Results 11 to 20 of about 3,497 (175)
Okadaic Acid: A Tool to Study the Hippo Pathway [PDF]
Marine Drugs, 2013 Mammalian Ste20-like kinases 1 and 2 (MST1 and MST2) are activated in NIH3T3 cells exposed to okadaic acid. The Hippo pathway is a newly emerging signaling that functions as a tumor suppressor.
Yutaka Hata +2 more
doaj +4 more sources
Okadaic Acid: More than a Diarrheic Toxin [PDF]
Marine Drugs, 2013 Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary intoxications.
Josefina Méndez +4 more
doaj +6 more sources
Identification of Dynamic Changes in Proteins Associated with the Cellular Cytoskeleton after Exposure to Okadaic Acid [PDF]
Marine Drugs, 2013 Exposure of cells to the diarrhetic shellfish poison, okadaic acid, leads to a dramatic reorganization of cytoskeletal architecture and loss of cell-cell contact.
Peter Roepstorff +5 more
doaj +2 more sources
Toxins, 2018 Mycotoxins are emerging toxins in the marine environment, which can co-occur with algal toxins to exert synergistic or antagonistic effects for human seafood consumption.
Aiko Hayashi +3 more
doaj +3 more sources
Diverse Bacterial PKS Sequences Derived From Okadaic Acid-Producing Dinoflagellates
Marine Drugs, 2008 Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously ...
Kathleen S. Rein +4 more
doaj +3 more sources
Utilizing zebrafish and okadaic acid to study Alzheimer’s disease [PDF]
Neural Regeneration Research, 2018 Despite the many years of extensive research using rodent models to study Alzheimer’s disease (AD), no cure or disease halting drug exists. An increasing number of people are suffering from the disease and a therapeutic intervention is needed. Therefore,
Daniel Koehler, Frederick E Williams
doaj +2 more sources
Toxins, 2021 The mussel Mytilus galloprovincialis is one of the most important aquaculture species in Europe. Its main production problem is the accumulation of toxins during coastal blooms, which prevents mussel commercialization. P-glycoprotein (ABCB1/MDR1/P-gp) is
Roi Martínez-Escauriaza +5 more
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Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria
Frontiers in Cellular Neuroscience, 2022 Microtubule-based transport provides mitochondria to distant regions of neurons and is essential for neuronal health. To identify compounds that increase mitochondrial motility, we screened 1,641 small-molecules in a high-throughput screening platform ...
Keunjung Heo +11 more
doaj +1 more source
High Value Phycotoxins From the Dinoflagellate Prorocentrum
Frontiers in Marine Science, 2021 Marine dinoflagellates produce chemically diverse compounds, with a wide range of biological activity (antimicrobial, anticancer, treatment of neurodegenerative disease along with use as biomedical research tools).
Dolores Camacho-Muñoz +3 more
doaj +1 more source
Mechanism of the stimulatory action of okadaic acid on lipolysis in rat fat cells
Journal of Lipid Research, 2000 Okadaic acid was found to induce concentration- and time-dependent lipolysis in rat fat cells in the absence of lipolytic hormones, but it did not significantly increase the total hormone-sensitive lipase (HSL) activity in these fat cells, the activity ...
Chie Morimoto +5 more
doaj +1 more source