Results 91 to 100 of about 21,271 (292)

The study of consistent properties of the vasopressin nasal dosage form

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
Evaluation of consistent properties is an important and integral part of investigations on the creation of semisolid nasal pharmacotherapeutic agents. The aim of this work is the study of consistent properties of developed nasal semisolid dosage form ...
Al Nukarii Abdulkarim, A. L. Drozdov, A. P. Lysyanskaya   +2 more
doaj   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Dilution of corticosteroid ointment.

Nishi Nihon Hifuka, 1984
市販の0.025%フルオシノロン·アセトナイド軟膏を, 局方硼酸亜鉛華軟膏, 米国局方白色軟膏, 局方単軟膏, 10%亜鉛華白色軟膏(自家製), 20%亜鉛華単軟膏(サトウザルベ), 5%フルフェナム酸ブチル軟膏(コンベック軟膏)で希釈剤を作り, 血管収縮反応をみると, 希釈剤の別によらず, 2倍·4倍·8倍希釈では100%に, 16倍希釈でも高率に血管収縮がみられた。硼酸亜鉛華軟膏によるフルオシノロン軟膏の2倍および4倍希釈剤を作製し, 原濃度フルオシノロン軟膏と対側療法を行うと, 2倍希釈剤では原濃度のものよりも有効かまたは同等で, 4倍希釈剤では, 同等かまたはこれに劣る。2倍希釈剤を広汎に塗擦すると, 血中11-OHCS, 尿中17-OHCS値の低下がみられ, 全身的影響を無視しえない ...
ASANUMA, Hiroyuki, TAKASHIMA, Iwao, SUDO, Manabu, KUBOTA, Kiyoshi, IJU, Misao   +4 more
openaire   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

THE QUESTION OF DIACHYLON OINTMENT [PDF]

Archives of Dermatology and Syphilology, 1922
A questionnaire recently sent out by a committee on the revision of the Pharmacopeia stirred up the difficult question of diachylon ointment. We answered by saying that we did not employ it, which was technically true, but like answers to most formal questions, was not the exact truth. We employ, and much to our advantage, various substitutes made with
openaire   +2 more sources

New rectal ointments development for local use

, 2012
New rectal ointments for local use with wound healing, antibacterial and haemostatic action were developed. Pharmaceutical compatibility of new ointments components was determined by means of physicochemical analytical methods.Целью настоящей работы ...
Chigvintsev, S. A., Khonina, T. G., Чигвинцев, С. А., Larionov, L. P., Шадрина, Е. В, Ларионов, Л. П., Shadrina, E. V., Хонина, Т. Т.   +7 more
core  

Application and Single‐Cell Regulation Mechanism of Engineered EVs Combined With 4D‐Printed Hydrogel for Infected Burn Repair

Advanced Science, EarlyView.
4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang, Xiaoyan Li, Xiao Xu, Kelun Zhang, Fengjiao Yu, Zhen Shang, Nailong Pan, Junlin Lv, Yiwei Xu, Yan Tang, Liang Zhang, Xiaotong Li, Taoyi Wang, Jing Tao, Jiaxu Song, Mengyu Zhang, Xin Ma, Dan Han, Xiaoying Kong, Wenhua Xu   +19 more
wiley   +1 more source

Formulation and Wound Healing Evaluation in vivo of Ointment Based on Propolis, and Containing Curcumin

Majalah Obat Tradisional
Antimicrobial drugs are widely used in commercial ointments to treat different types of wounds.  Unwise use of antimicrobials in ointment formulations only deepens the problem of antimicrobial resistance.
Mariia Kozak, Kristina Sementsiv, Kristina Sementsiv, Iryna Petruh   +3 more
doaj   +1 more source

Evaluation of some commercial antimicrobial ointments on selected bacterial and fungal strains of clinical importance

, 2020
Background: Antimicrobial ointments are topical products used for the treatment of common skin infections. Potency superiority between certain ointments and creams used in the treatment of skin infections has been a controversial subject among clinicians.
Okunye, O. L., Idowu P. A, Makinde, O. S.   +2 more
core   +1 more source