Phase-separated CCER1 coordinates the histone-to-protamine transition and male fertility
Nature Communications, 2023 Idiopathic fertility disorders are associated with mutations in various genes. Here, we report that coiled-coil glutamate-rich protein 1 (CCER1), a germline-specific and intrinsically disordered protein (IDP), mediates postmeiotic spermatid ...
Dongdong Qin +16 more
doaj +1 more source
Maternal obesity has little effect on the immediate offspring but impacts on the next generation [PDF]
, 2013 Maternal obesity during pregnancy has been linked to an increased risk of obesity and cardiometabolic disease in the offspring, a phenomenon attributed to developmental programming. Programming effects may be transmissible across generations through both
Dakin, Rachel S. +7 more
core +1 more source
Rnf32 is not essential for spermatogenesis and male fertility in mice [PDF]
PeerJBackground Ring finger motifs are found in a variety of proteins with diverse functions, often involved in protein-DNA or protein–protein interactions.
Hao Kong +4 more
doaj +2 more sources
The association of maternal prenatal psychosocial stress with vascular function in the child at age 10-11 years: findings from the Avon longitudinal study of parents and children [PDF]
, 2013 Objective To investigate whether (1) maternal psychosocial stress (depression/anxiety) during pregnancy is associated with offspring vascular function and (2) whether any association differs depending on the gestational timing of exposure to stress.
Dawe, K +6 more
core +2 more sources
Gut Microbes, 2023 Women’s health encompasses life-course healthcare, and mounting evidence emphasizes the pivotal contribution of gut microbiota. Therefore, understanding the temporal dynamics of gut microbiota and how age influences disease-gut microbiota associations is
Chao Dong +7 more
doaj +1 more source
Metabolic effects of a high-fat diet post-weaning after low maternal dietary folate during pregnancy and lactation [PDF]
, 2014 Scope Investigate the influence of low-folate supply during pregnancy and lactation on obesity and markers of the metabolic syndrome in offspring, and how provision of a high-fat diet post weaning may exacerbate the resultant phenotype.
Ford, Dianne +6 more
core +1 more source
Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring [PDF]
, 2009 Background miRNAs play important roles in the regulation of gene functions. Maternal dietary modifications during pregnancy and gestation have long-term effects on the offspring, but it is not known whether a maternal high fat (HF) diet during ...
Bruce, Kimberley D. +9 more
core +3 more sources
Managing \u27shades of grey\u27: a focus group study exploring community-dwellers’ views on advance care planning in older people [PDF]
, 2017 Background: Community-dwelling consumers of healthcare are increasing, many aging with life-limiting conditions and deteriorating cognition. However, few have had advance care planning discussions or completed documentation to ensure future care ...
Michael, N, O\u27Callaghan, C, Sayers, E
core +2 more sources
Intergenerational change and familial aggregation of body mass index [PDF]
, 2011 The relationship between parental BMI and that of their adult offspring, when increased adiposity can become a clinical issue, is unknown. We investigated the intergenerational change in body mass index (BMI) distribution, and examined the sex-specific ...
AG Barnett +20 more
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Respite and repair: how mothers of incarcerated long-term problematic drug users make prison work for them [PDF]
, 2016 This article considers the way a group of mothers experienced the incarceration of their problematic drug using offspring. The offspring had been imprisoned for a range of offences including theft, burglary and drug dealing with the root cause of their ...
Cartwright, Luke
core +1 more source