Results 71 to 80 of about 2,519,072 (211)

Experimental Basis for the High Oral Toxicity of Dinophysistoxin 1: A Comparative Study of DSP

Toxins, 2014
Okadaic acid (OA) and its analogues, dinophysistoxin 1 (DTX1) and dinophysistoxin 2 (DTX2), are lipophilic and heat-stable marine toxins produced by dinoflagellates, which can accumulate in filter-feeding bivalves.
Diego A. Fernández, M. Carmen Louzao, María Fraga, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana   +5 more
doaj   +1 more source

Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity

Journal of Neuroinflammation, 2021
Background Inflammation undermines multiple forms of neuroplasticity. Although inflammation and its influence on plasticity in multiple neural systems has been extensively studied, its effects on plasticity of neural networks controlling vital life ...
Arash Tadjalli, Yasin B. Seven, Raphael R. Perim, Gordon S. Mitchell   +3 more
doaj   +1 more source

PHLPP is neither a Phosphatase nor a Tumor Suppressor

BioEssays, Volume 48, Issue 7, July 2026.
PH domain leucine‐rich repeat protein phosphatases (PHLPP) have been described as Akt phosphatases and tumor suppressors for more than 20 years. Recent evidence, however, indicates that they are pseudophosphatases that lost catalytic activity more than 450 Mya. This article argues that new hypotheses are urgently needed to reorient the field.
Thomas A. Leonard
wiley   +1 more source

Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection

Marine Drugs, 2008
Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp.
José J. Fernández, Manuel Norte, José M. Franco, Patricia G. Cruz, Antonio H. Daranas, Beatriz Paz   +5 more
doaj  

Reduced SH3RF3 May Protect Against Alzheimer's Disease by Lowering Microglial Pro‐Inflammatory Responses via Modulation of JNK and NFkB Signaling

Glia, Volume 74, Issue 7, July 2026.
SNPs in SH3RF3 decrease the age of onset of Alzheimer's disease (AD). Reduced SH3RF3 blunts human microglial JNK and NFkB signaling and downstream inflammatory cytokine production, which may partially explain how SH3RF3 SNPs protect against AD. ABSTRACT Understanding how high‐risk individuals are protected from Alzheimer's disease (AD) may illuminate ...
Ronak Patel, Rong Cheng, Christopher L. Cardona, Ellen Angeles, Gunjandeep Singh, Sabrina Miller, Archana Ashok, Andrew F. Teich, Angel Piriz, Aleyda Maldonado, Ivonne Z. Jiménez‐Velázquez, Richard Mayeux, Joseph H. Lee, Andrew A. Sproul   +13 more
wiley   +1 more source

Effects of okadaic acid on the activities of two distinct phosphatidate phosphohydrolases in rat hepatocytes [PDF]

, 1992
Incubation of hepatocytes with okadaic acid displaced the N-ethylmaleimide-sensitive phosphatidate phosphohydrolase from the membrane fraction into the cytosol and partially prevented the oleate-induced movement of phosphohydrolase from cytosol to ...
Brindley, David N., Hatch, Grant M., Martin, Ashley, Gomez-Muñoz, Antonio, Vance, Dennis E., Zahirali Jamal, Antonio Gomez-Muñoz, Jamal, Zahirali, Grant M. Hatch, Dennis E. Vance, David N. Brindley, Ashley Martin   +11 more
core   +1 more source

Activation of the Tumor Suppressor PP2A Emerges as a Potential Therapeutic Strategy for Treating Prostate Cancer

Marine Drugs, 2015
Protein phosphatase 2A (PP2A) is a tumor suppressor complex that has recently been reported as a novel and highly relevant molecular target in prostate cancer (PCa). However, its potential therapeutic value remains to be fully clarified.
Ion Cristóbal, Paula González-Alonso, Lina Daoud, Esther Solano, Blanca Torrejón, Rebeca Manso, Juan Madoz-Gúrpide, Federico Rojo, Jesús García-Foncillas   +8 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Permeability characteristics of erythrocyte membrane to okadaic acid and calyculin A

, 1996
The rates of transport of the protein phosphatase inhibitors okadaic acid and calyculin A through rabbit erythrocyte membranes have been estimated by measuring protein phosphatase type 2A (PP2A) activity in lysates.
M. L. Jennings, A. N. Namboodiripad
core   +1 more source

APP/Aβ Signaling Orchestrates Reactive Astrocyte Networks in Alzheimer's Disease

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Stress increases astrocyte APP production, generating amyloid‐β (Aβ). Aβ then diffuses to neighboring astrocytes, stimulating further APP and Aβ production and creating a self‐reinforcing cycle. Over time, impaired Aβ clearance leads to its accumulation, chronic inflammation, and contributes to sporadic Alzheimer's disease. ABSTRACT Alzheimer's disease
Gretsen Velezmoro Jauregui, Sophie Coomes, Elizabeth Emmett, Alex Thatcher, Nicole Oyelakin, Maria Čarna, Jana Zelinkova, Jan Sebastian Novotny, Natalie Polakova, Tarun Kuruvilla, Robert Zorec, Alexei Verkhratsky, Vladimir Parpura, David Morgan, Kenneth L. Moya, Clara Limback‐Stokin, Gorazd Bernard Stokin   +16 more
wiley   +1 more source