Results 51 to 60 of about 3,497 (175)

Estudo da frequência de hemócitos micronucleados, induzidos pelo ácido ocadáico, em mexilhões Perna perna (Mollusca : Bivalvia) / [PDF]

, 2000
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.Algumas toxinas presentes naturalmente no ambiente marinho são capazes de induzir mutagenicidade e/ou carcinogenicidade.
Silva, Cátia Regina
core  

Okadaic acid, a phosphatase inhibitor, decreases macrophage motility

, 1991
Cellular locomotion results from a series of spatially and temporally integrated reactions. The coordinated regulation of these reactions requires sensitive intracellular signaling mechanisms.
A. Takai, P. de Lanerolle, J. C. Ruegg, A. K. Wilson   +3 more
core   +1 more source

Effect of okadaic acid on human basophil secretion

Biochemical Pharmacology, 1993
We examined the effects of a phosphatase inhibitor, okadaic acid, on mediator secretion from human basophils. These cells are known to respond to a number of stimuli that appear to utilize distinct biochemical pathways converging on mediator release.
L M, Botana, D W, MacGlashan
openaire   +2 more sources

Effects of okadaic acid indicate a role for dephosphorylation in pancreatic stimulus-secretion coupling

, 1992
Okadaic acid completely inhibits phosphatase 2A at nanomolar concentrations, while complete inhibition of type 1 phosphatases occurs at 1 microM. Phosphatase 2B is significantly inhibited only at concentrations > 1 microM.
A. C. Wagner, J. A. Williams, M. J. Wishart, D. I. Yule   +3 more
core   +1 more source

Promotion of BALB/3T3 Cell Transformation by the Okadaic Acid Class of Tumor Promoters, Okadaic Acid and Dinophysistoxin‐1 [PDF]

Japanese Journal of Cancer Research, 1991
Okadaic acid and dinophysistoxin‐1 are non‐12‐O‐tetradecanoylphorbol‐13‐acetate (non‐TPA)‐type tumor promoters, which enhance chemically induced tumorigenesis on mouse skin through a different mechanism from that of TPA. In the present study, we examined the promoting effects of these okadaic acid class tumor promoters on a two‐stage transformation ...
Sakai, Ayako, Fujiki, Hirota
openaire   +2 more sources

Love wave biosensor for real-time detection of okadaic acid as DSP phycotoxin

, 2010
Love wave acoustic delay lines were used as sensors for okadaic acid immuno-detection through immobilized specific antibodies. Anti-okadaic acid antibodies were grafted onto the sensor surface.
C. Dejous, Moynet, D., Mossalayi, D., Fournel, F., M. Degueil, Degueil, Marie, L. Vellutini, Bennetau, B., Vellutini, Luc, Dejous, Corinne, Rebiere, D., D. Moynet, Mamani-Matsuda, M., Pillot, Jean-Paul, F. Fournel, M. Mamani-Matsuda, Dejous, C., Baco, E., Pillot, J.-P., Rebière, Dominique, D. Rebiere, Vellutini, L., E. Baco, J.-P. Pillot, Mossalayi, Djavad, D. Mossalayi, Moynet, Daniel, B. Bennetau, Bennetau, Bernard, Mamani-Matsuda, Maria, Fournel, Fabien, Baco, Etienne, Degueil, M.   +32 more
core   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

Use of Okadaic Acid to Identify Relevant Phosphoepitopes in Pathology: A Focus on Neurodegeneration

Marine Drugs, 2013
Protein phosphorylation is involved in the regulation of a wide variety of physiological processes and is the result of a balance between protein kinase and phosphatase activities. Biologically active marine derived compounds have been shown to represent
Jesús Avila, Miguel Medina, Nieves Villanueva   +2 more
doaj   +1 more source

Safety of oil from Schizochytrium sp. A2 for use in infant and follow‐on formula as a novel food pursuant to regulation (EU) 2015/2283

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of an oil derived from the microalga‐like organism Schizochytrium sp. A2 as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Thomas Frenzel, Margarita Aguilera‐Gómez, Francesca Marcon, Monika Neuhäuser‐Berthold, Irene Nuin Garciarena, Emanuela Turla, Areti Favata, Karen Ildico Hirsch‐Ernst   +22 more
wiley   +1 more source

Minisatellite Instability Induced by Okadaic Acid.

THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN, 1997
Okadaic acid (OA) is an inhibitor of serine/threonine protein phosphatase (PP) and a tumor promoter in mouse skin carcinogenesis. According to Carcinogenesis Division, National Cancer Center Research Institute, OA induces various genetic alterations, such as loss of exogenous genes, sister chromatid exchanges and diphtheria toxin resistant mutants ...
openaire   +3 more sources