Results 41 to 50 of about 41,944 (264)

Olaparib Induces RPL5/RPL11-Dependent p53 Activation via Nucleolar Stress

Frontiers in Oncology, 2022
The poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) Olaparib is a widely used targeted therapy for a variety of solid tumors with homologous recombination deficiency (HRD) caused by mutation of BRCA1/2 or other DNA repair genes.
Tao Han, Jing Tong, Jing Tong, Mengxin Wang, Yu Gan, Bo Gao, Jiaxiang Chen, Youxun Liu, Qian Hao, Qian Hao, Xiang Zhou, Xiang Zhou, Xiang Zhou, Xiang Zhou   +13 more
doaj   +1 more source

Niraparib in ovarian cancer. results to date and clinical potential [PDF]

, 2017
Ovarian cancer is the first cause of death from gynaecological malignancy. Germline mutation in BRCA1 and 2, two genes involved in the mechanisms of reparation of DNA damage, are showed to be related with the incidence of breast and ovarian cancer, both ...
Benedetti Panici, Pierluigi, Caruso, Davide, Papa, Anselmo, Tomao, Federica, Tomao, Silverio, Vici, Patrizia   +5 more
core   +1 more source

TBCRC 048: Phase II Study of Olaparib for Metastatic Breast Cancer and Mutations in Homologous Recombination-Related Genes.

Journal of Clinical Oncology, 2020
PURPOSE Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi), is approved for the treatment of human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) in germline (g)BRCA1/2 mutation carriers.
N. Tung, M. Robson, Steffen Ventz, C. Santa-Maria, R. Nanda, P. Marcom, P. Shah, T. Ballinger, E. Yang, S. Vinayak, M. Melisko, A. Brufsky, M. DeMeo, Colby Jenkins, S. Domchek, A. D’Andrea, N. Lin, M. Hughes, L. Carey, N. Wagle, G. Wulf, I. Krop, A. Wolff, E. Winer, J. Garber   +24 more
semanticscholar   +1 more source

A Quaternary Solid Dispersion System for Improving the Solubility of Olaparib

Solids
To improve the low solubility of poorly water soluble olaparib, in the following study, we prepared olaparib-loaded quaternary solid dispersions with hypromellose, Tween 20 or Labrasol, and colloidal silica.
Tae-Han Yun, Jeong-Gyun Lee, Kyu-Ho Bang, Jung-Hyun Cho, Kyeong-Soo Kim   +4 more
doaj   +1 more source

Oligo-Fucoidan supplementation enhances the effect of Olaparib on preventing metastasis and recurrence of triple-negative breast cancer in mice

Journal of Biomedical Science, 2022
Background Seaweed polysaccharides have been recommended as anticancer supplements and for boosting human health; however, their benefits in the treatment of triple-negative breast cancers (TNBCs) and improving immune surveillance remain unclear ...
Li-Mei Chen, Pao-Pao Yang, Aushia Tanzih Al Haq, Pai-An Hwang, You-Chen Lai, Yueh-Shan Weng, Michelle Audrey Chen, Hsin-Ling Hsu   +7 more
doaj   +1 more source

The next steps in improving the outcomes of advanced ovarian cancer [PDF]

, 2015
Worldwide ovarian cancer affects over 200,000 women per year. Overall survival rates are poor due to two predominate reasons. First, the majority of patients present with advanced disease creating significant difficulty with effecting disease eradication.
Blagden, S, Fotopoulou, C, Gabra, H, Openshaw, MR   +3 more
core   +1 more source

Evolutionary dynamics of cancer multidrug resistance in response to olaparib and photodynamic therapy

Translational Oncology, 2021
P-glycoprotein (P-gp) is an adenosine triphosphate (ATP)-dependent drug efflux protein commonly associated with multidrug resistance in cancer chemotherapy.
Yan Baglo, Aaron J. Sorrin, Xiaocong Pu, Cindy Liu, Jocelyn Reader, Dana M. Roque, Huang-Chiao Huang   +6 more
doaj   +1 more source

GBM radiosensitizers: dead in the water…or just the beginning? [PDF]

, 2017
The finding that most GBMs recur either near or within the primary site after radiotherapy has fueled great interest in the development of radiosensitizers to enhance local control.
Bindra, Ranjit S., Chalmers, Anthony J., Dewhirst, Mark, Evans, Sydney   +3 more
core   +1 more source

Palladacarboxamide Capping Reagents for Carbon Isotope Labeling and Pharmaceutical Diversification

Angewandte Chemie, EarlyView.
Herein, we present a method for carbon isotope labeling of arylamides via the coupling of air‐stable palladium carboxamide complexes and boronic ester/acids. A wide variety of functionalized boronic esters and acids have been coupled with simple palladium carboxamides complexes.
Daniel V. Hoffmann, Anika Schick, Lasse Kjær, Vitus J. Enemærke, Clemens Kaussler, Jens Torp, Pablo Martínez‐Pardo, Charles S. Elmore, Troels Skrydstrup   +8 more
wiley   +2 more sources

MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC

Journal of Hematology & Oncology, 2020
Background PARP inhibitors have been the most promising target drugs with widely proven benefits among ovarian cancer patients. Although platinum-response, HR-related genes, or HRD genomic scar detection are acceptably used in assessment of Olaparib ...
Chenggong Sun, Wenyu Cao, Chunping Qiu, Chengcheng Li, Samina Dongol, Zhiwei Zhang, Ruifen Dong, Kun Song, Xingsheng Yang, Qing Zhang, Beihua Kong   +10 more
doaj   +1 more source