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Development of methodologies towards the total synthesis of okadaic acid
, 2017 For the last decades, our laboratory has been interested in the development of new synthetic methodologies and their application to the total syntheses of natural products exhibiting biological activities.
Body, Jean-François
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Okadaic acid, an activator of myosins.
Japanese Journal of Pharmacology, 1991 Kohichi Hayakawa +2 more
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Total Synthesis of Okadaic Acid
Total Synthesis of Okadaic Acid名古屋大学博士学位論文 学位の種類:農学博士 (課程) 学位授与年月日 ...
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Binding competition of okadaic acid derivatives to anti-okadaic acid antibody
Toxicon, 1991The serologic activities of structurally related okadaic acid derivatives have been determined. Binding of [3H]okadaic acid to rabbit anti-okadaic acid is inhibited with equal effectiveness by okadaic acid, dinophysistoxin-1, acanthifolicin, okadaic acid tetramethyl ether, and okadaic acid spiroketal II.
J, Yatsunami +6 more
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Influence of amino acids on okadaic acid production
Toxicon, 2001Okadaic acid (OA) (1)) was the first example of a group of polyether toxins known to be produced by marine microalgae, which are responsible for the natural phenomena known as Diarrhetic Shellfish Poisoning (DSP) red tides. It is also a highly selective inhibitor of protein phosphatases type 1 (PP1) and 2A (PP2A), as well as being a potent tumour ...
M L, Souto +4 more
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Complexation of okadaic acid : A preliminary study
Bioorganic & Medicinal Chemistry Letters, 1998A complexation study was carried out with okadaic acid (OA) and the univalent metal ions Li+, Na+ and K+, and the divalent metal ions Ca2+ and Mg2+. K+ binding was observed identical with a complex obtained from the natural source (OAC). The pharmacological trials demonstrated that this cation has a very important influence on the pharmacological ...
M, Norte +5 more
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Effects of Okadaic Acid on Rat Colon
Digestive Diseases and Sciences, 1998Effects of okadaic acid (OA) on mucosal damage were examined in rat colon. OA was sprinkled on rat colon mucosa under observation with an electronic-endoscopic system, and OA was also applied to the in vivo microscopic field. The OA-induced changes in transepithelial conductance (Gt) were measured by the Ussing voltage clamp technique.
M, Hosokawa +7 more
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Induction of actin cytoskeleton rearrangement by methyl okadaate – comparison with okadaic acid
The FEBS Journal, 2008Methyl okadaate is a derivative of the lipophilic polyether okadaic acid (OA), a well‐known inducer of apoptosis. OA inhibits Ser/Thr protein phosphatases (PPs), among them types 1 and 2A (PP1 and PP2A), whereas methyl okadaate lacks PP1/PP2A inhibitory activityin vitro.
Natalia, Vilariño +6 more
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Effect of Okadaic Acid on Glucose Regulation
Mini-Reviews in Medicinal Chemistry, 2005Okadaic acid is the main toxin responsible for the natural phenomena known as diarrheic shellfish poisoning (DSP). This toxin is a tumor promoter C38 polyether fatty acid that contains acidic and hydrophobic moieties and is cyclic. Okadaic acid is a potent inhibitor of important classes of protein serine/threonine phosphatases such as protein ...
M C, Louzao, M R, Vieytes, L M, Botana
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