Results 61 to 70 of about 3,497 (175)
Journal of Neuroinflammation, 2021 Background Inflammation undermines multiple forms of neuroplasticity. Although inflammation and its influence on plasticity in multiple neural systems has been extensively studied, its effects on plasticity of neural networks controlling vital life ...
Arash Tadjalli +3 more
doaj +1 more source
Aging Cell, Volume 25, Issue 4, April 2026.Middle‐aged/older (MA/O) men with low testosterone have greater age‐related vascular endothelial dysfunction than MA/O with normal testosterone. This study highlights the potential role of mitochondrial dysfunction and reduced sirtuin 3, a key modulator of mitochondrial function and oxidative stress, in accelerated vascular aging in MA/O men with low ...
Branden L. Nguyen +14 more
wiley +1 more source
Experimental Basis for the High Oral Toxicity of Dinophysistoxin 1: A Comparative Study of DSP
Toxins, 2014 Okadaic acid (OA) and its analogues, dinophysistoxin 1 (DTX1) and dinophysistoxin 2 (DTX2), are lipophilic and heat-stable marine toxins produced by dinoflagellates, which can accumulate in filter-feeding bivalves.
Diego A. Fernández +5 more
doaj +1 more source
E3 ligase Praja1 mediates ubiquitination and degradation of microtubule‐associated protein tau
The FEBS Journal, Volume 293, Issue 8, Page 2212-2224, April 2026.The Praja family of RING‐H2 type E3 ligases is composed of E3 ubiquitin–protein ligases Praja1 and Praja2, which promote the degradation of substrates through the ubiquitin–proteasome system. We show that Praja1, but not its paralogue Praja2, recognizes and ubiquitinates tau protein for proteasomal degradation.
Shiho Aoki +8 more
wiley +1 more source
Specific binding of okadaic acid, a new tumor promoter in mouse skin
, 1989 The tumor promoter okadaic acid binds specifically to a particulate as well as a cytosolic fraction of various mouse tissues, e.g., skin, brain, lung and colon.
Fujiki, Hirota +11 more
core +1 more source
Cell Proliferation, Volume 59, Issue 3, March 2026.Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao +7 more
wiley +1 more source
Permeability characteristics of erythrocyte membrane to okadaic acid and calyculin A
, 1996 The rates of transport of the protein phosphatase inhibitors okadaic acid and calyculin A through rabbit erythrocyte membranes have been estimated by measuring protein phosphatase type 2A (PP2A) activity in lysates.
M. L. Jennings, A. N. Namboodiripad
core +1 more source
Marine Drugs, 2008 Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp.
José J. Fernández +5 more
doaj
Marine Drugs, 2015 Protein phosphatase 2A (PP2A) is a tumor suppressor complex that has recently been reported as a novel and highly relevant molecular target in prostate cancer (PCa). However, its potential therapeutic value remains to be fully clarified.
Ion Cristóbal +8 more
doaj +1 more source
Advanced Biology, Volume 10, Issue 2, February 2026.This study employs a compartmentalized neurofluidic platform to map extracellular vesicle (EV) secretion dynamics with the aim of increasing the spatial resolution at sub‐neuronal locations. It examines how growth conditions, exogenous forces, and Okadaic acid treatment affect primary neurons' EV release.
Zeynep Malkoc +4 more
wiley +1 more source