Results 191 to 200 of about 11,397 (216)
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Circulation, 2014
Introduction: Reactive oxygen species (ROS) play a key role in the development of atherosclerosis. Mitochondria are a main source of endogenous ROS in the cell. Mitochondrial DNA (mtDNA) is sensitive to oxidation and our previous results from cultured cell and intact animal models suggest that increasing mtDNA repair prevents ...
Mykhaylo V Ruchko +6 more
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Introduction: Reactive oxygen species (ROS) play a key role in the development of atherosclerosis. Mitochondria are a main source of endogenous ROS in the cell. Mitochondrial DNA (mtDNA) is sensitive to oxidation and our previous results from cultured cell and intact animal models suggest that increasing mtDNA repair prevents ...
Mykhaylo V Ruchko +6 more
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OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos [PDF]
Cell Death and Disease, 2018 AbstractOxidative stress-induced DNA damage has been well acknowledged as a major cause leading to cell death, which is etiologically linked to ischemic injury and degenerative alterations. The most common oxidation product of DNA is base lesion 8-oxo-7,8-dihydroguanine (8-oxoG), which is repaired by 8-oxoG glycosylase1 (OGG1)-initiated baseexcision ...
Ruoxi Wang, Xianlu Zeng, Istvan Boldogh
exaly +3 more sources
Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1) [PDF]
ACS Chemical Biology, 2015 The DNA base excision repair (BER) pathway, which utilizes DNA glycosylases to initiate repair of specific DNA lesions, is the major pathway for the repair of DNA damage induced by oxidation, alkylation, and deamination. Early results from clinical trials suggest that inhibiting certain enzymes in the BER pathway can be a useful anticancer strategy ...
Nathan Donley +2 more
exaly +3 more sources
Diabetes, 2019
Mitochondrial DNA (mtDNA) damage heightens mitochondrial oxidative stress, which is very critical for the development of insulin resistance. OGG1 (8-oxoguanine DNA glycosylase-1) is a DNA glycosylase mediating the first step in the base excision repair which removes 7,8-dihydro-8-oxoguanine (8-oxoG) and repairs oxidized nuclear and mtDNA.
LARYSA YUZEFOVYCH, LYUDMILA RACHEK
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Mitochondrial DNA (mtDNA) damage heightens mitochondrial oxidative stress, which is very critical for the development of insulin resistance. OGG1 (8-oxoguanine DNA glycosylase-1) is a DNA glycosylase mediating the first step in the base excision repair which removes 7,8-dihydro-8-oxoguanine (8-oxoG) and repairs oxidized nuclear and mtDNA.
LARYSA YUZEFOVYCH, LYUDMILA RACHEK
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Journal of Biochemical and Molecular Toxicology, 2014
ABSTRACTEight alternatively spliced isoforms of human 8‐oxoguanine DNA glycosylase (OGG1) (OGG1‐1a to ‐1c and ‐2a to ‐2e) are registered in the National Center for Biotechnology Information. OGG1(s) in mitochondria have not yet been fully characterized biochemically.
Akira, Ogawa +3 more
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ABSTRACTEight alternatively spliced isoforms of human 8‐oxoguanine DNA glycosylase (OGG1) (OGG1‐1a to ‐1c and ‐2a to ‐2e) are registered in the National Center for Biotechnology Information. OGG1(s) in mitochondria have not yet been fully characterized biochemically.
Akira, Ogawa +3 more
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Oxidative damage to purines in DNA: Role of mammalian Ogg1
DNA Repair, 2007DNA damage caused by reactive oxygen species is ubiquitous to all living organisms. More than 60 different base lesions have been identified, and the majority of these are removed via the base excision repair pathway. This pathway appears to represent a highly conserved and ancient mechanism of defence counteracting spontaneous DNA decay.
Arne, Klungland, Svein, Bjelland
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OGG1: From Structural Analysis to the Knockout Mouse
2007Among the four DNA bases, guanine, having the lowest redox potential, is the most susceptible to oxidation, and among the oxidized bases 7,8-dihydro-8-oxoguanine (8-oxoG) is certainly the lesion that has retained most attention over many years. This altered base can pair with A as well as C residues during replication.
Arne Klungland +2 more
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[Repair of oxidized guanine in mammals: OGG1 genes].
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1998This paper reviews the present state of the studies on the repair of a major oxydative lesion on DNA, the 8-oxo-guanine (8-OxoG). This modified base has been proved to be highly mutagenic and therefore implicated in the ethiology of several pathologies.
J P, Radicella, S, Boiteux
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