Results 71 to 80 of about 3,497 (175)

19-epi-Okadaic Acid, a Novel Protein Phosphatase Inhibitor with Enhanced Selectivity

, 2007
A new protein phosphatase inhibitor, 19-epi-okadaic acid, was isolated from the marine dinoflagellate Prorocentrum belizeanum. Its structure and conformation in solution has been determined, and important differences were found when compared with the ...
Hernández Daranas, Antonio, Norte, Manuel, Fernández, José J., Cruz, Patricia G.   +3 more
core   +1 more source

Microcystins Alter Chemotactic Behavior in Caenorhabditis elegans by Selectively Targeting the AWA Sensory Neuron

Toxins, 2014
Harmful algal blooms expose humans and animals to microcystins (MCs) through contaminated drinking water. While hepatotoxicity following acute exposure to MCs is well documented, neurotoxicity after sub-lethal exposure is poorly understood. We developed
Caroline E. Moore, Pamela J. Lein, Birgit Puschner   +2 more
doaj   +1 more source

Across species: A comparative perspective on red cell homeostasis and its influence on our understanding of human physiology and disease

British Journal of Haematology, Volume 208, Issue 2, Page 446-458, February 2026.
This review highlights how studies on animal red cells have enriched our understanding of the behaviour of those from humans. A comparative perspective has enhanced our knowledge of human red cell pathophysiology Summary This review emphasises how studies on animal red cells have enriched our understanding of the behaviour of those from humans.
Kathleen M. Connolly, Pengyi Ding, Rasiqh Wadud, David C. Rees, John N. Brewin, John S. Gibson   +5 more
wiley   +1 more source

Self-Assembly of Okadaic Acid as a Pathway to the Cell

Organic Letters, 2007
The polyether toxin okadaic acid (OA) inhibits several protein serine/threonine phosphatases that play central roles in the regulation of many essential cellular processes. The use of scanning tunneling microscopy (STM) shows that dimerization of such toxins is crucial to understand the mechanism of toxin transport across model membranes.
Hernández Daranas, Antonio, Cruz, Patricia G., Hernández Creus, Alberto, Norte, Manuel, Fernández, José J.   +4 more
openaire   +3 more sources

Mass Spectral Characterisation of Three New Groups of Algal Toxins

, 2009
This thesis reports the mass spectral identification and characterisation of three new groups of algal compounds. A series of novel pectenotoxins (PTXs) were identified in retained sub-samples of Irish mussel extracts that had previously been utilised ...
Knudsen, Brent Kevin
core  

Effect of okadaic acid on histamine release from rat peritoneal mast cells activated by anti-IgE

, 1993
The effect of okadaic acid, a potent inhibitor of protein phosphatase 1 and 2A, on histamine release from mast cells has been investigated. Okadaic acid strongly and dose-dependently inhibited histamine release from mast cells induced by anti-IgE.
Koichi Endo, Masao Takei, Hideki Mitsui
core   +1 more source

19-epi-Okadaic Acid, a Novel Protein Phosphatase Inhibitor with Enhanced Selectivity

, 2016
A new protein phosphatase inhibitor, 19-epi-okadaic acid, was isolated from the marine dinoflagellate Prorocentrum belizeanum. Its structure and conformation in solution has been determined, and important differences were found when compared with the ...
Antonio Hernández Daranas (2473177), Manuel Norte (727840), Patricia G. Cruz (2473180), José J. Fernández (727841)   +3 more
core   +1 more source

First report of diarrheic shellfish toxins in mollusks from Buenos Aires Province (Argentina) associated with Dinophysis spp.: evidence of okadaic acid, dinophysistoxin-1 and their Acyl-derivatives

Boletín de la Sociedad Argentina de Botánica
 In January 2010, the toxin-producing dinoflagellates Dinophysis acuminata and D. caudata (103 cells·l-1) were detected in Mar Azul during routine plankton monitoring in Buenos Aires Province  coastal waters, Argentina.
Eugenia A. Sar, Inés Sunesen, Alejandra B. Goya, Andrea S. Lavigne, Eric Tapia, Carlos García, Néstor Lagos   +6 more
doaj   +1 more source

Quantitative Nuclear Magnetic Resonance Spectroscopy Based on PULCON Methodology: Application to Quantification of Invaluable Marine Toxin, Okadaic Acid

Toxins, 2016
ERETIC2 (Electronic Reference To access In vivo Concentrations 2) based on PULCON (Pulse Length–based Concentration determination) methodology is a quantitative NMR (qNMR) using an external standard.
Ryuichi Watanabe, Chika Sugai, Taichi Yamazaki, Ryoji Matsushima, Hajime Uchida, Masahiro Matsumiya, Akiko Takatsu, Toshiyuki Suzuki   +7 more
doaj   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source