Results 81 to 90 of about 2,519,072 (211)

First report of diarrheic shellfish toxins in mollusks from Buenos Aires Province (Argentina) associated with Dinophysis spp.: evidence of okadaic acid, dinophysistoxin-1 and their Acyl-derivatives

open access: yesBoletín de la Sociedad Argentina de Botánica
 In January 2010, the toxin-producing dinoflagellates Dinophysis acuminata and D. caudata (103 cells·l-1) were detected in Mar Azul during routine plankton monitoring in Buenos Aires Province  coastal waters, Argentina.
Eugenia A. Sar   +6 more
doaj   +1 more source

Microcystins Alter Chemotactic Behavior in Caenorhabditis elegans by Selectively Targeting the AWA Sensory Neuron

open access: yesToxins, 2014
Harmful algal blooms expose humans and animals to microcystins (MCs) through contaminated drinking water. While hepatotoxicity following acute exposure to MCs is well documented, neurotoxicity after sub-lethal exposure is poorly understood. We developed
Caroline E. Moore   +2 more
doaj   +1 more source

Effect of okadaic acid on histamine release from rat peritoneal mast cells activated by anti-IgE

open access: yes, 1993
The effect of okadaic acid, a potent inhibitor of protein phosphatase 1 and 2A, on histamine release from mast cells has been investigated. Okadaic acid strongly and dose-dependently inhibited histamine release from mast cells induced by anti-IgE.
Koichi Endo, Masao Takei, Hideki Mitsui
core   +1 more source

Quantitative Nuclear Magnetic Resonance Spectroscopy Based on PULCON Methodology: Application to Quantification of Invaluable Marine Toxin, Okadaic Acid

open access: yesToxins, 2016
ERETIC2 (Electronic Reference To access In vivo Concentrations 2) based on PULCON (Pulse Length–based Concentration determination) methodology is a quantitative NMR (qNMR) using an external standard.
Ryuichi Watanabe   +7 more
doaj   +1 more source

Far‐infrared irradiation attenuates platelet‐derived growth factor‐stimulated vascular smooth muscle cell migration through protein phosphatase 2A‐mediated Akt inhibition

open access: yesPhotochemistry and Photobiology, Volume 102, Issue 4, Page 996-1009, July/August 2026.
FIR irradiation enhances the physical association between Akt and PP2Ac in VSMCs, independent of the hyperthermal effect of FIR rays. The increased binding between Akt and PP2Ac induced by FIR irradiation facilitates the dephosphorylation of Akt at Ser473.
Na‐Young Lee   +5 more
wiley   +1 more source

The Effect of Okadaic Acid on Cultured Tissues of Bivalves, Mytilus galloprovincialis and Crassostrea gigas

open access: yes, 1994
Okadaic acid, which is known to be a cause of the diarrhetic shellfish poisoning, was tested for its effect on the morphology of primary cultures established from two bivalve species, Mytilus galloprovincialis and Crassostrea gigas.
Ogata, Hiroshi   +9 more
core  

Acute inhibition of insulin-stimulated glucose transport by the phosphatase inhibitor, okadaic acid [PDF]

open access: yes, 2008
Insulin is thought to exert its effects on cellular function through the phosphorylation or dephosphorylation of specific regulatory substrates. We have analyzed the effects of okadaic acid, a potent inhibitor of type 1 and 2A protein phosphatases, on ...
Pasceri, Marguerite   +2 more
core  

19-epi-Okadaic Acid, a Novel Protein Phosphatase Inhibitor with Enhanced Selectivity

open access: yes, 2007
A new protein phosphatase inhibitor, 19-epi-okadaic acid, was isolated from the marine dinoflagellate Prorocentrum belizeanum. Its structure and conformation in solution has been determined, and important differences were found when compared with the ...
Hernández Daranas, Antonio   +3 more
core   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

open access: yesAdvanced Functional Materials, Volume 36, Issue 52, 29 June 2026.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins   +9 more
wiley   +1 more source

19-epi-Okadaic Acid, a Novel Protein Phosphatase Inhibitor with Enhanced Selectivity

open access: yes, 2016
A new protein phosphatase inhibitor, 19-epi-okadaic acid, was isolated from the marine dinoflagellate Prorocentrum belizeanum. Its structure and conformation in solution has been determined, and important differences were found when compared with the ...
Antonio Hernández Daranas (2473177)   +3 more
core   +1 more source

Home - About - Disclaimer - Privacy