Results 31 to 40 of about 2,695,498 (213)
The inhibitory effects of okadaic acid on platelet function [PDF]
FEBS Letters, 1992 Okadaic acid (OA), a potent inhibitor of protein phosphatases type 1 and type 2A, inhibited thrombin‐induced platelet aggregation (IC50 = 0.8 μM), [14C]serotonin release and increase in intracellular Ca2+ ([Ca2+]i) in the same dose dependence. In the absence of thrombin OA increased the phosphorylation of 50‐kDa protein and 20‐kDa myosin light chain ...
Higashihara, Masaaki +3 more
openaire +2 more sources
Retrovirology, 2005 Background HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consisting of CDK9 and cyclin T1, to HIV-1 transactivation response (TAR) RNA.
Brady John +4 more
doaj +1 more source
Love wave biosensor for real-time detection of okadaic acid as DSP phycotoxin
, 2010 Love wave acoustic delay lines were used as sensors for okadaic acid immuno-detection through immobilized specific antibodies. Anti-okadaic acid antibodies were grafted onto the sensor surface.
C. Dejous +21 more
core +1 more source
19-epi-Okadaic Acid, a Novel Protein Phosphatase Inhibitor with Enhanced Selectivity
, 2007 A new protein phosphatase inhibitor, 19-epi-okadaic acid, was isolated from the marine dinoflagellate Prorocentrum belizeanum. Its structure and conformation in solution has been determined, and important differences were found when compared with the ...
Hernández Daranas, Antonio +3 more
core +1 more source
Determination of Lipophilic Marine Biotoxins in Mussels Harvested from the Adriatic Sea by LC-MS/MS
Frontiers in Microbiology, 2018 Lipophilic marine biotoxins include okadaic acid, pectenotoxin, yessotoxin and azaspiracid groups. The consumption of contaminated molluscs can lead to acute food poisoning syndromes depending on the exposure level.
Maria Schirone +8 more
doaj +1 more source
Dinophysis Toxins: Distribution, Fate in Shellfish and Impacts
Toxins, 2019 Several planktonic dinoflagellate species of the genus Dinophysis produce one or two groups of lipophilic toxins: (i) okadaic acid (OA) and its derivatives, the dinophysistoxins (DTXs), and (ii) pectenotoxins (PTXs) [...]
Beatriz Reguera, Juan Blanco
doaj +1 more source
19-epi-Okadaic Acid, a Novel Protein Phosphatase Inhibitor with Enhanced Selectivity
, 2016 A new protein phosphatase inhibitor, 19-epi-okadaic acid, was isolated from the marine dinoflagellate Prorocentrum belizeanum. Its structure and conformation in solution has been determined, and important differences were found when compared with the ...
Antonio Hernández Daranas (2473177) +3 more
core +1 more source
Advanced Electronic Materials, EarlyView.This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler +4 more
wiley +1 more source
Phytotherapy Research, EarlyView.Rh1 attenuates oxidative stress and mitochondrial dysfunction through SIRT1‐related signaling. ABSTRACT Alzheimer's disease (AD) remains a progressive neurodegenerative disorder with limited therapeutic options. Ginsenoside Rh1 has been reported to possess neuroprotective properties, yet its specific role and underlying mechanisms in AD are not fully ...
Shi‐Lu Li +10 more
wiley +1 more source
Effect of okadaic acid on histamine release from rat peritoneal mast cells activated by anti-IgE
, 1993 The effect of okadaic acid, a potent inhibitor of protein phosphatase 1 and 2A, on histamine release from mast cells has been investigated. Okadaic acid strongly and dose-dependently inhibited histamine release from mast cells induced by anti-IgE.
Koichi Endo, Masao Takei, Hideki Mitsui
core +1 more source