Results 11 to 20 of about 14,327 (215)

Crosstalk between m6A mRNAs and m6A circRNAs and the time-specific biogenesis of m6A circRNAs after OGD/R in primary neurons

Epigenetics, 2023
Cerebral ischaemiareperfusion injury is an important pathological process in nervous system diseases during which neurons undergo oxygenglucose deprivation and reoxygenation (OGD/R) injury.
Chi Zhang, Huan Jian, Shenghui Shang, Lu Lu, Yongfu Lou, Yi Kang, Hong Bai, Zheng Fu, Yigang Lv, Xiaohong Kong, Xueying Li, Shiqing Feng, Hengxing Zhou   +12 more
doaj   +2 more sources

Anisomycin prevents OGD-induced necroptosis by regulating the E3 ligase CHIP [PDF]

Scientific Reports, 2020
AbstractNecroptosis is an essential pathophysiological process in cerebral ischemia-related diseases. Therefore, targeting necroptosis may prevent cell death and provide a much-needed therapy. Ansiomycin is an inhibitor of protein synthesis which can also activate c-Jun N-terminal kinases.
Congli Mao, M.-B. Tang, Z.-W. Hu, Yingwu LI, Y. Cheng, J.C. Schisler, Chenyang Shi, S.-H. Li, S. Zhang, Y.-M. Xu, H.-Y. Luo   +10 more
openalex   +3 more sources

Identification of blood-brain barrier injury-related biomarkers in cerebral infarction using transcriptomic analysis [PDF]

Scientific Reports
Background Cerebral infarction leads to blood-brain barrier (BBB) disruption, exacerbating brain injury through edema, inflammation, and neuronal death. Although BBB damage is a critical event in stroke pathology, the underlying molecular mechanisms and ...
Xiaoyan Liu, Yu He, Nannan Zhang, Yulan Cai, Chuyu Liu   +4 more
doaj   +2 more sources

Factors Influencing Practitioners’ Experience of Utilizing Open Government Data [PDF]

Journal of Library and Information Studies, 2023
Open government data (OGD) has been discussed globally for its value in improving the government’s service quality and transparency. However, most OGD must be utilized by the practitioners in their projects so that the public can benefit from the ...
Wei-Chung Cheng, Ming-Hsin Phoebe Chiu
doaj   +1 more source

Correlation between granulocyte colony-stimulating factor and the Notch signaling pathway in ischemic brain injury

Archives of Medical Science, 2021
Introduction This study aimed to determine the relationship between granulocyte colony-stimulating factor (G-CSF) and the Notch signaling pathway in ischemic brain injury.
Ning Xie, Qin Huang, Jingting Han, Wenyuan Xu   +3 more
doaj   +1 more source

Complete inhibition of phosphatase and tensin homolog promotes the normal and oxygen-glucose deprivation/reperfusion-injured PC12 cells to cell death [PDF]

Journal of Cardiovascular and Thoracic Research, 2018
Introduction: Lipid phosphatase and tensin homolog deleted from chromosome 10 (PTEN) antagonizes phosphoinositide 3-kinase (PI3K)/AKT cell survival pathway.
Sohrab Minaei Beyrami, Mohammad Hasan Khadem Ansari, Yousef Rasemi, Nader Shakib, Pouran Karimi   +4 more
doaj   +1 more source

Physiologically‐based pharmacokinetic modeling to support bioequivalence and approval of generic products: A case for diclofenac sodium topical gel, 1%

CPT: Pharmacometrics & Systems Pharmacology, 2021
Establishing bioequivalence (BE) for dermatological drug products by conducting comparative clinical end point studies can be costly and the studies may not be sufficiently sensitive to detect certain formulation differences.
Eleftheria Tsakalozou, Andrew Babiskin, Liang Zhao   +2 more
doaj   +1 more source

Regulatory utility of physiologically‐based pharmacokinetic modeling to support alternative bioequivalence approaches and risk assessment: A workshop summary report

CPT: Pharmacometrics & Systems Pharmacology, 2023
This report summarizes the proceedings for day 2 sessions 1 and 3 of the 2‐day public workshop entitled “Regulatory Utility of Mechanistic Modeling to Support Alternative Bioequivalence Approaches,” a jointly sponsored workshop by the US Food and Drug ...
Fang Wu, Youssef Mousa, Kimberly Raines, Chris Bode, Yu Chung Tsang, Rodrigo Cristofoletti, Hongling Zhang, Tycho Heimbach, Lanyan Fang, Filippos Kesisoglou, Amitava Mitra, James Polli, Myong‐Jin Kim, Jianghong Fan, Banu S. Zolnik, Duxin Sun, Yi Zhang, Liang Zhao   +17 more
doaj   +1 more source

Modified Oesophago-Gastric Dissociation (M-OGD) — a technical modification [PDF]

Updates in Surgery, 2020
AbstractAdhesions and fibrosis following failed primary surgery for severe gastro-oesophageal reflux (GOR) in neurologically impaired children (NI) can render mobilization of the lower oesophagus and oesophago-jejunal anastomosis a technically demanding exercise both at open surgery and laparoscopy.
Coletta R., Mussi E., Bianchi A., Morabito A.   +3 more
openaire   +3 more sources

Cell death pathways in astrocytes with a modified model of oxygen-glucose deprivation. [PDF]

PLoS ONE, 2013
Traditional oxygen-glucose deprivation (OGD) models do not produce sufficiently stable and continuous deprivation to induce cell death in the ischemic core.
Qiaoying Huang, Rui Zhang, Liang yu Zou, Xu Cao, Xiaofan Chu   +4 more
doaj   +1 more source