART, and
Chuanxin Zhang, Hao Tian, Xiaoyu Yin, Xueqi Dong, Ning Wang, Yiwen Zhang, Jiawei Wang, Jinzhu Song, Cheng Li, Zi-Jiang Chen, Boyang Liu, Keliang Wu   +11 more
doaj   +1 more source

Why We Should Create Artificial Offspring: Meaning and the Collective Afterlife [PDF]

, 2018
This article argues that the creation of artificial offspring could make our lives more meaningful. By ‘artificial offspring’ I mean beings that we construct, with a mix of human and non-human-like qualities.
Danaher, John
core  

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Association between endometrial thickness and cumulative live birth rate in one oocyte-retrieval cycle: a retrospective cohort study including 26,127 patients

BMC Pregnancy and Childbirth
Background This retrospective study aimed to evaluate the association between endometrial thickness (EMT) on the day of human chorionic gonadotropin (hCG) trigger and the cumulative live birth rate (CLBR) across one oocyte-retrieval cycle.
Gege Ouyang, Huiying Xiao, Ning Li, Yue Niu, Yuan Fang, Jialin Zou, Dingying Zhao, Daimin Wei   +7 more
doaj   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Growth differentiation factor 11 regulates high glucose-induced cardiomyocyte pyroptosis and diabetic cardiomyopathy by inhibiting inflammasome activation

Cardiovascular Diabetology
Background Diabetic cardiomyopathy (DCM) is a crucial complication of long-term chronic diabetes that can lead to myocardial hypertrophy, myocardial fibrosis, and heart failure.
Jing Zhang, Guolong Wang, Yuxuan Shi, Xin Liu, Shuang Liu, Wendi Chen, Yunna Ning, Yongzhi Cao, Yueran Zhao, Ming Li   +9 more
doaj   +1 more source

Examining the reversibility of long-term behavioral disruptions in progeny of maternal SSRI exposure [PDF]

, 2018
Serotonergic dysregulation is implicated in numerous psychiatric disorders. Serotonin plays widespread trophic roles during neurodevelopment; thus perturbations to this system during development may increase risk for neurodevelopmental disorders ...
Akula, Shyam, Chandler, Krystal, Corbett, Adrian M, Dougherty, Joseph D, Maloney, Susan E, McCullough, Katherine B, McGowin, Audrey E, Rieger, Michael A   +7 more
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source