Results 91 to 100 of about 69,580 (257)

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Development of an ointment for burns based in dry extract of the seaweed Fucus spiralis

Frontiers in Marine Science, 2014
The Fucus spiralis is a brown seaweed found on the Portuguese coast used as wound healing in traditional medicine were their antioxidant, immunostimulant, anticoagulant, antibacterial properties and also remineralizing, smoothing, moisturizing capacities
Clélia Neves Afonso
doaj   +1 more source

Comparison of efficacy and safety of 0.005% calcipotriol ointment versus 0.05% betamethasone dipropionate ointment versus calcipotriol plus betamethasone ointment for the treatment of vitiligo

, 2017
Objective To compare the efficacy and safety of calcipotriol ointment versus betamethasone ointment versus calcipotriol plus betamethasone ointment in patients of vitiligo. Methods Patients with vitiligo (n=159) were randomized in three equal groups A, B
Muhammad Saleem Khan, Mahwish Zahoor, Shehla Shaukat, Tahir Jamil Ahmad   +3 more
core   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Study of Consistent Characteristics of the Ointment with Octopirox

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
Effective therapy of seborrheic dermatitis remains an actual task for the dermatological practice. Octopirox has a significant antimycotic activity and a wide spectrum of antibacterial effect both against gram-negative and gram-positive pathogenic ...
V. A. Solodovnyk, V. V. Hladyshev, A. P. Lysianska   +2 more
doaj   +1 more source

Effects of aural stimulation with capsaicin ointment on swallowing function in elderly patients with non-obstructive dysphagia

, 2014
Eiji Kondo,1,2 Osamu Jinnouchi,3 Hiroki Ohnishi,3 Ikuji Kawata,3 Seiichi Nakano,2 Masakazu Goda,1 Yoshiaki Kitamura,1 Koji Abe,1 Hiroshi Hoshikawa,4 Hidehiko Okamoto,5 Noriaki Takeda1 1Department of Otolaryngology, University of Tokushima School of ...
Kondo E, Ohnishi H, Hoshikawa H, Goda M, Okamoto H, Takeda N, Kawata I, Nakano S, Kitamura Y, Jinnouchi O, Abe K   +10 more
core  

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Burke's Ointment

, 2018
Trade card advertising Burke's Ointment, a remedy prepared by the Beeswax Company, Ogdensburg, N ...

core  

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Hair growth activity of formulated ointment based on hydro alcoholic extract of Globularia alypum L: in vivo study

Bulletin of Pharmaceutical Sciences. Assiut University
Globularia alypum L. is a medicinal plant belonging to the Globulariaceae family, widespread in the Mediterranean region and very popular in Algeria. The aim of this study was to evaluate the effect of Globularia alypum L.
Amina BEKARA, Mohammed El Amine BEKARA, Radjaa MEZAINI, Souheyla MEKRAF, Hana BOURKAIB   +4 more
doaj   +1 more source