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Okadaic Acid Is a Potent Angiogenesis Inducer [PDF]
Japanese Journal of Cancer Research, 1992 Okadaic acid, which is a non‐12‐0‐tetradecanoylphorbol‐13‐acetate (TPA)‐type tumor promoter and an inhibitor of protein phosphatases 1 and 2A, induced angiogenesis in the chorioallantoic membrane of the chick embryo. Its potent angiogenic activity was dose‐dependent. The minimum effective dose was 5 fmol/egg and the effective dose for 50% induction was
Oikawa, Tsutomu +3 more
openaire +2 more sources
The insect, Galleria mellonella, is a compatible model for evaluating the toxicology of okadaic acid [PDF]
, 2019 The polyether toxin, okadaic acid, causes diarrhetic shellfish poisoning in humans. Despite extensive research into its cellular targets using rodent models, we know little about its putative effect(s) on innate immunity.
Andrew Rowley +8 more
core +1 more source
Nucleus, 2020 Elastic tethers, connecting telomeres of all separating anaphase chromosome pairs, lose elasticity when they lengthen during anaphase. Treatment with phosphatase inhibitor CalyculinA causes anaphase chromosomes to move backwards after they reach the ...
Emma Kite, Arthur Forer
doaj +1 more source
Okadaic acid influences xenobiotic metabolism in HepaRG cells
EXCLI Journal : Experimental and Clinical Sciences, 2022 Okadaic acid (OA) is an algae-produced lipophilic marine biotoxin that accumulates in the fatty tissue of filter-feeding shellfish. Ingestion of contaminated shellfish leads to the diarrheic shellfish poisoning syndrome.
Leonie T. D. Wuerger +5 more
doaj +1 more source
Journal of Lipid Research, 1994 This study examines various functional, biochemical, and structural changes in rat adrenocortical and ovarian granulosa cells that could account for the decline in lipoprotein-supported hormone production after cell treatment with the protein phosphatase
S Azhar, J A Frazier, L Tsai, E Reaven
doaj +1 more source
Toxins, 2013 In vivo, after administration by gavage to mice and rats, okadaic acid has been reported to produce lesions in liver, small intestine and forestomach.
Luis M. Botana +9 more
doaj +1 more source
Risk Assessment of Pectenotoxins in New Zealand Bivalve Molluscan Shellfish, 2009–2019
Toxins, 2020 Pectenotoxins (PTXs) are produced by Dinophysis spp., along with okadaic acid, dinophysistoxin 1, and dinophysistoxin 2. The okadaic acid group toxins cause diarrhetic shellfish poisoning (DSP), so are therefore regulated.
Michael J. Boundy +5 more
doaj +1 more source
Proteomic analysis of hepatic effects of okadaic acid in HepaRG human liver cells
EXCLI Journal : Experimental and Clinical Sciences, 2023 The marine biotoxin okadaic acid (OA) is produced by dinoflagellates and enters the human food chain by accumulating in the fatty tissue of filter-feeding shellfish.
Leonie T. D. Wuerger +4 more
doaj +1 more source
Simple Diffusion as the Mechanism of Okadaic Acid Uptake by the Mussel Digestive Gland
Toxins, 2019 Okadaic acid (OA) and other toxins of the diarrheic shellfish poisoning (DSP) group are accumulated and transformed mainly in many bivalves, inside the digestive gland cells.
Juan Blanco +3 more
doaj +1 more source
Okadaic Acid Depuration from the Cockle Cerastoderma edule
Toxins, 2022 The cockle Cerastoderma edule is a commercially important species in many European Countries. It can accumulate okadaic acid (OA) and other toxins in its group, which makes it unsuitable for human consumption, producing harvesting bans to avoid ...
Juan Blanco +3 more
doaj +1 more source