Results 171 to 180 of about 22,727 (219)

Okadaic Acid Increases ARNT Homodimer Transactivation Potential

Cell Biology and Toxicology, 2002
The human aryl hydrocarbon nuclear translocator (hARNT) protein belongs to the family of basic helix-loop-helix (bHLH) PAS transcription factors and regulates a range of cellular processes by either homodimerizing or heterodimerizing with other bHLH-PAS proteins. hARNT has been shown to be almost exclusively phosphorylated on serine residues.
S L, Levine, G H, Perdew
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Effect of Okadaic Acid on Glucose Regulation

Mini-Reviews in Medicinal Chemistry, 2005
Okadaic acid is the main toxin responsible for the natural phenomena known as diarrheic shellfish poisoning (DSP). This toxin is a tumor promoter C38 polyether fatty acid that contains acidic and hydrophobic moieties and is cyclic. Okadaic acid is a potent inhibitor of important classes of protein serine/threonine phosphatases such as protein ...
M C, Louzao, M R, Vieytes, L M, Botana
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Okadaic acid in mussels of Adriatic sea

Marine Pollution Bulletin, 1992
Abstract The diarrethic shellfish poisoning from mussels, collected in the main producing areas in the seawater off the coast of Emilia-Romagna (Italy), has been investigated. The ether soluble material from hepatopancreas of highly toxic mussels (Mytilus galloprovincialis) was partitioned between n-hexane and methanol-water 9:1.
FATTORUSSO, ERNESTO, CIMINIELLO, PATRIZIA, COSTANTINO, VALERIA, MAGNO, GIUSEPPINA SILVANA, MANGONI, ALFONSO, A. MILANDRI, R. POLETTI, M. POMPEI, R. VIVIANI   +8 more
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Calpain activation in okadaic-acid-induced neurodegeneration

NeuroReport, 2006
Calpain activation has been implicated in the pathogenesis of Alzheimer's disease. Okadaic acid, a protein phosphatase-2A inhibitor, has been used in Alzheimer's disease research models to increase tau phosphorylation and induce neuronal death. We previously reported that okadaic acid induced predominant activation of caspase-3 in immature neurons, but
SeungYong, Yoon, JungEun, Choi, Jae-Wan, Huh, Onyou, Hwang, DongHou, Kim   +4 more
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Complexation of okadaic acid : A preliminary study

Bioorganic & Medicinal Chemistry Letters, 1998
A complexation study was carried out with okadaic acid (OA) and the univalent metal ions Li+, Na+ and K+, and the divalent metal ions Ca2+ and Mg2+. K+ binding was observed identical with a complex obtained from the natural source (OAC). The pharmacological trials demonstrated that this cation has a very important influence on the pharmacological ...
M, Norte, J J, Fernández, M L, Souto, J A, Gavín, M L, Candenas, P, Ausina   +5 more
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Effects of Okadaic Acid on Rat Colon

Digestive Diseases and Sciences, 1998
Effects of okadaic acid (OA) on mucosal damage were examined in rat colon. OA was sprinkled on rat colon mucosa under observation with an electronic-endoscopic system, and OA was also applied to the in vivo microscopic field. The OA-induced changes in transepithelial conductance (Gt) were measured by the Ussing voltage clamp technique.
M, Hosokawa, H, Tsukada, T, Saitou, M, Kodama, M, Onomura, H, Nakamura, K, Fukuda, Y, Seino   +7 more
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Biotherapeutic Potential and Synthesis of Okadaic Acid

2000
Nature has long provided an array of secondary metabolites that have been utilized by man or humans for a large variety of therapeutic applications. The poly ether marine natural product okadaic acid (OA, Fig. 1) represents a particularly interesting example, with a rich modern history whose drama is continuing to unfold (Scheuer 1995).
C J, Forsyth, A B, Dounay, S F, Sabes, R A, Urbanek   +3 more
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Okadaic acid enhances abnormal phosphorylation on tau proteins

Neuroscience Letters, 1993
Tau proteins are one of the microtubule-associated proteins (MAPs) and show promoting activity on microtubule assembly. Tau proves to be the major constituent of Alzheimer's paired helical filaments, in which tau is found to be different from normal tau in that it is abnormally phosphorylated.
Y, Furiya, N, Sahara, H, Mori
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Specificity of Mouse Monoclonal Anti-Okadaic Acid Antibodies to Okadaic Acid and Its Analogs among Diarrhetic Shellfish Toxins

Bioscience, Biotechnology, and Biochemistry, 1994
The specificity of five mouse monoclonal antibodies to okadaic acid was studied for use in an enzyme-linked immunosorbent assay of okadaic acid and its analogs. OA8-2 and OA22-22 antibodies (IgG2a-kappa), which bind more strongly to dinophysistoxin-1 and 7-O-palmitoyl-dinophysistoxin-1 than to okaic acid or 7-O-palmitoyl-okadaic acid in 50% aqueous ...
S, Matsuura, H, Kita, Y, Takagaki
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Okadaic acid inhibits phosphatidylethanolamine biosynthesis in rat hepatocytes

Biochemical and Biophysical Research Communications, 1992
Okadaic acid, a specific inhibitor of protein phosphatase 1 and 2A, inhibited the synthesis of phosphatidylethanolamine via the CDPethanolamine pathway in isolated hepatocytes. Pulse-chase experiments and measurement of the enzyme activity demonstrated that the inhibition of phosphatidylethanolamine synthesis was not caused by an inhibition of CTP ...
L B, Tijburg, P S, Vermeulen, M G, Schmitz, L M, van Golde   +3 more
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