Results 61 to 70 of about 22,039 (219)
PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38. [PDF]
, 2015 PPM1D phosphatase, also called wild-type p53-induced phosphatase 1, promotes tumor development by inactivating the p53 tumor suppressor pathway.
Chen, X, Xu, E, Zhang, J, Zhang, M
core +2 more sources
Minisatellite Instability Induced by Okadaic Acid.
THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN, 1997 Okadaic acid (OA) is an inhibitor of serine/threonine protein phosphatase (PP) and a tumor promoter in mouse skin carcinogenesis. According to Carcinogenesis Division, National Cancer Center Research Institute, OA induces various genetic alterations, such as loss of exogenous genes, sister chromatid exchanges and diphtheria toxin resistant mutants ...
openaire +3 more sources
Aging Cell, Volume 25, Issue 4, April 2026.Middle‐aged/older (MA/O) men with low testosterone have greater age‐related vascular endothelial dysfunction than MA/O with normal testosterone. This study highlights the potential role of mitochondrial dysfunction and reduced sirtuin 3, a key modulator of mitochondrial function and oxidative stress, in accelerated vascular aging in MA/O men with low ...
Branden L. Nguyen +14 more
wiley +1 more source
Detection of diarrheal shellfish toxins
Reviews in Analytical Chemistry, 2022 Seafood poisoning outbreaks are often caused by biotoxins generated by harmful algal blooms. Shellfish toxins, mainly derived from phytoplankton, cause diarrhea and poisoning in humans who consume contaminated seafood. Many studies suggest that diarrheal
Xu Rui +3 more
doaj +1 more source
Sensitive time-resolved fluoroimmunoassay for the quantitative detection of okadaic acid
Frontiers in Marine Science, 2022 Okadaic acid (OA) is a biotoxin from marine microalgae and widely present in shellfish, which severely affects the seafood safety. Therefore, it is essential to establish a highly sensitive OA analysis and detection method.
Yuan Qin +9 more
doaj +1 more source
Insulin Action on Polyunsaturated Phosphatidic Acid Formation in Rat Brain: An “In Vitro” Model with Synaptic Endings from Cerebral Cortex and Hippocampus [PDF]
, 2009 The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported.
Giusto, Norma Maria +2 more
core +1 more source
E3 ligase Praja1 mediates ubiquitination and degradation of microtubule‐associated protein tau
The FEBS Journal, Volume 293, Issue 8, Page 2212-2224, April 2026.The Praja family of RING‐H2 type E3 ligases is composed of E3 ubiquitin–protein ligases Praja1 and Praja2, which promote the degradation of substrates through the ubiquitin–proteasome system. We show that Praja1, but not its paralogue Praja2, recognizes and ubiquitinates tau protein for proteasomal degradation.
Shiho Aoki +8 more
wiley +1 more source
Use of Okadaic Acid to Identify Relevant Phosphoepitopes in Pathology: A Focus on Neurodegeneration
Marine Drugs, 2013 Protein phosphorylation is involved in the regulation of a wide variety of physiological processes and is the result of a balance between protein kinase and phosphatase activities. Biologically active marine derived compounds have been shown to represent
Jesús Avila +2 more
doaj +1 more source
β2-Adaptin is constitutively de-phosphorylated by serine/threonine protein phosphatase PP2A and phosphorylated by a staurosporine-sensitive kinase [PDF]
, 2000 Clathrin-mediated endocytosis includes cycles of assembly and disassembly of the clathrin-coated vesicle constituents. How these cycles are regulated is still not fully known but previous studies have indicated that phosphorylation of coat subunits may ...
Lauritsen, Jens Peter H +5 more
core +1 more source
Cell Proliferation, Volume 59, Issue 3, March 2026.Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao +7 more
wiley +1 more source