Results 31 to 40 of about 14,228 (214)

Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical- and toxin-induced neurotoxicity

BMC Pharmacology and Toxicology, 2017
Background Exposure to chemicals might be toxic to the developing brain. There is a need for simple and robust in vitro cellular models for evaluation of chemical-induced neurotoxicity as a complement to traditional studies on animals.
Dina Popova, Jessica Karlsson, Stig O. P. Jacobsson   +2 more
doaj   +1 more source

Effects of okadaic acid indicate a role for dephosphorylation in pancreatic stimulus-secretion coupling [PDF]

, 1992
Okadaic acid completely inhibits phosphatase 2A at nanomolar concentrations, while complete inhibition of type 1 phosphatases occurs at 1 microM. Phosphatase 2B is significantly inhibited only at concentrations > 1 microM.
A. C. Wagner, J. A. Williams, M. J. Wishart, D. I. Yule   +3 more
core   +1 more source

Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription

Retrovirology, 2005
Background HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consisting of CDK9 and cyclin T1, to HIV-1 transactivation response (TAR) RNA.
Brady John, Debebe Zufan, Washington Kareem, Ammosova Tatyana, Nekhai Sergei   +4 more
doaj   +1 more source

Novel regulation of PKC-induced inflammation by Akt and protein phosphatase 2A in ovarian granulosa cells

Chinese Journal of Physiology, 2020
PKC-mediated inflammation is important in ovarian physiology. The roles of Akt and protein phosphatase 2A (PP2A) in PKC-mediated inflammation in ovarian granulosa cells (GCs) remain mostly unclear.
Yen-Yu Lin, David Sun, Yuh-Lin Wu
doaj   +1 more source

The inhibitory effects of okadaic acid on platelet function [PDF]

FEBS Letters, 1992
Okadaic acid (OA), a potent inhibitor of protein phosphatases type 1 and type 2A, inhibited thrombin‐induced platelet aggregation (IC50 = 0.8 μM), [14C]serotonin release and increase in intracellular Ca2+ ([Ca2+]i) in the same dose dependence. In the absence of thrombin OA increased the phosphorylation of 50‐kDa protein and 20‐kDa myosin light chain ...
Higashihara, Masaaki, Takahata, Kyoya, Kurokawa, Kiyoshi, Ikebe, Mitsuo   +3 more
openaire   +2 more sources

Love wave biosensor for real-time detection of okadaic acid as DSP phycotoxin [PDF]

, 2010
Love wave acoustic delay lines were used as sensors for okadaic acid immuno-detection through immobilized specific antibodies. Anti-okadaic acid antibodies were grafted onto the sensor surface.
C. Dejous, Moynet, D., Mossalayi, D., Fournel, F., M. Degueil, Degueil, Marie, L. Vellutini, Bennetau, B., Vellutini, Luc, Dejous, Corinne, Rebiere, D., D. Moynet, Mamani-Matsuda, M., Pillot, Jean-Paul, F. Fournel, M. Mamani-Matsuda, Dejous, C., Baco, E., Pillot, J.-P., Rebière, Dominique, D. Rebiere, Vellutini, L., E. Baco, J.-P. Pillot, Mossalayi, Djavad, D. Mossalayi, Moynet, Daniel, B. Bennetau, Bennetau, Bernard, Mamani-Matsuda, Maria, Fournel, Fabien, Baco, Etienne, Degueil, M.   +32 more
core   +1 more source

Determination of Lipophilic Marine Biotoxins in Mussels Harvested from the Adriatic Sea by LC-MS/MS

Frontiers in Microbiology, 2018
Lipophilic marine biotoxins include okadaic acid, pectenotoxin, yessotoxin and azaspiracid groups. The consumption of contaminated molluscs can lead to acute food poisoning syndromes depending on the exposure level.
Maria Schirone, Miriam Berti, Pierina Visciano, Francesco Chiumiento, Giacomo Migliorati, Rosanna Tofalo, Giovanna Suzzi, Federica Di Giacinto, Nicola Ferri   +8 more
doaj   +1 more source

Transformation of a marine toxic polyether, okadaic acid. [PDF]

Agricultural and Biological Chemistry, 1988
Natural okadaic acid 1 was transformed into the 7, 24, 27-tri-0-benzyl-l, 2-acetonide derivative (4) in a 66% overall yidd. The corresponding synthetic derivative (4) was identified with this authentic sample.
ICHIKAWA, Yoshiyasu, ISOBE, Minoru, GOTO, Toshio   +2 more
openaire   +2 more sources

Specific binding of okadaic acid, a new tumor promoter in mouse skin [PDF]

, 1989
The tumor promoter okadaic acid binds specifically to a particulate as well as a cytosolic fraction of various mouse tissues, e.g., skin, brain, lung and colon.
Fujiki, Hirota, Masami Suganuma, Makoto Ojika, Yamada, Kiyoyuki, Hirota Fujiki, Suganuma, Masami, Suttajit, Maitree, Maitree Suttajit, Suguri, Hiroko, Hiroko Suguri, Ojika, Makoto, Kiyoyuki Yamada   +11 more
core   +1 more source

Dinophysis Toxins: Distribution, Fate in Shellfish and Impacts

Toxins, 2019
Several planktonic dinoflagellate species of the genus Dinophysis produce one or two groups of lipophilic toxins: (i) okadaic acid (OA) and its derivatives, the dinophysistoxins (DTXs), and (ii) pectenotoxins (PTXs) [...]
Beatriz Reguera, Juan Blanco
doaj   +1 more source