Identification of Dynamic Changes in Proteins Associated with the Cellular Cytoskeleton after Exposure to Okadaic Acid [PDF]
Marine Drugs, 2013 Exposure of cells to the diarrhetic shellfish poison, okadaic acid, leads to a dramatic reorganization of cytoskeletal architecture and loss of cell-cell contact.
Peter Roepstorff +5 more
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Toxins, 2018 Mycotoxins are emerging toxins in the marine environment, which can co-occur with algal toxins to exert synergistic or antagonistic effects for human seafood consumption.
Aiko Hayashi +3 more
doaj +3 more sources
Screening for Okadaic Acid by Immunoassay
Journal of AOAC INTERNATIONAL, 1995 Abstract Increasing incidences of phytoplankton blooms with the potential danger of toxin release into the food chain have necessitated the search for new diagnostic methods that can detect toxins quickly and reliably. A competitive enzymelinked immunosorbent assay (ELISA) was developed to quantitate okadaic acid in shellfish and ...
Chin, J. D. +4 more
openaire +4 more sources
Kolaviron neuroprotective effect against okadaic acid-provoked cognitive impairment [PDF]
HeliyonAlzheimer's disease (AD) is acknowledged as the main causative factor of dementia that affects millions of people around the world and is increasing at increasing pace.
Morteza Nazari-Serenjeh +9 more
doaj +2 more sources
Diverse Bacterial PKS Sequences Derived From Okadaic Acid-Producing Dinoflagellates [PDF]
Marine Drugs, 2008 Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously ...
Kathleen S. Rein +4 more
doaj +2 more sources
Promotion of BALB/3T3 Cell Transformation by the Okadaic Acid Class of Tumor Promoters, Okadaic Acid and Dinophysistoxin-1 [PDF]
Japanese Journal of Cancer Research, 1991 Okadaic acid and dinophysistoxin‐1 are non‐12‐O‐tetradecanoylphorbol‐13‐acetate (non‐TPA)‐type tumor promoters, which enhance chemically induced tumorigenesis on mouse skin through a different mechanism from that of TPA. In the present study, we examined the promoting effects of these okadaic acid class tumor promoters on a two‐stage transformation ...
Hirota Fujiki
exaly +3 more sources
Is Protein Phosphatase Inhibition Responsible for the Toxic Effects of Okadaic Acid in Animals?
Toxins, 2013 Okadaic acid (OA) and its derivatives, which are produced by dinoflagellates of the genera Prorocentrum and Dinophysis, are responsible for diarrhetic shellfish poisoning in humans.
Rex Munday
doaj +3 more sources
Neuroprotective Studies of Evodiamine in an Okadaic Acid-Induced Neurotoxicity [PDF]
International Journal of Molecular Sciences, 2021 Chia-Ron Yang
exaly +2 more sources
Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria
Frontiers in Cellular Neuroscience, 2022 Microtubule-based transport provides mitochondria to distant regions of neurons and is essential for neuronal health. To identify compounds that increase mitochondrial motility, we screened 1,641 small-molecules in a high-throughput screening platform ...
Keunjung Heo +11 more
doaj +1 more source
High Value Phycotoxins From the Dinoflagellate Prorocentrum
Frontiers in Marine Science, 2021 Marine dinoflagellates produce chemically diverse compounds, with a wide range of biological activity (antimicrobial, anticancer, treatment of neurodegenerative disease along with use as biomedical research tools).
Dolores Camacho-Muñoz +3 more
doaj +1 more source