Expedient Access to the Okadaic Acid Architecture: A Novel Synthesis of the C1−C27 Domain [PDF]
, 2016 A newly designed synthetic entry to the C1−C27 domain of okadaic acid has been developed. This incorporates substantial improvements in the preparations of the key okadaic acid building blocks representing the C3−C8, C9−C14, and C16−C27 portions.
Rebecca A. Urbanek (2004700) +3 more
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Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism [PDF]
, 1989 Okadaic acid is a polyether derivative of 38-carbon fatty acid1, and is implicated as the causative agent of diarrhetic shellfish poisoning2. It is a potent tumour promoter that is not an activator of protein kinase C (ref.
D. Carling +13 more
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Frontiers in Aging NeuroscienceIntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by decreased memory and cognitive impairment. Abnormal tau hyperphosphorylation ultimately forms neurofibrillary tangles, which is one of the most important ...
Jiahui Li +6 more
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Okadaic acid does not impair T regulatory cell mediated suppression of CD4 effector cells. [PDF]
, 2017 (a) Teff and Tregs were isolated from the lymph nodes and spleen of FoxP3-GFP mice. Cells were co-cultured at indicated ratios in the presence of antigen presenting cells and 0.15 μg/mL anti-CD3 for 96 hours +/- okadaic acid.
Kodi Ravichandran (3818341) +3 more
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Current situation on analysis of marine toxins
Reviews in Analytical Chemistry, 2013 Marine toxins are a food safety concern worldwide. This review discusses current analytical methods for those toxins that are legally regulated in Europe, namely domoic acid, saxitoxin, okadaic acid, yessotoxin, pectenotoxin and azaspiracids, and all ...
Botana Ana M. +4 more
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The effects of okadaic acid on Enchytraeus crypticus (Annelida: Oligochaeta) [PDF]
Invertebrate Survival Journal, 2006 We describe the morpho-functional effects of different concentrations of okadaic acid (OA) on specimens of Enchytraeus crypticus. The results demonstrate that this experimental model is very sensitive to the treatment and presents time- and dose-related ...
A Franchini, M Marchetti
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Фактори експериментальної еволюції організмів, 2015 Aim. Okadaic acid (OA) strongly inhibits protein serine/threonine phosphatases PP1 and PP2A/2B. In comparison with the other inhibitors the inhibitory effect of OA is strongest for PP2A, followed by PP1, and then PP2B.
Д. А. Самофалова +2 more
doaj
The effect of okadaic acid on **Arabidopsis thaliana** root morphology and microtubule organization in its cells [PDF]
, 2009 : To investigate the role of protein hyperphosphorylation in plant cells, the effect of okadaic acid, a specific inhibitor of protein phosphatases PPI and PP2A, on the general morphology of Arabidopsis thaliana primary roots and the structural-functional
Sheremet, Ya. A. +3 more
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Okadaic Acid Is at Least as Toxic as Dinophysistoxin-1 after Repeated Administration to Mice by Gavage. [PDF]
Toxins (Basel), 2023 Park SY +6 more
europepmc +1 more source
Estudo da bioacumulação e eliminação do ácido ocadáico, produzido pelo dinoflagelado Prorocentrum lima, em mexilhões da espécie Perna perna (Mollusca:Bivalvia) [PDF]
, 2000 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.Nos últimos anos, o fenômeno conhecido como "maré vermelha", caracterizado por uma massiva proliferação de organismos pertencentes ao fitoplâncton que podem ser tóxicos ...
Lemieszek, Márcia Bonow
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