Results 51 to 60 of about 2,519,072 (211)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, Volume 16, Issue 9, Page 1786-1800, September 2026.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Estudo da frequência de hemócitos micronucleados, induzidos pelo ácido ocadáico, em mexilhões Perna perna (Mollusca : Bivalvia) / [PDF]

, 2000
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.Algumas toxinas presentes naturalmente no ambiente marinho são capazes de induzir mutagenicidade e/ou carcinogenicidade.
Silva, Cátia Regina
core  

Evidence for physiological functions of protein phosphatases in the heart: evaluation with okadaic acid

, 1993
Okadaic acid exerts a positive inotropic effect in cardiac preparations. We studied whether the positive inotropic effect of okadaic acid in cardiac preparations could be due to phosphatase inhibition and whether this inhibition affects the ...
A. M. Watanabe, S. Herzig, R. C. Gupta, J. Neumann, W. Schmitz, P. Boknik, H. Scholz   +6 more
core   +1 more source

Self-Association of Okadaic Acid: Structural and Pharmacological Significance

Marine Drugs, 2013
Okadaic acid (OA) has been an invaluable pharmacological tool in the study of cellular signaling. The great affinity of this polyether for its targets together with its high specificity to inhibit certain protein phosphatases enables the differential ...
José J. Fernández, Antonio Hernández Daranas, Alberto Hernández Creus, Patricia G. Cruz, Manuel Norte   +4 more
doaj   +1 more source

Neurobiological mechanisms of 40‐Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract Early disruption of gamma oscillations is increasingly recognized as a contributor to neurodegeneration and cognitive decline in Alzheimer's disease (AD), positioning 40‐Hz stimulation as a promising neuromodulatory strategy. However, its neurophysiological and cognitive effects remain highly variable across studies, underscoring the need for ...
Lin Qi, Weiye Wang, Reema Abdullah, Yilei Zhao, Zhibin Wang, Yi Tang, Benyan Luo, Guoping Peng   +7 more
wiley   +1 more source

Nanoplastic Particle Exposure Induces Toxicity and Amplifies Cellular Stress in THP‐1 Macrophages: Insights on Molecular Pathways and Circulating Proteome Interaction

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Polystyrene nanoplastic particles (NPPs) interact with serum proteins, establishing nano‐bio interactions and triggering ROS‐mediated macrophage toxicity in THP‐1 cells, characterized by oxidative stress, mitochondrial dysfunction, apoptosis and stress‐signaling.
Balamurali Mahalakshmi, Gobichettipalayam Balasubramaniam Maadurshni, Thittumpuram Manikandan Anjana, Jeganathan Manivannan   +3 more
wiley   +1 more source

Effect of okadaic acid on human basophil secretion

Biochemical Pharmacology, 1993
We examined the effects of a phosphatase inhibitor, okadaic acid, on mediator secretion from human basophils. These cells are known to respond to a number of stimuli that appear to utilize distinct biochemical pathways converging on mediator release.
L M, Botana, D W, MacGlashan
openaire   +2 more sources

Structure‐Guided Optimization of a Molecular Glue Targeting the KBTBD4‐HDAC1/2 Complex

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Structure‐based optimization of the molecular glue degrader UM171 resulted in a near 20‐fold improvement of ternary complex stability but also revealed the challenges of glue discovery. Optimization of UM171, a molecular glue initiating the degradation of neosubstrate HDAC1/2–CoREST–LSD1 through a multiprotein complex formed with KBTBD4, was carried ...
Timea Balo, Zhuoyao Chen, Laurine Palluaud, Arpad Kiss, Tibor Novak, Andras Herner, Alex N. Bullock, Virginie Martiny, Andras Kotschy   +8 more
wiley   +1 more source

Effects of okadaic acid indicate a role for dephosphorylation in pancreatic stimulus-secretion coupling

, 1992
Okadaic acid completely inhibits phosphatase 2A at nanomolar concentrations, while complete inhibition of type 1 phosphatases occurs at 1 microM. Phosphatase 2B is significantly inhibited only at concentrations > 1 microM.
A. C. Wagner, J. A. Williams, M. J. Wishart, D. I. Yule   +3 more
core   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source