Results 51 to 60 of about 28,063 (214)

CLIP-OGD: An Experimental Design for Adaptive Neyman Allocation in Sequential Experiments

Advances in Neural Information Processing Systems 36, 2023
From clinical development of cancer therapies to investigations into partisan bias, adaptive sequential designs have become increasingly popular method for causal inference, as they offer the possibility of improved precision over their non-adaptive counterparts. However, even in simple settings (e.g.
Jessica Dai, Paula Gradu, Christopher Harshaw   +2 more
openaire   +3 more sources

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Operational Discord Measure for Gaussian States with Gaussian Measurements

, 2015
We introduce an operational discord-type measure for quantifying nonclassical correlations in bipartite Gaussian states based on using Gaussian measurements. We refer to this measure as operational Gaussian discord (OGD).
Caves, Carlton M., Rahimi-Keshari, Saleh, Ralph, Timothy C.   +2 more
core   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Prolonged astrocyte-derived erythropoietin expression attenuates neuronal damage under hypothermic conditions

Journal of Neuroinflammation, 2020
Background Hypoxic-ischemic encephalopathy (HIE) has a high morbidity rate and involves severe neurologic deficits, including cerebral palsy. Therapeutic hypothermia (TH) has been shown to decrease the mortality rate and provide neuroprotection in ...
Kohki Toriuchi, Hiroki Kakita, Tetsuya Tamura, Satoru Takeshita, Yasumasa Yamada, Mineyoshi Aoyama   +5 more
doaj   +1 more source

Orthogonal Bases of Invariants in Tensor Models [PDF]

, 2017
Representation theory provides a suitable framework to count and classify invariants in tensor models. We show that there are two natural ways of counting invariants, one for arbitrary rank of the gauge group and a second, which is only valid for large N.
A Einstein, A Jevicki, D Bekker, J Polchinski, MW Hero, Pablo Diaz, R Bhattacharyya, R Bhattacharyya, R Gurau, R Gurau, R Mello Koch de, R Mello Koch de, Soo-Jong Rey, SR Das, TW Brown, V Balasubramanian, V Comarmond De, Y Kimura, Y Kimura   +18 more
core   +2 more sources

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Neuroglobin overexpression inhibits oxygen–glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons

Neurobiology of Disease, 2013
Neuroglobin (Ngb) is an endogenous neuroprotective molecule against hypoxic/ischemic brain injury, but the underlying mechanisms remain largely undefined.
Zhanyang Yu, Ning Liu, Yadan Li, Jianfeng Xu, Xiaoying Wang   +4 more
doaj   +1 more source

Time trend occurrence of duodenal intraepithelial lymphocytosis and celiac disease in an open access endoscopic population [PDF]

, 2017
Background: Duodenal intraepithelial lymphocytosis (DIL) is a histological finding characterized by the increase of intraepithelial CD3T-lymphocytes over the normal value without villous atrophy, mostly associated to coeliac disease (CD), Helicobacter ...
Annibale, B., Corleto, Vd, Di Giulio, E, Galli, G, Lahner, E, Pilozzi, E, Purchiaroni, F, Sacchi, Mc   +7 more
core   +2 more sources

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source