Results 101 to 110 of about 3,497 (175)

A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling

Frontiers in Aging Neuroscience
IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by decreased memory and cognitive impairment. Abnormal tau hyperphosphorylation ultimately forms neurofibrillary tangles, which is one of the most important ...
Jiahui Li, Jiahui Li, Yuan Xu, Yuan Xu, Gianfranco Balboni, Ying Xia, Ying Xia   +6 more
doaj   +1 more source

Current situation on analysis of marine toxins

Reviews in Analytical Chemistry, 2013
Marine toxins are a food safety concern worldwide. This review discusses current analytical methods for those toxins that are legally regulated in Europe, namely domoic acid, saxitoxin, okadaic acid, yessotoxin, pectenotoxin and azaspiracids, and all ...
Botana Ana M., Otero Paz, Rodríguez Paula, Alfonso Amparo, Botana Luis M.   +4 more
doaj   +1 more source

Generation of Internal-Image Functional Aptamers of Okadaic Acid via Magnetic-Bead SELEX

Marine Drugs, 2015
Okadaic acid (OA) is produced by Dinophysis and Prorocentrum dinoflagellates and primarily accumulates in bivalves, and this toxin has harmful effects on consumers and operators. In this work, we first report the use of aptamers as novel non-toxic probes
Chao Lin, Zeng-Shan Liu, Dong-Xu Wang, Lin Li, Pan Hu, Sheng Gong, Yan-Song Li, Cheng Cui, Zong-Cheng Wu, Yang Gao, Yu Zhou, Hong-Lin Ren, Shi-Ying Lu   +12 more
doaj   +1 more source

Isolation and identification of a cis-C₈-diol-ester of okadaic acid from Dinophysis acuta in New Zealand

, 2006
A cis-isomer of a C8-diol ester of okadaic acid (1) was isolated during large-scale purification of pectenotoxins (PTXs) from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand.
Lincoln MacKenzie, A., Hawkes, Allan D., Jensen, Dwayne J., Rise, Frode, Larsen, Kristofer, Wilkins, Alistair L., Petersen, Dirk, Beuzenberg, Veronica, Miles, Christopher O., Cooney, Janine M.   +9 more
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The effects of okadaic acid on Enchytraeus crypticus (Annelida: Oligochaeta) [PDF]

Invertebrate Survival Journal, 2006
We describe the morpho-functional effects of different concentrations of okadaic acid (OA) on specimens of Enchytraeus crypticus. The results demonstrate that this experimental model is very sensitive to the treatment and presents time- and dose-related ...
A Franchini, M Marchetti
doaj   +1 more source

Isolation and Characterization of Okadaic Acid Binding Proteins from the Marine Sponge Halichondria okadai^†

, 2016
Okadaic acid, first isolated from the marine sponge Halichondria okadai, is a potent inhibitor of protein phosphatases 1 and 2A (PP1 and PP2A, respectively).
Naoyuki Sugiyama (231975), Keiichi Konoki (1343721), Kazuo Tachibana (1716997)   +2 more
core   +1 more source

Acute inhibition of insulin-stimulated glucose transport by the phosphatase inhibitor, okadaic acid

, 2008
Insulin is thought to exert its effects on cellular function through the phosphorylation or dephosphorylation of specific regulatory substrates. We have analyzed the effects of okadaic acid, a potent inhibitor of type 1 and 2A protein phosphatases, on ...
Pasceri, Marguerite, Corvera, Silvia, Jaspers, Steven R.   +2 more
core  

Okadaic acid stimulates carnitine palmitoyltransferase I activity and palmitate oxidation in isolated rat hepatocytes

, 1991
Okadaic acid increased in parallel with carnitine palmitoyltransferase I activity and the rate of palmitate oxidation in isolated rat hepatocytes. Nevertheless, okadaic acid had no significant effect on the rate of octanoate oxidation. Maximal effects of
Castro, José, Guzmán, Manuel, Manuel Guzmán, José Castro   +3 more
core   +1 more source

An Efficient Total Synthesis of Okadaic Acid

, 2016
An Efficient Total Synthesis of Okadaic ...
Rebecca A. Urbanek (2004700), Craig J. Forsyth (1661140), Steven F. Sabes (3001659)   +2 more
core   +2 more sources

Kolaviron neuroprotective effect against okadaic acid-provoked cognitive impairment

Heliyon
Alzheimer's disease (AD) is acknowledged as the main causative factor of dementia that affects millions of people around the world and is increasing at increasing pace.
Morteza Nazari-Serenjeh, Tourandokht Baluchnejadmojarad, Masoud Hatami-Morassa, Javad Fahanik-Babaei, Soraya Mehrabi, Mahsa Tashakori-Miyanroudi, Samira Ramazi, Seyed-Mahdi Mohamadi-Zarch, Davood Nourabadi, Mehrdad Roghani   +9 more
doaj   +1 more source