Results 61 to 70 of about 14,228 (214)
Studies on the release of okadaic acid in Prorocentrum lima and the methodological optimization of okadaic acid purification [PDF]
, 2007 本研究探討黑海綿酸的提純最適化，在研究初期發現藻細胞在培養至穩定期後，釋放黑海綿酸到培養液中的濃度大量提高，不利於從藻細胞內提純黑海綿酸，此時針對培養液中黑海綿酸的提純，較從藻細胞後內提純更簡單，因此本研究以合成吸附樹脂SP825吸附培養液中的黑海綿酸後，再行脫附提純。SP825對黑海綿酸吸附實驗中，發現SP825吸附承載量至少為4.736 mg/g，而SP825對黑海綿酸的脫附率可達96.9 %，整個操作不僅能完全吸附培養基中的黑海綿酸，並可利用甲醇來達到脫附毒素的目的，增加量化生產時濃縮操作的方便性，
Wu, Jain-Shin, 吳建欣
core
Glia, Volume 74, Issue 7, July 2026.SNPs in SH3RF3 decrease the age of onset of Alzheimer's disease (AD). Reduced SH3RF3 blunts human microglial JNK and NFkB signaling and downstream inflammatory cytokine production, which may partially explain how SH3RF3 SNPs protect against AD. ABSTRACT Understanding how high‐risk individuals are protected from Alzheimer's disease (AD) may illuminate ...
Ronak Patel +13 more
wiley +1 more source
Cross-Reactivity of Ciguatoxin, Okadaic Acid, and Okadaic Acid Segments C with Monoclonal Antibodies to Ciguatoxin and Okadaic Acid [PDF]
, 2014 Recently, there has been increasing interest in certain low dalton marine toxins, as they have been implicated in seafood poisonings. The toxins include ciguatoxin (CTX), which is implicated in ciguatera fish poisoning, and okadaic acid (OA), which is ...
Hong, Terri-lynn
core
Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Formal Total Synthesis of Okadaic Acid via Regiocontrolled Gold(I)-Catalyzed Spiroketalizations [PDF]
, 2016 Both C19 and C34 spiroketal domains of okadaic acid were assembled using gold(I) chloride catalyzed spiroketalizations, and the two resulting fragments were coupled to give the C15−C38 fragment of okadaic acid, a known intermediate for the total ...
Chao Fang (456315) +2 more
core +1 more source
APP/Aβ Signaling Orchestrates Reactive Astrocyte Networks in Alzheimer's Disease
Journal of Neurochemistry, Volume 170, Issue 7, July 2026.Stress increases astrocyte APP production, generating amyloid‐β (Aβ). Aβ then diffuses to neighboring astrocytes, stimulating further APP and Aβ production and creating a self‐reinforcing cycle. Over time, impaired Aβ clearance leads to its accumulation, chronic inflammation, and contributes to sporadic Alzheimer's disease. ABSTRACT Alzheimer's disease
Gretsen Velezmoro Jauregui +16 more
wiley +1 more source
Effect of okadaic acid on human basophil secretion
Biochemical Pharmacology, 1993 We examined the effects of a phosphatase inhibitor, okadaic acid, on mediator secretion from human basophils. These cells are known to respond to a number of stimuli that appear to utilize distinct biochemical pathways converging on mediator release.
L M, Botana, D W, MacGlashan
openaire +2 more sources
Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response [PDF]
, 2004 Microcystins, potent heptapeptide hepatotoxins produced by certain bloom-forming cyanobacteria, are strong protein phosphatase inhibitors. They covalently bind the serine/threonine protein phosphatases 1 and 2A (PP1 and PP2A), thereby influencing ...
Michelle M Gehringer +1 more
core +1 more source
Photochemistry and Photobiology, Volume 102, Issue 4, Page 996-1009, July/August 2026.FIR irradiation enhances the physical association between Akt and PP2Ac in VSMCs, independent of the hyperthermal effect of FIR rays. The increased binding between Akt and PP2Ac induced by FIR irradiation facilitates the dephosphorylation of Akt at Ser473.
Na‐Young Lee +5 more
wiley +1 more source
Promotion of BALB/3T3 Cell Transformation by the Okadaic Acid Class of Tumor Promoters, Okadaic Acid and Dinophysistoxin‐1 [PDF]
Japanese Journal of Cancer Research, 1991 Okadaic acid and dinophysistoxin‐1 are non‐12‐O‐tetradecanoylphorbol‐13‐acetate (non‐TPA)‐type tumor promoters, which enhance chemically induced tumorigenesis on mouse skin through a different mechanism from that of TPA. In the present study, we examined the promoting effects of these okadaic acid class tumor promoters on a two‐stage transformation ...
Sakai, Ayako, Fujiki, Hirota
openaire +2 more sources