Results 41 to 50 of about 2,695,498 (213)
Toxicon: X, 2020 Numerous toxin-producing harmful algal (HAB) species occur in Florida's coastal waters. Exposure to these toxins has been shown to have sublethal effects in sea turtles.
Justin R. Perrault +5 more
doaj +1 more source
Transformation of a marine toxic polyether, okadaic acid. [PDF]
Agricultural and Biological Chemistry, 1988 Natural okadaic acid 1 was transformed into the 7, 24, 27-tri-0-benzyl-l, 2-acetonide derivative (4) in a 66% overall yidd. The corresponding synthetic derivative (4) was identified with this authentic sample.
ICHIKAWA, Yoshiyasu +2 more
openaire +2 more sources
VIEW, EarlyView.Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi +5 more
wiley +1 more source
Phosphorylation of BigH1 regulates its expression pattern and promotes embryonic development
The FEBS Journal, EarlyView.Phosphorylation is a key regulator of the linker histone variant BigH1 during Drosophila embryogenesis. We reveal that N‐terminal phosphorylation promotes the timely removal of BigH1 from chromatin. In contrast, C‐terminal phosphorylation supports early nuclear divisions and embryonic viability.
Ramóna Pék +9 more
wiley +1 more source
Real‐Time Neurochemical Sensing in Zebrafish: Electrochemical and Fluorescent Approaches
Analysis &Sensing, Volume 6, Issue 6, November 2026.The use of zebrafish has emerged as a powerful approach for real‐time neurochemical measurements. This review highlights recent advances in electrochemical and fluorescent sensing strategies that enable dynamic measurements in live preparations of this complex vertebrate. These complementary approaches provide new insights into neurochemical signaling,
Piyanka Hettiarachchi +2 more
wiley +1 more source
Toxicon: X, 2023 Oysters (Crassostrea virginica) were screened for 12 phycotoxins over two years in nearshore waters to collect baseline phycotoxin data and to determine prevalence of phycotoxin co-occurrence in the commercially and ecologically-relevant species.
Sarah K.D. Pease +12 more
doaj +1 more source
Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins [PDF]
The FEBS Journal, 2008 Okadaic acid (OA) and its analogs, the dinophysistoxins, are potent inhibitors of protein phosphatases 1 and 2A. This action is well known to cause diarrhea and gastrointestinal symptons when the toxins reach the digestive tract by ingestion of mollusks. A less well‐known effect of these group of toxins is their effect in the cytoskeleton.
Carmen, Vale, Luis M, Botana
openaire +2 more sources
Advanced Science, Volume 13, Issue 60, 28 October 2026.Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou +6 more
wiley +1 more source
Mass Spectral Characterisation of Three New Groups of Algal Toxins [PDF]
, 2009 This thesis reports the mass spectral identification and characterisation of three new groups of algal compounds. A series of novel pectenotoxins (PTXs) were identified in retained sub-samples of Irish mussel extracts that had previously been utilised ...
Knudsen, Brent Kevin
core
Formal Total Synthesis of Okadaic Acid via Regiocontrolled Gold(I)-Catalyzed Spiroketalizations
, 2016 Both C19 and C34 spiroketal domains of okadaic acid were assembled using gold(I) chloride catalyzed spiroketalizations, and the two resulting fragments were coupled to give the C15−C38 fragment of okadaic acid, a known intermediate for the total ...
Chao Fang (456315) +2 more
core +1 more source