Results 51 to 60 of about 14,228 (214)

The Effect of Okadaic Acid on Cultured Tissues of Bivalves, Mytilus galloprovincialis and Crassostrea gigas [PDF]

, 1994
Okadaic acid, which is known to be a cause of the diarrhetic shellfish poisoning, was tested for its effect on the morphology of primary cultures established from two bivalve species, Mytilus galloprovincialis and Crassostrea gigas.
Ogata, Hiroshi, 青野, 英明, 2039, Aono, Hideaki, 80443357, 515, 尾形, 博, オガタ, ヒロシ, アオノ, ヒデアキ, 10371874   +9 more
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Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source

Okadaic acid disrupts Golgi structure and impairs enzyme synthesis and secretion in the rat pancreas [PDF]

, 1996
Okadaic acid, a serine/threonine phosphatase inhibitor, has been shown to inhibit rat pancreatic enzyme secretion by interference with late processes in stimulus-secretion coupling.
B. Agricola, W. E. Schmidt, M. L. Kruse, I. H. Waschulewski, H. F. Kern   +4 more
core   +1 more source

Co-occurrence of marine and freshwater phycotoxins in oysters, and analysis of possible predictors for management

Toxicon: X, 2023
Oysters (Crassostrea virginica) were screened for 12 phycotoxins over two years in nearshore waters to collect baseline phycotoxin data and to determine prevalence of phycotoxin co-occurrence in the commercially and ecologically-relevant species.
Sarah K.D. Pease, Todd A. Egerton, Kimberly S. Reece, Marta P. Sanderson, Michelle D. Onofrio, Evan Yeargan, Adam Wood, Amanda Roach, I-Shuo Wade Huang, Gail P. Scott, Allen R. Place, Amy M. Hayes, Juliette L. Smith   +12 more
doaj   +1 more source

Elimination of tau tangles and soluble aggregates with the small molecule ACI‐16664 prevents neurodegeneration in vivo

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Pathological tau aggregates are key therapeutic targets in Alzheimer's disease (AD), but current approaches face limitations including poor intracellular penetration, lack of selectivity for aggregated over physiological tau, or reliance on invasive administration.
Nicolas Preitner, Véronique Dehlinger, Patrick Rodriguez, Kerstin Fabbri, Yvan Varisco, Matteo Pigni, Alessandra Lovison, Lucas Münzenmaier, Kasia Piorkowska, Aline Fuchs, Nadine Ait‐Bouziad, Nicolas Fournier, Sandra Jepaul, Jérôme Molette, Emanuele Gabellieri, Vincent Darmency, Sonia Poli, Andrea Pfeifer, Marie Kosco‐Vilbois, Francesca Capotosti   +19 more
wiley   +1 more source

Estudo da frequência de hemócitos micronucleados, induzidos pelo ácido ocadáico, em mexilhões Perna perna (Mollusca : Bivalvia) / [PDF]

, 2000
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.Algumas toxinas presentes naturalmente no ambiente marinho são capazes de induzir mutagenicidade e/ou carcinogenicidade.
Silva, Cátia Regina
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An idiotypic-anti-idiotypic competitive immunoassay for quantitation of okadaic acid [PDF]

, 1992
A competitive indirect enzyme-linked immunosorbent assay for the measurement of okadaic acid, a marine toxin, was developed. The assay uses a murine monoclonal anti-idiotypic antibody bearing an internal image of okadiac acid epitope to capture an anti ...
Quilliam, Michael A., William S. Shestowsky, Shestowsky, William S., Hanna M. Sikorska, Sikorska, Hanna M., Michael A. Quilliam   +5 more
core   +1 more source

A rapid competitive ELISA assay of Okadaic acid level based on epoxy-functionalized magnetic beads

Food and Agricultural Immunology, 2019
Using newly designed epoxy group activated carbon shell magnetic beads as a goat against mouse antibody (G-Mab) carrier, a competitive immunoassay was conducted on the surface of G-Mab-coated magnetic beads (G-Mab-MBs).
Linjiang Pang, Haoran Quan, Ying Sun, Pingya Wang, Daifu Ma, Pengqian Mu, Tingting Chai, Yiming Zhang, Bruce D. Hammock   +8 more
doaj   +1 more source

Self-Association of Okadaic Acid: Structural and Pharmacological Significance

Marine Drugs, 2013
Okadaic acid (OA) has been an invaluable pharmacological tool in the study of cellular signaling. The great affinity of this polyether for its targets together with its high specificity to inhibit certain protein phosphatases enables the differential ...
José J. Fernández, Antonio Hernández Daranas, Alberto Hernández Creus, Patricia G. Cruz, Manuel Norte   +4 more
doaj   +1 more source

PHLPP is neither a Phosphatase nor a Tumor Suppressor

BioEssays, Volume 48, Issue 7, July 2026.
PH domain leucine‐rich repeat protein phosphatases (PHLPP) have been described as Akt phosphatases and tumor suppressors for more than 20 years. Recent evidence, however, indicates that they are pseudophosphatases that lost catalytic activity more than 450 Mya. This article argues that new hypotheses are urgently needed to reorient the field.
Thomas A. Leonard
wiley   +1 more source