Risk Assessment of Pectenotoxins in New Zealand Bivalve Molluscan Shellfish, 2009–2019
Toxins, 2020 Pectenotoxins (PTXs) are produced by Dinophysis spp., along with okadaic acid, dinophysistoxin 1, and dinophysistoxin 2. The okadaic acid group toxins cause diarrhetic shellfish poisoning (DSP), so are therefore regulated.
Michael J. Boundy +5 more
doaj +1 more source
The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm [PDF]
, 2016 Sperm capacitation is required for fertilization. At the molecular level, this process is associated with fast activation of protein kinase A. Downstream of this event, capacitating conditions lead to an increase in tyrosine phosphorylation. The identity
Alvau, Antonio +13 more
core +1 more source
IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]
, 2014 The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S +19 more
core +1 more source
Lipophilic Toxins in Wild Bivalves from the Southern Gulf of California, Mexico
Marine Drugs, 2021 Most of the shellfish fisheries of Mexico occur in the Gulf of California. In this region, known for its high primary productivity, blooms of diatoms and dinoflagellates are common, occurring mainly during upwelling events.
Ignacio Leyva-Valencia +8 more
doaj +1 more source
Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1). [PDF]
, 2017 The small phosphoprotein pCPI-17 inhibits myosin light-chain phosphatase (MLCP). Current models postulate that during muscle relaxation, phosphatases other than MLCP dephosphorylate and inactivate pCPI-17 to restore MLCP activity.
Eto, Masumi +4 more
core +2 more sources
Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. [PDF]
, 2018 Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors ...
Beckendorf, Lisa +10 more
core +3 more sources
Okadaic Acid Is a Potent Angiogenesis Inducer [PDF]
Japanese Journal of Cancer Research, 1992 Okadaic acid, which is a non‐12‐0‐tetradecanoylphorbol‐13‐acetate (TPA)‐type tumor promoter and an inhibitor of protein phosphatases 1 and 2A, induced angiogenesis in the chorioallantoic membrane of the chick embryo. Its potent angiogenic activity was dose‐dependent. The minimum effective dose was 5 fmol/egg and the effective dose for 50% induction was
Oikawa, Tsutomu +3 more
openaire +2 more sources
Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]
, 2014 International audienceAims/Hypothesis: Reduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve ...
A El-Yassimi +52 more
core +12 more sources
Modulation of macrophage scavenger receptor transport by protein phosphorylation
Journal of Lipid Research, 1996 The identification of three highly conserved phosphorylation sites in the cytoplasmic domain of each of the monomeric subunits of the macrophage scavenger receptor suggests that protein phosphorylation may regulate this receptor pathway.
L G Fong
doaj +1 more source
Simultaneous Effect of Temperature and Irradiance on Growth and Okadaic Acid Production from the Marine Dinoflagellate Prorocentrum belizeanum [PDF]
, 2014 Benthic marine dioflagellate microalgae belonging to the genus Prorocentrum are a major source of okadaic acid (OA), OA analogues and polyketides. However, dinoflagellates produce these valuable toxins and bioactives in tiny quantities, and they grow ...
Belarbi, El Hassan +6 more
core +3 more sources