Results 21 to 30 of about 2,695,498 (213)
The insect, Galleria mellonella, is a compatible model for evaluating the toxicology of okadaic acid [PDF]
, 2019 The polyether toxin, okadaic acid, causes diarrhetic shellfish poisoning in humans. Despite extensive research into its cellular targets using rodent models, we know little about its putative effect(s) on innate immunity.
Andrew Rowley +8 more
core +1 more source
Mechanism of the stimulatory action of okadaic acid on lipolysis in rat fat cells
Journal of Lipid Research, 2000 Okadaic acid was found to induce concentration- and time-dependent lipolysis in rat fat cells in the absence of lipolytic hormones, but it did not significantly increase the total hormone-sensitive lipase (HSL) activity in these fat cells, the activity ...
Chie Morimoto +5 more
doaj +1 more source
Okadaic Acid Is a Potent Angiogenesis Inducer [PDF]
Japanese Journal of Cancer Research, 1992 Okadaic acid, which is a non‐12‐0‐tetradecanoylphorbol‐13‐acetate (TPA)‐type tumor promoter and an inhibitor of protein phosphatases 1 and 2A, induced angiogenesis in the chorioallantoic membrane of the chick embryo. Its potent angiogenic activity was dose‐dependent. The minimum effective dose was 5 fmol/egg and the effective dose for 50% induction was
Oikawa, Tsutomu +3 more
openaire +2 more sources
Journal of Lipid Research, 1994 This study examines various functional, biochemical, and structural changes in rat adrenocortical and ovarian granulosa cells that could account for the decline in lipoprotein-supported hormone production after cell treatment with the protein phosphatase
S Azhar, J A Frazier, L Tsai, E Reaven
doaj +1 more source
Nucleus, 2020 Elastic tethers, connecting telomeres of all separating anaphase chromosome pairs, lose elasticity when they lengthen during anaphase. Treatment with phosphatase inhibitor CalyculinA causes anaphase chromosomes to move backwards after they reach the ...
Emma Kite, Arthur Forer
doaj +1 more source
Risk Assessment of Pectenotoxins in New Zealand Bivalve Molluscan Shellfish, 2009–2019
Toxins, 2020 Pectenotoxins (PTXs) are produced by Dinophysis spp., along with okadaic acid, dinophysistoxin 1, and dinophysistoxin 2. The okadaic acid group toxins cause diarrhetic shellfish poisoning (DSP), so are therefore regulated.
Michael J. Boundy +5 more
doaj +1 more source
Modulation of macrophage scavenger receptor transport by protein phosphorylation
Journal of Lipid Research, 1996 The identification of three highly conserved phosphorylation sites in the cytoplasmic domain of each of the monomeric subunits of the macrophage scavenger receptor suggests that protein phosphorylation may regulate this receptor pathway.
L G Fong
doaj +1 more source
Lipophilic Toxins in Wild Bivalves from the Southern Gulf of California, Mexico
Marine Drugs, 2021 Most of the shellfish fisheries of Mexico occur in the Gulf of California. In this region, known for its high primary productivity, blooms of diatoms and dinoflagellates are common, occurring mainly during upwelling events.
Ignacio Leyva-Valencia +8 more
doaj +1 more source
BMC Pharmacology and Toxicology, 2017 Background Exposure to chemicals might be toxic to the developing brain. There is a need for simple and robust in vitro cellular models for evaluation of chemical-induced neurotoxicity as a complement to traditional studies on animals.
Dina Popova +2 more
doaj +1 more source
Chinese Journal of Physiology, 2020 PKC-mediated inflammation is important in ovarian physiology. The roles of Akt and protein phosphatase 2A (PP2A) in PKC-mediated inflammation in ovarian granulosa cells (GCs) remain mostly unclear.
Yen-Yu Lin, David Sun, Yuh-Lin Wu
doaj +1 more source