Results 21 to 30 of about 14,228 (214)

Effect of okadaic acid on utilization of lipoprotein-derived cholesteryl esters by rat steroidogenic cells.

Journal of Lipid Research, 1994
This study examines various functional, biochemical, and structural changes in rat adrenocortical and ovarian granulosa cells that could account for the decline in lipoprotein-supported hormone production after cell treatment with the protein phosphatase
S Azhar, J A Frazier, L Tsai, E Reaven
doaj   +1 more source

Oral Toxicity of Okadaic Acid in Mice: Study of Lethality, Organ Damage, Distribution and Effects on Detoxifying Gene Expression

Toxins, 2013
In vivo, after administration by gavage to mice and rats, okadaic acid has been reported to produce lesions in liver, small intestine and forestomach.
Luis M. Botana, Félix V. Vega, Mercedes R. Vieytes, Paz Otero, José Manuel Cifuentes, Roberto Bermúdez, Amparo Alfonso, Henar López-Alonso, Andres C. Vieira, Juan A. Rubiolo   +9 more
doaj   +1 more source

Risk Assessment of Pectenotoxins in New Zealand Bivalve Molluscan Shellfish, 2009–2019

Toxins, 2020
Pectenotoxins (PTXs) are produced by Dinophysis spp., along with okadaic acid, dinophysistoxin 1, and dinophysistoxin 2. The okadaic acid group toxins cause diarrhetic shellfish poisoning (DSP), so are therefore regulated.
Michael J. Boundy, D Tim Harwood, Andreas Kiermeier, Cath McLeod, Jeane Nicolas, Sarah Finch   +5 more
doaj   +1 more source

Screening for Okadaic Acid by Immunoassay

Journal of AOAC INTERNATIONAL, 1995
Abstract Increasing incidences of phytoplankton blooms with the potential danger of toxin release into the food chain have necessitated the search for new diagnostic methods that can detect toxins quickly and reliably. A competitive enzymelinked immunosorbent assay (ELISA) was developed to quantitate okadaic acid in shellfish and ...
Chin, J. D., Quilliam, Michael A., Fremy, J. M., Mohapatra, S. K., Sikorska, H. M.   +4 more
openaire   +3 more sources

Evidence for physiological functions of protein phosphatases in the heart: evaluation with okadaic acid [PDF]

, 1993
Okadaic acid exerts a positive inotropic effect in cardiac preparations. We studied whether the positive inotropic effect of okadaic acid in cardiac preparations could be due to phosphatase inhibition and whether this inhibition affects the ...
A. M. Watanabe, S. Herzig, R. C. Gupta, J. Neumann, W. Schmitz, P. Boknik, H. Scholz   +6 more
core   +1 more source

Isoproterenol-induced dephosphorylation events in the presence of okadaic acid. [PDF]

, 2013
MEFs were pretreated with okadaic acid (1 μM) for 30 minutes and then were stimulated with isoproterenol (10 μM) for various times (0, 5, 10, 20, 30, or 60 minutes).
Steven M. Chan (493709), Paul J. Utz (416263), Harvir Singh (493708), Andrzej J. Chruscinski (493707)   +3 more
core   +1 more source

Solid phase extraction for removal of matrix effects in lipophilic marine toxin analysis by liquid chromatography-tandem mass spectrometry [PDF]

, 2009
The potential of solid phase extraction (SPE) clean-up has been assessed to reduce matrix effects (signal suppression or enhancement) in the liquid chromatography-tandem mass spectrometry (LC¿MS/MS) analysis of lipophilic marine toxins.
Boer, J., de, Bire, Ronel, Bire, R., de Boer, J., de Boer, J.; id_orcid, Jacob de Boer, Boer, J. de, Mulder, Patrick P. J., McElhinney, A. M., Hess, Philipp, McElhinney, M., Philipp Hess, Gerssen, A., Mairead A. McElhinney, Gerssen, Arjen, Ronel Bire, Arjen Gerssen, Bire, L., de Boer, Jacob, Patrick P. J. Mulder, Mulder, P.P.J., Hess, P., McElhinney, Mairead A.   +22 more
core   +1 more source

Modulation of macrophage scavenger receptor transport by protein phosphorylation

Journal of Lipid Research, 1996
The identification of three highly conserved phosphorylation sites in the cytoplasmic domain of each of the monomeric subunits of the macrophage scavenger receptor suggests that protein phosphorylation may regulate this receptor pathway.
L G Fong
doaj   +1 more source

Lipophilic Toxins in Wild Bivalves from the Southern Gulf of California, Mexico

Marine Drugs, 2021
Most of the shellfish fisheries of Mexico occur in the Gulf of California. In this region, known for its high primary productivity, blooms of diatoms and dinoflagellates are common, occurring mainly during upwelling events.
Ignacio Leyva-Valencia, Jesús Ernestina Hernández-Castro, Christine J. Band-Schmidt, Andrew D. Turner, Alison O’Neill, Erick J. Núñez-Vázquez, David J. López-Cortés, José J. Bustillos-Guzmán, Francisco E. Hernández-Sandoval   +8 more
doaj   +1 more source

Okadaic acid, a phosphatase inhibitor, decreases macrophage motility [PDF]

, 1991
Cellular locomotion results from a series of spatially and temporally integrated reactions. The coordinated regulation of these reactions requires sensitive intracellular signaling mechanisms.
A. Takai, P. de Lanerolle, J. C. Ruegg, A. K. Wilson   +3 more
core   +1 more source