Results 81 to 90 of about 2,519,072 (211)
In January 2010, the toxin-producing dinoflagellates Dinophysis acuminata and D. caudata (103 cells·l-1) were detected in Mar Azul during routine plankton monitoring in Buenos Aires Province coastal waters, Argentina.
Eugenia A. Sar +6 more
doaj +1 more source
Harmful algal blooms expose humans and animals to microcystins (MCs) through contaminated drinking water. While hepatotoxicity following acute exposure to MCs is well documented, neurotoxicity after sub-lethal exposure is poorly understood. We developed
Caroline E. Moore +2 more
doaj +1 more source
Effect of okadaic acid on histamine release from rat peritoneal mast cells activated by anti-IgE
The effect of okadaic acid, a potent inhibitor of protein phosphatase 1 and 2A, on histamine release from mast cells has been investigated. Okadaic acid strongly and dose-dependently inhibited histamine release from mast cells induced by anti-IgE.
Koichi Endo, Masao Takei, Hideki Mitsui
core +1 more source
ERETIC2 (Electronic Reference To access In vivo Concentrations 2) based on PULCON (Pulse Length–based Concentration determination) methodology is a quantitative NMR (qNMR) using an external standard.
Ryuichi Watanabe +7 more
doaj +1 more source
FIR irradiation enhances the physical association between Akt and PP2Ac in VSMCs, independent of the hyperthermal effect of FIR rays. The increased binding between Akt and PP2Ac induced by FIR irradiation facilitates the dephosphorylation of Akt at Ser473.
Na‐Young Lee +5 more
wiley +1 more source
Okadaic acid, which is known to be a cause of the diarrhetic shellfish poisoning, was tested for its effect on the morphology of primary cultures established from two bivalve species, Mytilus galloprovincialis and Crassostrea gigas.
Ogata, Hiroshi +9 more
core
Acute inhibition of insulin-stimulated glucose transport by the phosphatase inhibitor, okadaic acid [PDF]
Insulin is thought to exert its effects on cellular function through the phosphorylation or dephosphorylation of specific regulatory substrates. We have analyzed the effects of okadaic acid, a potent inhibitor of type 1 and 2A protein phosphatases, on ...
Pasceri, Marguerite +2 more
core
19-epi-Okadaic Acid, a Novel Protein Phosphatase Inhibitor with Enhanced Selectivity
A new protein phosphatase inhibitor, 19-epi-okadaic acid, was isolated from the marine dinoflagellate Prorocentrum belizeanum. Its structure and conformation in solution has been determined, and important differences were found when compared with the ...
Hernández Daranas, Antonio +3 more
core +1 more source
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins +9 more
wiley +1 more source
19-epi-Okadaic Acid, a Novel Protein Phosphatase Inhibitor with Enhanced Selectivity
A new protein phosphatase inhibitor, 19-epi-okadaic acid, was isolated from the marine dinoflagellate Prorocentrum belizeanum. Its structure and conformation in solution has been determined, and important differences were found when compared with the ...
Antonio Hernández Daranas (2473177) +3 more
core +1 more source

