Results 181 to 190 of about 11,397 (216)

OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts. [PDF]

Nat Commun
De Rosa M, Barnes RP, Detwiler AC, Nyalapatla PR, Wipf P, Opresko PL.   +5 more
europepmc   +1 more source

Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy. [PDF]

Cells
Piscone A, Gorini F, Ambrosio S, Noviello A, Scala G, Majello B, Amente S.   +6 more
europepmc   +1 more source

Contributing factors to the oxidation-induced mutational landscape in human cells. [PDF]

Nat Commun
Cordero C, Mehta KPM, Weaver TM, Ling JA, Freudenthal BD, Cortez D, Roberts SA.   +6 more
europepmc   +1 more source

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TH5487, a small molecule inhibitor of OGG1, attenuates pulmonary fibrosis by NEDD4L-mediated OGG1 degradation

Chemico-Biological Interactions, 2022
Pulmonary fibrosis is a highly aggressive and lethal disease that currently lacks effective targeting therapies. Herein, we established a mouse model of pulmonary fibrosis induced by intratracheal instillation of bleomycin (BLM) in wild-type (WT) and 8-oxoguanine DNA glycosylase-1 (OGG1) knockout (Ogg1-/-) mice.
Huayu Ling, Chuge Song, Yaowei Fang, Yu Yin, Zijun Wu, Yahong Wang, Zhiliang Xu, Shenglan Gao, Ao Li, Gang Liu   +9 more
openaire   +2 more sources

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress [PDF]

Nucleic Acids Research, 2020
AbstractAltered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguanine-DNA glycosylase (OGG1) to recognise and excise 8-oxoG.
Torkild Visnes, Ana Osorio, Armando Cázares-Körner   +2 more
exaly   +7 more sources

A functional OGG1 homologue from Arabidopsis thaliana

Molecular Genetics and Genomics, 2001
One of the major mutagenic base lesions in DNA caused by exposure to reactive oxygen species is 7,8-dihydro-8-oxoguanine (8-oxoG). Genes coding for DNA repair enzymes that recognise 8-oxoG have been reported in bacteria, yeast, mammals and plants. The prokaryotic and eukaryotic genes are functional homologues but differ in their primary sequence.
A L, Dany, A, Tissier
openaire   +2 more sources

OGG1 is essential in oxidative stress induced DNA demethylation

Cellular Signalling, 2016
DNA demethylation is an essential cellular activity to regulate gene expression; however, the mechanism that triggers DNA demethylation remains unknown. Furthermore, DNA demethylation was recently demonstrated to be induced by oxidative stress without a clear molecular mechanism.
Lingfeng He, Yan Cao, Fei-Yan Pan
exaly   +3 more sources

Tuberin regulates the DNA repair enzyme OGG1

American Journal of Physiology-Renal Physiology, 2008
The tuberous sclerosis complex (TSC) is caused by defects in one of two tumor suppressor genes, TSC-1 or TSC-2. The TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors, both angiomyolipomas and renal cell carcinomas. We investigated a potential role for tuberin in regulating a key DNA repair pathway.
Samy L, Habib, Daniel J, Riley, Lenin, Mahimainathan, Basant, Bhandari, Goutam Ghosh, Choudhury, Hanna E, Abboud   +5 more
openaire   +2 more sources

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells [PDF]

Nature, 2007
Although oxidative damage has long been associated with ageing and neurological disease, mechanistic connections of oxidation to these phenotypes have remained elusive. Here we show that the age-dependent somatic mutation associated with Huntington's disease occurs in the process of removing oxidized base lesions, and is remarkably dependent on a ...
Yuan Liu, Arne Klungland, Samuel H Wilson   +2 more
exaly   +3 more sources

Structure and chromosome location of human OGG1

Cytogenetic and Genome Research, 1999
OGG1 (alias MMH) encodes an 8-hydroxyguanine glycosylase, functionally homologous to bacterial mutM. Here, we report its genomic structure and fine chromosome location. The human OGG1 gene corresponding to the isoform 1 transcripts, consists of seven exons, spanning 7,421 bps, while an alternative additional exon, utilized for isoform 2, is located ...
T, Ishida, Y, Hippo, Y, Nakahori, I, Matsushita, T, Kodama, S, Nishimura, H, Aburatani   +6 more
openaire   +2 more sources