Results 51 to 60 of about 16,816 (218)
Animal Models and Experimental Medicine, EarlyView.We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp +12 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.To address the limitations of existing models, this study innovatively established a mouse model of endometriosis (EMs) capable of mimicking cyclic bleeding. Our results confirmed that this model recapitulates the complete pathological progression from ectopic lesion establishment to systemic responses, exhibiting superior clinical relevance compared ...
Yu Zhuang +7 more
wiley +1 more source
The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy
Annals of Neurology, EarlyView.Objective Newborn screening (NBS) for spinal muscular atrophy (SMA) facilitates early diagnosis and treatment for affected individuals. However, fluid biomarkers that provide early insights into disease activity and outcomes in a neonatal cohort and those unable to access (due to reimbursement criteria) or deferring immediate treatment are lacking ...
Arlene D'Silva +13 more
wiley +1 more source
Arthroscopy Techniques, EarlyView.Abstract Early meniscal repair and anatomic reconstruction in a multiligament knee injury optimizes outcomes and restores tibiofemoral mechanics. This technique describes a lateral meniscus posterior root and radial tear repair, with concomitant medial ramp repair, performed during single‐stage reconstruction of the anterior cruciate ligament ...
Romir Patel +6 more
wiley +1 more source
Arthroscopy Techniques, EarlyView.Abstract Multiligament knee injuries represent rare and challenging injuries that require complex surgical management to restore stability and function. Current evidence supports anatomic single‐stage reconstructions when feasible in order to re‐establish knee kinematics and enable early rehabilitation.
Logan D. Moews +6 more
wiley +1 more source
Arthroscopy Techniques, EarlyView.Abstract This technical note addresses recurrent patellar instability with a positive J‐sign and describes a minimally invasive, arthroscopic and mini‐open approach that combines medial patellofemoral ligament and medial patellotibial ligament reconstruction with extensive lateral retinacular release, positioned as a preferred or transitional option ...
Zirong Huang +5 more
wiley +1 more source
Arthroscopy Techniques, EarlyView.Abstract Multidirectional shoulder instability, particularly in patients with underlying connective tissue disorders poses a surgical challenge. After exhaustive nonoperative treatment, surgical intervention is focused on restoration of the anterior and inferior capsular restraints.
Mikalyn T. DeFoor +6 more
wiley +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source