Results 31 to 40 of about 3,497 (175)

In Vitro Interactions between Okadaic Acid and Rat Gut Microbiome

Marine Drugs, 2022
Okadaic acid (OA) is a marine biotoxin associated with diarrhetic shellfish poisoning (DSP), posing some threat to human beings. The oral toxicity of OA is complex, and the mechanism of toxicity is not clear. The interaction between OA and gut microbiota
Yang Liu, Siyuan Xu, Qiudie Cai, Dawei Li, Hongye Li, Weidong Yang   +5 more
doaj   +1 more source

Screening for Okadaic Acid by Immunoassay

Journal of AOAC INTERNATIONAL, 1995
Abstract Increasing incidences of phytoplankton blooms with the potential danger of toxin release into the food chain have necessitated the search for new diagnostic methods that can detect toxins quickly and reliably. A competitive enzymelinked immunosorbent assay (ELISA) was developed to quantitate okadaic acid in shellfish and ...
Chin, J. D., Quilliam, Michael A., Fremy, J. M., Mohapatra, S. K., Sikorska, H. M.   +4 more
openaire   +3 more sources

Lipophilic Toxins in Wild Bivalves from the Southern Gulf of California, Mexico

Marine Drugs, 2021
Most of the shellfish fisheries of Mexico occur in the Gulf of California. In this region, known for its high primary productivity, blooms of diatoms and dinoflagellates are common, occurring mainly during upwelling events.
Ignacio Leyva-Valencia, Jesús Ernestina Hernández-Castro, Christine J. Band-Schmidt, Andrew D. Turner, Alison O’Neill, Erick J. Núñez-Vázquez, David J. López-Cortés, José J. Bustillos-Guzmán, Francisco E. Hernández-Sandoval   +8 more
doaj   +1 more source

Solid phase extraction for removal of matrix effects in lipophilic marine toxin analysis by liquid chromatography-tandem mass spectrometry [PDF]

, 2009
The potential of solid phase extraction (SPE) clean-up has been assessed to reduce matrix effects (signal suppression or enhancement) in the liquid chromatography-tandem mass spectrometry (LC¿MS/MS) analysis of lipophilic marine toxins.
Boer, J., de, Bire, Ronel, Bire, R., de Boer, J., de Boer, J.; id_orcid, Jacob de Boer, Boer, J. de, Mulder, Patrick P. J., McElhinney, A. M., Hess, Philipp, McElhinney, M., Philipp Hess, Gerssen, A., Mairead A. McElhinney, Gerssen, Arjen, Ronel Bire, Arjen Gerssen, Bire, L., de Boer, Jacob, Patrick P. J. Mulder, Mulder, P.P.J., Hess, P., McElhinney, Mairead A.   +22 more
core   +1 more source

Modulation of macrophage scavenger receptor transport by protein phosphorylation

Journal of Lipid Research, 1996
The identification of three highly conserved phosphorylation sites in the cytoplasmic domain of each of the monomeric subunits of the macrophage scavenger receptor suggests that protein phosphorylation may regulate this receptor pathway.
L G Fong
doaj   +1 more source

The inhibitory effects of okadaic acid on platelet function [PDF]

FEBS Letters, 1992
Okadaic acid (OA), a potent inhibitor of protein phosphatases type 1 and type 2A, inhibited thrombin‐induced platelet aggregation (IC50 = 0.8 μM), [14C]serotonin release and increase in intracellular Ca2+ ([Ca2+]i) in the same dose dependence. In the absence of thrombin OA increased the phosphorylation of 50‐kDa protein and 20‐kDa myosin light chain ...
Higashihara, Masaaki, Takahata, Kyoya, Kurokawa, Kiyoshi, Ikebe, Mitsuo   +3 more
openaire   +2 more sources

Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription

Retrovirology, 2005
Background HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consisting of CDK9 and cyclin T1, to HIV-1 transactivation response (TAR) RNA.
Brady John, Debebe Zufan, Washington Kareem, Ammosova Tatyana, Nekhai Sergei   +4 more
doaj   +1 more source

Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical- and toxin-induced neurotoxicity

BMC Pharmacology and Toxicology, 2017
Background Exposure to chemicals might be toxic to the developing brain. There is a need for simple and robust in vitro cellular models for evaluation of chemical-induced neurotoxicity as a complement to traditional studies on animals.
Dina Popova, Jessica Karlsson, Stig O. P. Jacobsson   +2 more
doaj   +1 more source

Novel regulation of PKC-induced inflammation by Akt and protein phosphatase 2A in ovarian granulosa cells

Chinese Journal of Physiology, 2020
PKC-mediated inflammation is important in ovarian physiology. The roles of Akt and protein phosphatase 2A (PP2A) in PKC-mediated inflammation in ovarian granulosa cells (GCs) remain mostly unclear.
Yen-Yu Lin, David Sun, Yuh-Lin Wu
doaj   +1 more source

Determination of Lipophilic Marine Biotoxins in Mussels Harvested from the Adriatic Sea by LC-MS/MS

Frontiers in Microbiology, 2018
Lipophilic marine biotoxins include okadaic acid, pectenotoxin, yessotoxin and azaspiracid groups. The consumption of contaminated molluscs can lead to acute food poisoning syndromes depending on the exposure level.
Maria Schirone, Miriam Berti, Pierina Visciano, Francesco Chiumiento, Giacomo Migliorati, Rosanna Tofalo, Giovanna Suzzi, Federica Di Giacinto, Nicola Ferri   +8 more
doaj   +1 more source