Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments [PDF]
, 2003 Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory synaptic transmission and dendritic spine morphology. We report that spinophilin is phosphorylated in vitro by protein kinase A (PKA).
Allen, Patrick B. +5 more
core
Regulation of the Neuron-specific Ras GTPase-activating Protein, synGAP, by Ca2+/Calmodulin-dependent Protein Kinase II [PDF]
, 2004 synGAP is a neuron-specific Ras GTPase-activating protein found in high concentration in the postsynaptic density fraction from mammalian forebrain. Proteins in the postsynaptic density, including synGAP, are part of a signaling complex attached to the ...
Kennedy, Mary B. +2 more
core +1 more source
Is Protein Phosphatase Inhibition Responsible for the Toxic Effects of Okadaic Acid in Animals?
Toxins, 2013 Okadaic acid (OA) and its derivatives, which are produced by dinoflagellates of the genera Prorocentrum and Dinophysis, are responsible for diarrhetic shellfish poisoning in humans.
Rex Munday
doaj +1 more source
Regulated internalization of caveolae [PDF]
, 1994 Caveolae are specialized invaginations of the plasma membrane which have been proposed to play a role in diverse cellular processes such as endocytosis and signal transduction.
Joggerst, B., Parton, R. G., Simons, K.
core +4 more sources
Influence of epigallocatechin-3-gallate on okadaic acid-induced cell death [PDF]
, 2015 Okadaična kiselina je selektivni inhibitor serin/treonin fosfataza (PP1 i PP2A) koje kataliziraju defosforilaciju tau proteina i pojačava ekspresiju gena cdk5 i p25. Cdk5 inhibira fosfataze i time inducira hiperfosforilaciju tau proteina.
Kopčok, Vedrana
core
Activation of AtMPK9 through autophosphorylation that makes it independent of the canonical MAPK cascades. [PDF]
, 2015 Mitogen activated protein kinases (MAPKs) are part of conserved signal transduction modules in eukaryotes that are typically organised into three-tiered kinase cascades.
Bogre L +7 more
core +1 more source
Heat shock-induced phosphorylation of TAR DNA-binding protein 43 (TDP-43) by MAPK/ERK kinase regulates TDP-43 function [PDF]
, 2017 TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression through RNA processing, in particular, regulation of splicing.
Ayala, Yuna M +8 more
core +2 more sources
GABA(A) receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein [PDF]
, 2004 GABA(A) receptors are critical in controlling neuronal activity. Here, we examined the role for phospholipase C-related inactive protein type 1 (PRIP-1), which binds and inactivates protein phosphatase 1alpha (PP1alpha) in facilitating GABA(A) receptor ...
Akaike, N +10 more
core
Frontiers in Aging NeuroscienceIntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by decreased memory and cognitive impairment. Abnormal tau hyperphosphorylation ultimately forms neurofibrillary tangles, which is one of the most important ...
Jiahui Li +6 more
doaj +1 more source
Current situation on analysis of marine toxins
Reviews in Analytical Chemistry, 2013 Marine toxins are a food safety concern worldwide. This review discusses current analytical methods for those toxins that are legally regulated in Europe, namely domoic acid, saxitoxin, okadaic acid, yessotoxin, pectenotoxin and azaspiracids, and all ...
Botana Ana M. +4 more
doaj +1 more source