Results 51 to 60 of about 911,118 (353)

SAT-158 Offspring Exposed to Maternal High Fat Diet Exhibits Systemic Inflammation and Pancreatic Islet Dysfunction [PDF]

, 2019
Offspring born to overweight mothers are more likely to develop dysregulated immune response1, obesity1 and pancreatic islet dysfunction2. These offspring have increased inflammation at birth3 and at least until childhood4. We hypothesize that heightened
Casasnovas, Jose, Jarrell, James, Kua, Kok Lim, Pineros, Annie   +3 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A latent class analysis of parental bipolar disorder: examining associations with offspring psychopathology [PDF]

, 2015
Bipolar disorder (BD) is highly heterogeneous, and course variations are associated with patient outcomes. This diagnostic complexity challenges identification of patients in greatest need of intervention.
Freed, Rachel D., Henin, Aude, Nierenberg, Andrew A., Otto, Michael W., Tompson, Martha C.   +4 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Associations of maternal dietary iron intake during pregnancy with infant neurodevelopment: evidence from a prospective cohort study

Nutrition Journal
Background Iron, an essential micronutrient, plays a critical role in fetal neurodevelopment. Animal studies have demonstrated that maternal iron-deficient diets during pregnancy induce permanent structural and functional alterations in offspring brains.
Rui Qin, Liya Pang, Haiting Hu, Yangqian Jiang, Hong Lv, Kan Ye, Cong Liu, Xin Xu, Xiaoyu Liu, Kun Zhou, Tao Jiang, Jiangbo Du, Lingmin Hu, Zhibin Hu, Zhonghua Shi, Yuan Lin   +15 more
doaj   +1 more source

Relative costs of offspring sex and offspring survival in a polygynous mammal [PDF]

Biology Letters, 2016
Costs of reproduction are expected to be ubiquitous in wild animal populations and understanding the drivers of variation in these costs is an important aspect of life-history evolution theory. We use a 43 year dataset from a wild population of red deer to examine the relative importance of two factors that influence the costs of reproduction to ...
Froy, Hannah, Walling, Craig A, Pemberton, Josephine M, Clutton-Brock, Tim H, Kruuk, Loeske EB   +4 more
openaire   +4 more sources

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

WDR36 Regulates Trophectoderm Differentiation During Human Preimplantation Embryonic Development Through Glycolytic Metabolism

Advanced Science
Mammalian pre‐implantation development is a complex process involving sophisticated regulatory dynamics. WD repeat domain 36 (WDR36) is known to play a critical role in mouse early embryonic development, but its regulatory function in human embryogenesis
Shiyu An, Shuyue Hou, Feifei Xu, Huanyu Yan, Wenyi Zhang, Jinfeng Xiang, Haoran Chen, Hanwen Zhang, Lingling Dong, Xiaobin Sun, Ran Huo, Yun Chen, Xi Wang, Yang Yang   +13 more
doaj   +1 more source

Vitamin E supplementation and increased risk of gestational hypertension and preeclampsia in women undergoing assisted reproductive technologies

Chinese Medical Journal
. Background:. Existing literature regarding the influence of vitamin E (VE) supplementation on the risk of gestational hypertension (GH) and preeclampsia (PE) remains controversial.
Xiaolin Yang, Yuanyan Dou, Lingmin Hu, Xiao Zhang, Liya Pang, Yangqian Jiang, Hong Lv, Lei You, Shuifang Lei, Kang Ke, Tianyu Sun, Haowen Zhang, Xiumei Han, Bo Xu, Kun Zhou, Xiaoyu Liu, Ye Ding, Tao Jiang, Jiangbo Du, Xiufeng Ling, Hongxia Ma, Yuan Lin, Zhibin Hu, Jing Ni   +23 more
doaj   +1 more source

Effects of Feeding Bt Maize to Sows during Gestation and Lactation on Maternal and Offspring Immunity and Fate of Transgenic Material [PDF]

, 2012
peer-reviewedBackground: We aimed to determine the effect of feeding transgenic maize to sows during gestation and lactation on maternal and offspring immunity and to assess the fate of transgenic material.
Buzoianu, Stefan G., Gardiner, Gillian E., Gelencser, Eva, Lawlor, Peadar G, Nagy, Andras, O'Donovan, Orla, Rea, Mary, Ross, R Paul, Szabo, Erika, Ujhelyi, Gabriella, Walsh, Maria C.   +10 more
core   +2 more sources