Results 61 to 70 of about 2,695,498 (213)
Experimental Physiology, Volume 111, Issue 10, Page 4565-4577, 1 October 2026.Abstract This study investigated Prangos ferulacea (PF)‐induced hepatotoxicity, its potential association with endoplasmic reticulum (ER) stress and proinflammatory cytokines, and the effect of the cannabinoid type 2 receptor agonist JWH‐133. Rats (n = 37) were divided into four groups: control–sham group (CSG, n = 9), PF extract group (PG, n = 9), PF ...
Mesut Çelik +7 more
wiley +1 more source
Minisatellite Instability Induced by Okadaic Acid.
THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN, 1997 Okadaic acid (OA) is an inhibitor of serine/threonine protein phosphatase (PP) and a tumor promoter in mouse skin carcinogenesis. According to Carcinogenesis Division, National Cancer Center Research Institute, OA induces various genetic alterations, such as loss of exogenous genes, sister chromatid exchanges and diphtheria toxin resistant mutants ...
openaire +3 more sources
FEBS Open Bio, Volume 16, Issue 9, Page 1786-1800, September 2026.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
, 1992 Okadaic acid completely inhibits phosphatase 2A at nanomolar concentrations, while complete inhibition of type 1 phosphatases occurs at 1 microM. Phosphatase 2B is significantly inhibited only at concentrations > 1 microM.
A. C. Wagner +3 more
core +1 more source
Detection of diarrheal shellfish toxins
Reviews in Analytical Chemistry, 2022 Seafood poisoning outbreaks are often caused by biotoxins generated by harmful algal blooms. Shellfish toxins, mainly derived from phytoplankton, cause diarrhea and poisoning in humans who consume contaminated seafood. Many studies suggest that diarrheal
Xu Rui +3 more
doaj +1 more source
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract Early disruption of gamma oscillations is increasingly recognized as a contributor to neurodegeneration and cognitive decline in Alzheimer's disease (AD), positioning 40‐Hz stimulation as a promising neuromodulatory strategy. However, its neurophysiological and cognitive effects remain highly variable across studies, underscoring the need for ...
Lin Qi +7 more
wiley +1 more source
, 2016 Okadaic acid, first isolated from the marine sponge Halichondria okadai, is a potent inhibitor of protein phosphatases 1 and 2A (PP1 and PP2A, respectively).
Naoyuki Sugiyama (231975) +2 more
core +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.Polystyrene nanoplastic particles (NPPs) interact with serum proteins, establishing nano‐bio interactions and triggering ROS‐mediated macrophage toxicity in THP‐1 cells, characterized by oxidative stress, mitochondrial dysfunction, apoptosis and stress‐signaling.
Balamurali Mahalakshmi +3 more
wiley +1 more source
Use of Okadaic Acid to Identify Relevant Phosphoepitopes in Pathology: A Focus on Neurodegeneration
Marine Drugs, 2013 Protein phosphorylation is involved in the regulation of a wide variety of physiological processes and is the result of a balance between protein kinase and phosphatase activities. Biologically active marine derived compounds have been shown to represent
Jesús Avila +2 more
doaj +1 more source
A Hierarchical Framework for In Vitro Models of Alzheimer's Disease
WIREs Mechanisms of Disease, Volume 18, Issue 5, September/October 2026.There is no “best” in vitro model of Alzheimer's disease. Instead, different experimental platforms address different biological questions, and their combined use may improve mechanistic understanding and translational success. ABSTRACT Alzheimer's disease (AD) remains a major global health challenge, with a high rate of clinical trial failures often ...
Florencia B. Balverde‐Caballero +2 more
wiley +1 more source