Results 91 to 100 of about 22,039 (219)

Effect of okadaic acid on human basophil secretion

Biochemical Pharmacology, 1993
We examined the effects of a phosphatase inhibitor, okadaic acid, on mediator secretion from human basophils. These cells are known to respond to a number of stimuli that appear to utilize distinct biochemical pathways converging on mediator release.
L M, Botana, D W, MacGlashan
openaire   +2 more sources

Loss of p62 Binding Allows TIF‐IA Accumulation in Senescence, Which Promotes Phenotypic Changes to Nucleoli and the Senescence Associated Secretory Phenotype

Aging Cell, Volume 25, Issue 1, January 2026.
P62‐TIF‐IA–mediated regulation of senescence and ageing. In healthy tissue, p62 facilitates TIF‐IA turnover. Upon senescence induction, ATM activation increases TIF‐IA phosphorylation at S44, reducing its p62 binding and causing TIF‐IA accumulation.
Hazel C. Thoms, Tyler S. Brant, Katie Duckett, Yizheng Yang, Jinxi Dong, Hongfei Wang, Freya Derby, Oluwatumilara F. Akeke, Faizah Al‐Alayeen, Amy Newell, Piotr Manasterski, Aishwarya Gopalakrishnan, Derek Mann, Fraser R. Millar, Alex Von Kriegsheim, Juan Carlos Acosta, Fiona Oakley, Lesley A. Stark   +17 more
wiley   +1 more source

New Invertebrate Vectors of Okadaic Acid from the North Atlantic Waters—Portugal (Azores and Madeira) and Morocco

Toxins, 2015
Okadaic acid and its analogues are potent phosphatase inhibitors that cause Diarrheic Shellfish Poisoning (DSP) through the ingestion of contaminated shellfish by humans. This group of toxins is transmitted worldwide but the number of poisoning incidents
Marisa Silva, Inés Rodriguez, Aldo Barreiro, Manfred Kaufmann, Ana Isabel Neto, Meryem Hassouani, Brahim Sabour, Amparo Alfonso, Luis M. Botana, Vitor Vasconcelos   +9 more
doaj   +1 more source

Effects of fostriecin on β2-adrenoceptor-driven responses in human mast cells [PDF]

, 2017
As part of the intracellular processes leading to mast cell and basophil activation, phosphorylation of key substrates is likely to be important. These processes, mediated by phosphatases, are responsible for regulating phosphorylation.
Gilbert H, Hamidrez J. Ardakani, Nahid Eskandari, Peter T. Peachell, Reza Bastan   +4 more
core   +1 more source

Targeting Progesterone Receptor Membrane Component 1 to Improve Muscle Development and Glucose Homeostasis

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Type 2 diabetes mellitus (T2D) arises from the interplay between peripheral insulin resistance and pancreatic β‐cell dysfunction, ultimately leading to impaired glucose utilization and chronic hyperglycemia. Despite therapeutic advances, the multifactorial nature of T2D continues to demand the development of novel treatment ...
Sang R. Lee, Moeka Mukae, Globinna Kim, Jung‐Eun Park, Young Hoon Sung, Young Suk Won, Tae Won Kim, Hyo‐Jung Kwun, In‐Jeoung Baek, Eui‐Ju Hong   +9 more
wiley   +1 more source

Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c)

Marine Drugs, 2012
The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP).
José J. Fernández, Tamara S. Vilches, Manuel Norte, Antonio Hernández Daranas   +3 more
doaj   +1 more source

Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics. [PDF]

, 2018
Loss-of-function mutations in CDKL5 kinase cause severe neurodevelopmental delay and early-onset seizures. Identification of CDKL5 substrates is key to understanding its function.
Baltussen, Lucas L, Christodoulou, Evangelos, Claxton, Suzanne, Flynn, Helen R, Moeskops, Max, Muotri, Alysson R, Negraes, Priscilla D, Silvestre, Margaux, Snijders, Ambrosius P, Ultanir, Sila K   +9 more
core  

Natural compounds for pediatric cancer treatment [PDF]

, 2015
There is a tremendous need in clinics to impair cancer progression through noninvasive therapeutic approaches. The use of natural compounds to achieve this is of importance to improve the quality of life of young patients during their treatments.
Boffa, I, De Masi, G, Ferrucci, V, Zollo, M.   +3 more
core   +1 more source

NETosis‐Like Response Triggered by Extracellular Vesicle (EV)‐Delivered Viral Nucleic Acid, a Novel Cellular Immune Mechanism in Crustacean

Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
ABSTRACT As a novel identified manner of cell death, NETosis is widely regarded as an effective approach to resist pathogen infection but mainly focused on vertebrates with systematic cell typing. Besides, the role of extracellular vesicles (EVs), which are essential tools for intercellular information exchange, in regulating NETosis during pathogen ...
Hang Hu, Chunyi Zhong, Xinshan Zhao, Cheng Yi, Yi Gong   +4 more
wiley   +1 more source

Evaluation of the Impact of Mild Steaming and Heat Treatment on the Concentration of Okadaic Acid, Dinophysistoxin-2 and Dinophysistoxin-3 in Mussels

Toxins, 2016
This study explores the effect of laboratory and industrial steaming on mussels with toxin concentrations above and below the legal limit. We used mild conditions for steaming, 100 °C for 5 min in industrial processing, and up to 20 min in small-scale ...
Inés Rodríguez, Amparo Alfonso, Alvaro Antelo, Mercedes Alvarez, Luis M. Botana   +4 more
doaj   +1 more source