Results 71 to 80 of about 14,228 (214)
Okadaic acid inhibits amylase exocytosis from parotid acini stimulated by cyclic AMP [PDF]
, 1991 To evaluate the role of protein phosphorylation in amylase exocytosis, we studied the effects of okadaic acid, a potent inhibitor of protein phosphatase types I and 2A, on amylase release and protein phosphorylation in rat parotid acini. Although okadaic
Taishin Takuma +3 more
core +1 more source
Advanced Functional Materials, Volume 36, Issue 52, 29 June 2026.We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins +9 more
wiley +1 more source
Minisatellite Instability Induced by Okadaic Acid.
THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN, 1997 Okadaic acid (OA) is an inhibitor of serine/threonine protein phosphatase (PP) and a tumor promoter in mouse skin carcinogenesis. According to Carcinogenesis Division, National Cancer Center Research Institute, OA induces various genetic alterations, such as loss of exogenous genes, sister chromatid exchanges and diphtheria toxin resistant mutants ...
openaire +3 more sources
Okadaic acid co−induces vimentin expression and cell cycle arrest in MPC−11 mouse plasmacytoma cells [PDF]
, 1994 he effect of the tumor promoter okadaic acid on cell cycle progression and on vimentin expression in MPC−11 mouse plasmacytoma cells was compared with that of the tumor promoter 12−O−tetradecanoylphorbol−13−acetate (TPA).
P. Traub +13 more
core +1 more source
Use of Okadaic Acid to Identify Relevant Phosphoepitopes in Pathology: A Focus on Neurodegeneration
Marine Drugs, 2013 Protein phosphorylation is involved in the regulation of a wide variety of physiological processes and is the result of a balance between protein kinase and phosphatase activities. Biologically active marine derived compounds have been shown to represent
Jesús Avila +2 more
doaj +1 more source
Detection of diarrheal shellfish toxins
Reviews in Analytical Chemistry, 2022 Seafood poisoning outbreaks are often caused by biotoxins generated by harmful algal blooms. Shellfish toxins, mainly derived from phytoplankton, cause diarrhea and poisoning in humans who consume contaminated seafood. Many studies suggest that diarrheal
Xu Rui +3 more
doaj +1 more source
Biosensors for Biotoxins Detection and Monitoring
Advanced Sensor Research, Volume 5, Issue 6, June 2026.This review examines state‐of‐the‐art biosensing platforms for biotoxin detection, including antibody‐, aptamer‐, CRISPR‐, nanopore‐, whole cells‐ and MIP‐based sensors. It highlights advances in ultra‐sensitive detection, real‐matrix validation in food and water, and multiplexed analysis, and discusses how the integration with machine learning ...
Alissa Agerova +2 more
wiley +1 more source
Okadaic acid stimulates IGF-II receptor translocation and inhibits insulin action in adipocytes [PDF]
, 1993 Okadaic acid, an inhibitor of protein phosphatases 2A and 1, stimulates glucose transport in muscle and fat cells, suggesting that serine/threonine phosphorylation steps are involved in the translocation of glucose transporters. Here we have investigated
E. Van Obberghen +4 more
core +1 more source
EFSA Journal, Volume 24, Issue 6, June 2026.Abstract Following a request from the European Commission, EFSA evaluated the effectiveness of sanitary shucking of queen scallops (Aequipecten opercularis) contaminated with okadaic acid (OA) group toxins. Specifically, EFSA was tasked to evaluate a study conducted by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES ...
European Food Safety Authority (EFSA) +6 more
wiley +1 more source
Effects of okadaic acid on the activities of two distinct phosphatidate phosphohydrolases in rat hepatocytes [PDF]
, 1992 Incubation of hepatocytes with okadaic acid displaced the N-ethylmaleimide-sensitive phosphatidate phosphohydrolase from the membrane fraction into the cytosol and partially prevented the oleate-induced movement of phosphohydrolase from cytosol to ...
Brindley, David N. +11 more
core +1 more source