Results 91 to 100 of about 27,515 (197)

磷酸化Smad3在神经元样细胞氧糖剥夺中的表达变化

Zhongguo shiyan zhenduanxue, 2015
目的探讨磷酸化Smad3蛋白在神经元样PC12细胞氧糖剥夺中的表达变化。方法利用鼠神经生长因子（NGF）诱导大鼠嗜铬细胞瘤细胞（PC12）向神经元样细胞转化,应用无糖DMEM培养液联合连二亚硫酸钠（Na2S2O4）构建氧糖剥夺模型（oxygen-glucose deprivation,OGD）,体外模拟神经元缺血性损伤。MTT检测神经元样细胞OGD 0,3,6和12h存活率,Western blot检测OGD前后磷酸化Smad3蛋白表达。结果成功建立神经元样PC12细胞的OGD模型;OGD ...
徐仲航, 王一鸣, 王勇涛, 王姣琦, 何金婷, 莽靖, 邵延坤, 徐忠信   +7 more
doaj  

A Gap Analysis Framework for an Open Data Portal Assessment Based on Data Provision and Consumption Activities

Informatics
An Open Government Data (OGD) portal assessment is necessary to track and monitor the progress of the OGD initiative and to drive improvement. Although OGD benchmarks typically focus on assessing and ranking OGD portals, few have been developed ...
Sahaporn Sripramong, Chutiporn Anutariya, Patipat Tumsangthong, Theerawat Wutthitasarn, Marut Buranarach   +4 more
doaj   +1 more source

The selective antagonism of P2X7 and P2Y1 receptors prevents synaptic failure and affects cell proliferation induced by oxygen and glucose deprivation in rat dentate gyrus.

PLoS ONE, 2014
Purinergic P2X and P2Y receptors are broadly expressed on both neurons and glial cells in the central nervous system (CNS), including dentate gyrus (DG).
Giovanna Maraula, Daniele Lana, Elisabetta Coppi, Francesca Gentile, Tommaso Mello, Alessia Melani, Andrea Galli, Maria Grazia Giovannini, Felicita Pedata, Anna Maria Pugliese   +9 more
doaj   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, Volume 13, Issue 8, 9 February 2026.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Cerebral ischemia‐reperfusion injury (CIRI) is a key pathological process limiting the efficacy of stroke therapy. This study has developed an innovative, multifunctional, brain‐targeted nanoplatform (RFP) containing MXene nanoenzymes and ferroptosis inhibitors.
Lu Wang, Chao Hou, Shuo Li, Lizhi Yang, Yiqun Lin, Sen Wang, Xiaohua Jia, Hui Hui, Wen He, Wei Zhang   +9 more
wiley   +1 more source

Tracking the Evolution of OGD Portals: A Maturity Model [PDF]

, 2017
Since its inception, open government data (OGD) as a free re-useable object has attracted the interest of researchers and practitioners, civil servants, citizens and businesses for different reasons in each target group. This study was designed to aggregate the research outcomes and developments through the recent years towards illustrating the ...
Alexopoulos, Charalampos, Diamantopoulou, Vasiliki, Charalabidis, Yannis   +2 more
openaire   +2 more sources

Characterizing TDP‐43 involvement in vascular dementia

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Vascular dementia (VaD) is a major therapeutic challenge. Tar DNA‐binding protein 43 (TDP‐43), known for its role in neurodegeneration, may contribute to VaD pathogenesis under chronic cerebral hypoperfusion (CCH). This study investigates TDP‐43 dysregulation in VaD.
Marconi Fung, Yuek Ling Chai, Yi‐Lin Cheng, Nishat Tabassum, Vernise J. T. Lim, Raj N. Kalaria, Dong‐Gyu Jo, Christopher P. Chen, Mitchell K. P. Lai, Thiruma V. Arumugam   +9 more
wiley   +1 more source

KCC2 Dysfunction Mediated by Microglial BDNF/TrkB Signaling Exacerbates Early Post‐Stroke Seizure Susceptibility

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Ischemic stroke induces microglial activation and BDNF–TrkB signaling, leading to KCC2 downregulation and seizure susceptibility. Pharmacological inhibition of microglia or TrkB and restoration of KCC2 function with the chloride extrusion enhancer CLP290 attenuate post‐ischemic seizures.
Jing Zhou, Benjamin H. Wang, Jiangning Yu, Guoxiang Wang, Jingyi Cai, Mohan Yu, Kehua Chen, Li Wan, Xu Liu, Zhigang Yang, Yulong Wang, Yun Wang   +11 more
wiley   +1 more source

Selenocysteine antagonizes oxygen glucose deprivation-induced damage to hippocampal neurons

Neural Regeneration Research, 2018
Designing and/or searching for novel antioxidants against oxygen glucose deprivation (OGD)-induced oxidative damage represents an effective strategy for the treatment of human ischemic stroke.
Xian-Jun Wang, Mei-Hong Wang, Xiao-Ting Fu, Ya-Jun Hou, Wang Chen, Da-Chen Tian, Su-Yun Bai, Xiao-Yan Fu   +7 more
doaj   +1 more source

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés, Enrique Lima, Lorena Duarte‐Peña, Sheila I. Peña‐Corona, Zainab M. Almarhoon, Rajesh Kaverikana, Shivaprasad Shetty Mangalpady, Vinayaka Babu Shet, Nikshitha Manjeshwar, Javad Sharifi‐Rad, Jen‐Tsung Chen, Gerardo Leyva‐Gómez, William N. Setzer, Daniela Calina   +13 more
wiley   +1 more source