Results 91 to 100 of about 3,497 (175)
Is Protein Phosphatase Inhibition Responsible for the Toxic Effects of Okadaic Acid in Animals?
Toxins, 2013 Okadaic acid (OA) and its derivatives, which are produced by dinoflagellates of the genera Prorocentrum and Dinophysis, are responsible for diarrhetic shellfish poisoning in humans.
Rex Munday
doaj +1 more source
, 2014 Recently, there has been increasing interest in certain low dalton marine toxins, as they have been implicated in seafood poisonings. The toxins include ciguatoxin (CTX), which is implicated in ciguatera fish poisoning, and okadaic acid (OA), which is ...
Hong, Terri-lynn
core
Bioscience, Biotechnology, and Biochemistry, 1994 The specificity of five mouse monoclonal antibodies to okadaic acid was studied for use in an enzyme-linked immunosorbent assay of okadaic acid and its analogs. OA8-2 and OA22-22 antibodies (IgG2a-kappa), which bind more strongly to dinophysistoxin-1 and 7-O-palmitoyl-dinophysistoxin-1 than to okaic acid or 7-O-palmitoyl-okadaic acid in 50% aqueous ...
Matsuura, Shiro +2 more
openaire +2 more sources
Formal Total Synthesis of Okadaic Acid via Regiocontrolled Gold(I)-Catalyzed Spiroketalizations
, 2016 Both C19 and C34 spiroketal domains of okadaic acid were assembled using gold(I) chloride catalyzed spiroketalizations, and the two resulting fragments were coupled to give the C15−C38 fragment of okadaic acid, a known intermediate for the total ...
Chao Fang (456315) +2 more
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Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response
, 2004 Microcystins, potent heptapeptide hepatotoxins produced by certain bloom-forming cyanobacteria, are strong protein phosphatase inhibitors. They covalently bind the serine/threonine protein phosphatases 1 and 2A (PP1 and PP2A), thereby influencing ...
Michelle M Gehringer +1 more
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Okadaic acid inhibits amylase exocytosis from parotid acini stimulated by cyclic AMP
, 1991 To evaluate the role of protein phosphorylation in amylase exocytosis, we studied the effects of okadaic acid, a potent inhibitor of protein phosphatase types I and 2A, on amylase release and protein phosphorylation in rat parotid acini. Although okadaic
Taishin Takuma +3 more
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Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans [PDF]
, 2001 Chicken xenobiotic receptor, pregnane X receptor, and constitutive androstane receptor are orphan nuclear receptors that have recently been discovered to regulate drug- and steroid-mediated induction of hepatic cytochromes P450 (CYP).
Stockli, J. +4 more
core
Okadaic acid co−induces vimentin expression and cell cycle arrest in MPC−11 mouse plasmacytoma cells
, 1994 he effect of the tumor promoter okadaic acid on cell cycle progression and on vimentin expression in MPC−11 mouse plasmacytoma cells was compared with that of the tumor promoter 12−O−tetradecanoylphorbol−13−acetate (TPA).
P. Traub +13 more
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Okadaic acid stimulates IGF-II receptor translocation and inhibits insulin action in adipocytes
, 1993 Okadaic acid, an inhibitor of protein phosphatases 2A and 1, stimulates glucose transport in muscle and fat cells, suggesting that serine/threonine phosphorylation steps are involved in the translocation of glucose transporters. Here we have investigated
E. Van Obberghen +4 more
core +1 more source
, 1992 Incubation of hepatocytes with okadaic acid displaced the N-ethylmaleimide-sensitive phosphatidate phosphohydrolase from the membrane fraction into the cytosol and partially prevented the oleate-induced movement of phosphohydrolase from cytosol to ...
Brindley, David N. +11 more
core +1 more source