Results 91 to 100 of about 14,228 (214)

Okadaic acid stimulates carnitine palmitoyltransferase I activity and palmitate oxidation in isolated rat hepatocytes [PDF]

, 1991
Okadaic acid increased in parallel with carnitine palmitoyltransferase I activity and the rate of palmitate oxidation in isolated rat hepatocytes. Nevertheless, okadaic acid had no significant effect on the rate of octanoate oxidation. Maximal effects of
Castro, José, Guzmán, Manuel, Manuel Guzmán, José Castro   +3 more
core   +1 more source

First report of diarrheic shellfish toxins in mollusks from Buenos Aires Province (Argentina) associated with Dinophysis spp.: evidence of okadaic acid, dinophysistoxin-1 and their Acyl-derivatives

Boletín de la Sociedad Argentina de Botánica
 In January 2010, the toxin-producing dinoflagellates Dinophysis acuminata and D. caudata (103 cells·l-1) were detected in Mar Azul during routine plankton monitoring in Buenos Aires Province  coastal waters, Argentina.
Eugenia A. Sar, Inés Sunesen, Alejandra B. Goya, Andrea S. Lavigne, Eric Tapia, Carlos García, Néstor Lagos   +6 more
doaj   +1 more source

Microcystins Alter Chemotactic Behavior in Caenorhabditis elegans by Selectively Targeting the AWA Sensory Neuron

Toxins, 2014
Harmful algal blooms expose humans and animals to microcystins (MCs) through contaminated drinking water. While hepatotoxicity following acute exposure to MCs is well documented, neurotoxicity after sub-lethal exposure is poorly understood. We developed
Caroline E. Moore, Pamela J. Lein, Birgit Puschner   +2 more
doaj   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

An Efficient Total Synthesis of Okadaic Acid [PDF]

, 2016
An Efficient Total Synthesis of Okadaic ...
Rebecca A. Urbanek (2004700), Craig J. Forsyth (1661140), Steven F. Sabes (3001659)   +2 more
core   +3 more sources

Quantitative Nuclear Magnetic Resonance Spectroscopy Based on PULCON Methodology: Application to Quantification of Invaluable Marine Toxin, Okadaic Acid

Toxins, 2016
ERETIC2 (Electronic Reference To access In vivo Concentrations 2) based on PULCON (Pulse Length–based Concentration determination) methodology is a quantitative NMR (qNMR) using an external standard.
Ryuichi Watanabe, Chika Sugai, Taichi Yamazaki, Ryoji Matsushima, Hajime Uchida, Masahiro Matsumiya, Akiko Takatsu, Toshiyuki Suzuki   +7 more
doaj   +1 more source

Safety of oil from Schizochytrium sp. A2 for use in infant and follow‐on formula as a novel food pursuant to regulation (EU) 2015/2283

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of an oil derived from the microalga‐like organism Schizochytrium sp. A2 as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Thomas Frenzel, Margarita Aguilera‐Gómez, Francesca Marcon, Monika Neuhäuser‐Berthold, Irene Nuin Garciarena, Emanuela Turla, Areti Favata, Karen Ildico Hirsch‐Ernst   +22 more
wiley   +1 more source

Okadaic acid inhibits activation of K-Cl cotransport in red blood cells containing hemoglobins S and C [PDF]

, 1991
The sensitivity of red blood cells containing hemoglobins S and C to activation of K-Cl cotransport by osmotic swelling and acidification was reduced by okadaic acid, a specific protein phosphatase inhibitor.
J. A. Whitney, J. S. Brockenbrough, J. C. Parker, P. S. Glosson, E. P. Orringer   +4 more
core   +1 more source

Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone

Aging Cell, Volume 25, Issue 4, April 2026.
Middle‐aged/older (MA/O) men with low testosterone have greater age‐related vascular endothelial dysfunction than MA/O with normal testosterone. This study highlights the potential role of mitochondrial dysfunction and reduced sirtuin 3, a key modulator of mitochondrial function and oxidative stress, in accelerated vascular aging in MA/O men with low ...
Branden L. Nguyen, Mackenzie N. Kehmeier, Matthew C. Babcock, Lyndsey E. DuBose, Kerry L. Hildreth, Brian L. Stauffer, Ryan Rosenberry, Amy C. Keller, Kira Steinke, Kaleb Miles, Lucas Guerrero, Wendy M. Kohrt, Jane Reusch, Zachary S. Clayton, Kerrie L. Moreau   +14 more
wiley   +1 more source

Marine toxins, food safety threats and One Health approach: cytotoxicity and intestinal bioavailability of okadaic acid in the porcine IPEC-J2 intestinal cell line [PDF]

reservedIn the context of One Health approach, which recognizes the interconnection between human, animal, and environmental health, marine biotoxins pose an increasing threat to food safety. Among these ones, okadaic acid (OA), a potent lipophilic toxin
CAROLLO, GIORGIA
core