Results 21 to 30 of about 84,234 (301)

Physiologically‐Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan

CPT: Pharmacometrics & Systems Pharmacology, 2020
A combination of the antipsychotic olanzapine and the opioid receptor antagonist samidorphan (OLZ/SAM) is intended to provide the antipsychotic efficacy of olanzapine while mitigating olanzapine‐associated weight gain.
Lei Sun, Lisa vonMoltke, Karen Rowland Yeo   +2 more
doaj   +1 more source

Efficacy of olanzapine long-acting injection in patients with acutely exacerbated schizophrenia: an insight from effect size comparison with historical oral data

BMC Psychiatry, 2012
Background To treat acute schizophrenia, a long-acting injectable antipsychotic needs a rapid onset of action and therapeutic profile similar to that of oral agents.
Detke Holland C, Zhao Fangyi, Witte Michael M   +2 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Olanzapine induced tardive dyskinesia

Medical Journal of Dr. D.Y. Patil University, 2014
Olanzapine is considered to have significantly less risk of tardive dyskinesia (TD) compared to first generation antipsychotics. We describe two patients who developed TD after prolonged use of olanzapine.
Rudraprosad Chakraborty, Arunima Chatterjee, Suprakash Chaudhury   +2 more
doaj   +1 more source

Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes

eLife, 2020
Second-generation antipsychotics are widely used to medicate patients with schizophrenia, but may cause metabolic side effects such as diabetes, which has been considered to result from obesity-associated insulin resistance.
Satoshi Ninagawa, Seiichiro Tada, Masaki Okumura, Kenta Inoguchi, Misaki Kinoshita, Shingo Kanemura, Koshi Imami, Hajime Umezawa, Tokiro Ishikawa, Robert B Mackin, Seiji Torii, Yasushi Ishihama, Kenji Inaba, Takayuki Anazawa, Takahiko Nagamine, Kazutoshi Mori   +15 more
doaj   +1 more source

Pancreatitis following Olanzapine Therapy: A Report of Three Cases [PDF]

, 2007
CONTEXT: Atypical antipsychotic agents (clozapine, olanzapine) have been linked to metabolic effects and acute pancreatitis. CASE REPORT: We reviewed the inpatient and outpatient records of three patients who developed acute pancreatitis while being ...
Azar, Riad, Jonnalagadda, Sreenivasa, Kerr, Thomas A., Prakash, Chandra   +3 more
core   +4 more sources

Olanzapine pamoate use for schizophrenia: Retrospective records based study from a tertiary care hospital

Indian Journal of Psychological Medicine, 2020
Background: Little is known from India about the experience of using olanzapine long-acting antipsychotic injectables (LAI). In this background, this study aimed to evaluate the clinical profile of patients suffering from schizophrenia who were ...
Sandeep Grover, Himanshu Singla, Subho Chakrabarti, Ajit Avasthi   +3 more
doaj   +1 more source

Rare and Underestimated Association of Pulmonary Embolism and Olanzapine Therapy; Report of Two Cases

Archives of Academic Emergency Medicine, 2021
: Venous thromboembolic disease (VTD) is a very common and severe pathological condition in which there are many predisposing factors. Olanzapine is a drug frequently used in psychiatric practises; it is thought to increase the risk of VTD.
Hammam Rasras, Mustapha Beghi, Maryem Samti, Nabila Ismaili, Noha El Ouafi   +4 more
doaj   +1 more source

The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients [PDF]

, 2008
We investigated the relationships between functional genetic variants of the 5-HT(2C) receptor and multidrug-resistant protein (MDR1), coding for P-glycoprotein, and second generation antipsychotic (SDA)-induced weight gain among 108 female schizophrenic
Bilušić, Hrvoje, Božina, Nada, Hotujac, Ljubomir, Medved, Vesna, Rojnić Kuzman, Martina, Šain, Ivica   +5 more
core   +1 more source

Increased Appetite Plays a Key Role in Olanzapine-Induced Weight Gain in First-Episode Schizophrenia Patients

Frontiers in Pharmacology, 2020
Weight gain and metabolic disturbances, potentially influenced by increased appetite, are common effects of olanzapine treatment in patients with schizophrenia.
Jing Huang, G. Hei, Ye Yang, Chenchen Liu, Jingmei Xiao, Y. Long, Xingjie Peng, Yi Yang, Jing-ping Zhao, Ren-rong Wu   +9 more
semanticscholar   +1 more source