Results 131 to 140 of about 3,497 (175)
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Toxicon, 2010
The subcellular distribution of okadaic acid, the main diarrhetic shellfish poisoning (DSP) toxin, in the cells of the digestive gland of the mussel Mytilus galloprovincialis was studied. By means of differential centrifugation, ultrafiltration and extraction with methanol, it was found that most okadaic acid was stored in the cytosol.
Araceli E Rossignoli, Juan Blanco
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The subcellular distribution of okadaic acid, the main diarrhetic shellfish poisoning (DSP) toxin, in the cells of the digestive gland of the mussel Mytilus galloprovincialis was studied. By means of differential centrifugation, ultrafiltration and extraction with methanol, it was found that most okadaic acid was stored in the cytosol.
Araceli E Rossignoli, Juan Blanco
exaly +3 more sources
Okadaic acid in mussels of Adriatic sea
Marine Pollution Bulletin, 1992Abstract The diarrethic shellfish poisoning from mussels, collected in the main producing areas in the seawater off the coast of Emilia-Romagna (Italy), has been investigated. The ether soluble material from hepatopancreas of highly toxic mussels (Mytilus galloprovincialis) was partitioned between n-hexane and methanol-water 9:1.
FATTORUSSO, ERNESTO +8 more
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Esterification of okadaic acid in the mussel Mytilus galloprovincialis
Toxicon, 2011Okadaic acid and other toxins of the diarrheic shellfish poisoning (DSP) group are transformed mainly to their acyl-derivatives in bivalves. Some recent studies suggest that bacteria present in the bivalve gut could contribute substantially to the acylation of the toxins.
Araceli E Rossignoli +2 more
exaly +3 more sources
Biotherapeutic Potential and Synthesis of Okadaic Acid
2000Nature has long provided an array of secondary metabolites that have been utilized by man or humans for a large variety of therapeutic applications. The poly ether marine natural product okadaic acid (OA, Fig. 1) represents a particularly interesting example, with a rich modern history whose drama is continuing to unfold (Scheuer 1995).
C J, Forsyth +3 more
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Okadaic acid augments utrophin in myogenic cells
Neuroscience Letters, 2004Duchenne muscular dystrophy is a fatal childhood disease caused by mutations that abolish the expression of dystrophin in muscle. Utrophin is a paralogue of dystrophin and can functionally replace it in skeletal muscle. A potential therapeutic approach is to increase utrophin levels in muscle.
Marianna, Rodova +2 more
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Okadaic acid (OA): Toxicity, detection and detoxification
Toxicon, 2019Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human embryonic amniotic cells, hepatocytes, neuroblastoma ...
Ling-Ling, Fu +3 more
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Effects of okadaic acid on mouse hemopoietic cells
Biochemical and Biophysical Research Communications, 1989Effects of okadaic acid, a potent non-12-O-tetradecanoyl-phorbol-13-acetate(TPA)-type tumor promoter, on mouse hemopoietic cells were investigated. Okadaic acid stimulated mouse bone marrow cells to form granulocyte-macrophage colony-forming unit (CFU-GM) colonies without added colony stimulating factors(CSFs).
S, Oka +3 more
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2000
Abstract Okadaic acid (OA) is an ionophoric polyether macrocarboxylic acid first isolated from two sponges, Halichondria okadai, which inhabits coastal Japan, and H. melanodocia, a Caribbean sponge found in the Florida Keys (USA) (19).
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Abstract Okadaic acid (OA) is an ionophoric polyether macrocarboxylic acid first isolated from two sponges, Halichondria okadai, which inhabits coastal Japan, and H. melanodocia, a Caribbean sponge found in the Florida Keys (USA) (19).
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Micronucleus induction in mussels exposed to okadaic acid
Toxicon, 2003Some toxins present in the marine environment are capable of inducing mutagenicity and/or carcinogenicity. Among these toxins, okadaic acid (OA) is gaining considerable interest since it induces DNA based modifications at low concentrations and accumulates in filter-feeding marine animals, including those used for human consumption.
C R, Carvalho Pinto-Silva +5 more
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Effects of okadaic acid on the human isolated bronchus
European Journal of Pharmacology, 1994The effects of okadaic acid, a polyether derivative of a 38-carbon monocarboxylic fatty acid obtained from a culture of the marine dinoflagellate, Prorocentrum lima, were studied on the human isolated bronchus. In low concentrations (0.01 and 0.03 microM), okadaic acid had no significant effect of its own on the human isolated bronchus, but in higher ...
E, Naline +7 more
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