Okadaic Acid: A Tool to Study the Hippo Pathway [PDF]
Marine Drugs, 2013 Mammalian Ste20-like kinases 1 and 2 (MST1 and MST2) are activated in NIH3T3 cells exposed to okadaic acid. The Hippo pathway is a newly emerging signaling that functions as a tumor suppressor.
Yutaka Hata +2 more
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Identification of Dynamic Changes in Proteins Associated with the Cellular Cytoskeleton after Exposure to Okadaic Acid [PDF]
Marine Drugs, 2013 Exposure of cells to the diarrhetic shellfish poison, okadaic acid, leads to a dramatic reorganization of cytoskeletal architecture and loss of cell-cell contact.
Peter Roepstorff +5 more
doaj +3 more sources
Combined Cytotoxicity of the Phycotoxin Okadaic Acid and Mycotoxins on Intestinal and Neuroblastoma Human Cell Models [PDF]
Toxins, 2018 Mycotoxins are emerging toxins in the marine environment, which can co-occur with algal toxins to exert synergistic or antagonistic effects for human seafood consumption.
Aiko Hayashi +3 more
doaj +4 more sources
Diverse Bacterial PKS Sequences Derived From Okadaic Acid-Producing Dinoflagellates [PDF]
Marine Drugs, 2008 Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously ...
Kathleen S. Rein +4 more
doaj +3 more sources
The insect, Galleria mellonella, is a compatible model for evaluating the toxicology of okadaic acid. [PDF]
Cell Biol Toxicol, 2019 The polyether toxin, okadaic acid, causes diarrhetic shellfish poisoning in humans. Despite extensive research into its cellular targets using rodent models, we know little about its putative effect(s) on innate immunity.
Coates CJ +6 more
europepmc +3 more sources
Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria
Frontiers in Cellular Neuroscience, 2022 Microtubule-based transport provides mitochondria to distant regions of neurons and is essential for neuronal health. To identify compounds that increase mitochondrial motility, we screened 1,641 small-molecules in a high-throughput screening platform ...
Keunjung Heo +11 more
doaj +1 more source
High Value Phycotoxins From the Dinoflagellate Prorocentrum
Frontiers in Marine Science, 2021 Marine dinoflagellates produce chemically diverse compounds, with a wide range of biological activity (antimicrobial, anticancer, treatment of neurodegenerative disease along with use as biomedical research tools).
Dolores Camacho-Muñoz +3 more
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Mechanism of the stimulatory action of okadaic acid on lipolysis in rat fat cells
Journal of Lipid Research, 2000 Okadaic acid was found to induce concentration- and time-dependent lipolysis in rat fat cells in the absence of lipolytic hormones, but it did not significantly increase the total hormone-sensitive lipase (HSL) activity in these fat cells, the activity ...
Chie Morimoto +5 more
doaj +1 more source
Okadaic Acid Is a Potent Angiogenesis Inducer [PDF]
Japanese Journal of Cancer Research, 1992 Okadaic acid, which is a non‐12‐0‐tetradecanoylphorbol‐13‐acetate (TPA)‐type tumor promoter and an inhibitor of protein phosphatases 1 and 2A, induced angiogenesis in the chorioallantoic membrane of the chick embryo. Its potent angiogenic activity was dose‐dependent. The minimum effective dose was 5 fmol/egg and the effective dose for 50% induction was
Oikawa, Tsutomu +3 more
openaire +2 more sources
Nucleus, 2020 Elastic tethers, connecting telomeres of all separating anaphase chromosome pairs, lose elasticity when they lengthen during anaphase. Treatment with phosphatase inhibitor CalyculinA causes anaphase chromosomes to move backwards after they reach the ...
Emma Kite, Arthur Forer
doaj +1 more source