Results 71 to 80 of about 22,039 (219)
Journal of Neuroinflammation, 2021 Background Inflammation undermines multiple forms of neuroplasticity. Although inflammation and its influence on plasticity in multiple neural systems has been extensively studied, its effects on plasticity of neural networks controlling vital life ...
Arash Tadjalli +3 more
doaj +1 more source
Transformation of a marine toxic polyether, okadaic acid. [PDF]
Agricultural and Biological Chemistry, 1988 Natural okadaic acid 1 was transformed into the 7, 24, 27-tri-0-benzyl-l, 2-acetonide derivative (4) in a 66% overall yidd. The corresponding synthetic derivative (4) was identified with this authentic sample.
Yoshiyasu Ichikawa +2 more
openaire +2 more sources
Advanced Biology, Volume 10, Issue 2, February 2026.This study employs a compartmentalized neurofluidic platform to map extracellular vesicle (EV) secretion dynamics with the aim of increasing the spatial resolution at sub‐neuronal locations. It examines how growth conditions, exogenous forces, and Okadaic acid treatment affect primary neurons' EV release.
Zeynep Malkoc +4 more
wiley +1 more source
Experimental Basis for the High Oral Toxicity of Dinophysistoxin 1: A Comparative Study of DSP
Toxins, 2014 Okadaic acid (OA) and its analogues, dinophysistoxin 1 (DTX1) and dinophysistoxin 2 (DTX2), are lipophilic and heat-stable marine toxins produced by dinoflagellates, which can accumulate in filter-feeding bivalves.
Diego A. Fernández +5 more
doaj +1 more source
Phosphorylation of BK channels modulates the sensitivity to hydrogen sulfide (H2S) [PDF]
, 2014 Introduction: Gases, such as nitric oxide (NO), carbon monoxide (CO) or hydrogen sulfide (H2S), termed gasotransmitters, play an increasingly important role in understanding of how electrical signaling of cells is modulated.
Anton eHermann +5 more
core +2 more sources
British Journal of Haematology, Volume 208, Issue 2, Page 446-458, February 2026.This review highlights how studies on animal red cells have enriched our understanding of the behaviour of those from humans. A comparative perspective has enhanced our knowledge of human red cell pathophysiology Summary This review emphasises how studies on animal red cells have enriched our understanding of the behaviour of those from humans.
Kathleen M. Connolly +5 more
wiley +1 more source
Eukaryotic translation initiation machinery can operate in a prokaryotic-like mode without eIF2 [PDF]
, 2008 Unlike prokaryotes, a specialized eukaryotic initiation factor 2 (eIF2), in the form of the ternary complex eIF2*GTP*Met-tRNAiMet is utilized to deliver the initiator tRNA to the ribosome within all eukaryotic cells1.
Dmitri Andreev +3 more
core +1 more source
Advanced Science, Volume 13, Issue 6, 30 January 2026.Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun +9 more
wiley +1 more source
Marine Drugs, 2015 Protein phosphatase 2A (PP2A) is a tumor suppressor complex that has recently been reported as a novel and highly relevant molecular target in prostate cancer (PCa). However, its potential therapeutic value remains to be fully clarified.
Ion Cristóbal +8 more
doaj +1 more source
Phosphorylation of CREB affects its binding to high and low affinity sites [PDF]
, 1992 Cyclic AMP treatment of hepatoma cells leads to increased protein binding at the cyclic AMP response element (CRE) of the tyrosine aminotransferase (TAT) gene in vivo, as revealed by genomic footprinting, whereas no increase is observed at the CRE of the
Boshart, Michael +7 more
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