Results 61 to 70 of about 2,519,072 (211)
Okadaic acid, a phosphatase inhibitor, decreases macrophage motility
, 1991 Cellular locomotion results from a series of spatially and temporally integrated reactions. The coordinated regulation of these reactions requires sensitive intracellular signaling mechanisms.
A. Takai +3 more
core +1 more source
Minisatellite Instability Induced by Okadaic Acid.
THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN, 1997 Okadaic acid (OA) is an inhibitor of serine/threonine protein phosphatase (PP) and a tumor promoter in mouse skin carcinogenesis. According to Carcinogenesis Division, National Cancer Center Research Institute, OA induces various genetic alterations, such as loss of exogenous genes, sister chromatid exchanges and diphtheria toxin resistant mutants ...
openaire +3 more sources
Porous Organic Polymers: From Molecular Design to Scalable Technologies
Small, Volume 22, Issue 46, 18 August 2026.This review introduces porous organic polymers (POPs) for a wide range of applications, including energy storage, gas adsorption, catalysts, adsorbents, biomedical applications, sensors, and other exciting fields, and critically analyzes the synthesis and modification, and how structural topology influences the composites' architecture of POPs, along ...
Hossein Mashhadimoslem +12 more
wiley +1 more source
Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response [PDF]
, 2004 Microcystins, potent heptapeptide hepatotoxins produced by certain bloom-forming cyanobacteria, are strong protein phosphatase inhibitors. They covalently bind the serine/threonine protein phosphatases 1 and 2A (PP1 and PP2A), thereby influencing ...
Michelle M Gehringer +1 more
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Detection of diarrheal shellfish toxins
Reviews in Analytical Chemistry, 2022 Seafood poisoning outbreaks are often caused by biotoxins generated by harmful algal blooms. Shellfish toxins, mainly derived from phytoplankton, cause diarrhea and poisoning in humans who consume contaminated seafood. Many studies suggest that diarrheal
Xu Rui +3 more
doaj +1 more source
The Journal of Physiology, Volume 604, Issue 16, Page 6752-6770, 15 August 2026.Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi +11 more
wiley +1 more source
, 2014 Recently, there has been increasing interest in certain low dalton marine toxins, as they have been implicated in seafood poisonings. The toxins include ciguatoxin (CTX), which is implicated in ciguatera fish poisoning, and okadaic acid (OA), which is ...
Hong, Terri-lynn
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Use of Okadaic Acid to Identify Relevant Phosphoepitopes in Pathology: A Focus on Neurodegeneration
Marine Drugs, 2013 Protein phosphorylation is involved in the regulation of a wide variety of physiological processes and is the result of a balance between protein kinase and phosphatase activities. Biologically active marine derived compounds have been shown to represent
Jesús Avila +2 more
doaj +1 more source
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract INTRODUCTION Pathological tau aggregates are key therapeutic targets in Alzheimer's disease (AD), but current approaches face limitations including poor intracellular penetration, lack of selectivity for aggregated over physiological tau, or reliance on invasive administration.
Nicolas Preitner +19 more
wiley +1 more source
Okadaic acid inhibits amylase exocytosis from parotid acini stimulated by cyclic AMP [PDF]
, 1991 To evaluate the role of protein phosphorylation in amylase exocytosis, we studied the effects of okadaic acid, a potent inhibitor of protein phosphatase types I and 2A, on amylase release and protein phosphorylation in rat parotid acini. Although okadaic
Taishin Takuma +3 more
core +1 more source