Results 71 to 80 of about 25,067 (205)

The efficacy and safety of PARP inhibitors in mCRPC with HRR mutation in second-line treatment: a systematic review and bayesian network meta-analysis

BMC Cancer
Background Poly (ADP- ribose) polymerase inhibitors (PARPi) has been increasingly adopted for metastatic castration-resistance prostate cancer (mCRPC) patients with homologous recombination repair deficiency (HRD).
Qiyu Zhu, Junru Chen, Haoyang Liu, Jinge Zhao, Chenhao Xu, Guangxi Sun, Hao Zeng   +6 more
doaj   +1 more source

Limb Compression Therapy and Chemotherapy‐Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self‐Controlled Study(NEURO‐GLOVE Trial)

International Journal of Cancer, EarlyView.
With no effective drug‐based prevention strategies available for chemotherapy‐induced peripheral neuropathy (CIPN), research in neuroprotective approaches has grown. Of particular interest is mechanical compression, which may protect nerves by temporarily reducing blood flow during treatment. The authors here conducted a prospective trial in women with
Kadriye Başkurt, Galip Can Uyar, Enes Yeşilbaş, Fatma Zehra Altunç, Damla Erimhan Çevik, İsmet Murat Melek, Yasemin Eren, Ömür Berna Çakmak Öksüzoğlu, Kadriye Bir Yücel, Antonio Di Meglio, Isabelle Ray‐Coquard, Osman Sütcüoğlu   +11 more
wiley   +1 more source

Olaparib for Metastatic Castration-Resistant Prostate Cancer

, 2020
Contains fulltext : 220820.pdf (Publisher’s version ) (Open Access)BACKGROUND: Multiple loss-of-function alterations in genes that are involved in DNA repair, including homologous recombination repair, are associated with response to ...
Kohlmann, A., Shore, Neal, Kohlmann, A, Shore, N, Mateo, J, Fizazi, K, Sandhu, S., Fizazi, K., Sandhu, S, Kang, Jinyu, Saad, F, Olmos, David, Twardowski, P., Sartor, Oliver, Mehra, N., Hussain, M., Mateo, Joaquin, Burgents, Joseph, Sartor, O, Olmos, D., Sandhu, Shahneen, Fizazi, Karim, Kohlmann, Alexander, Saad, Fred, de Bono, Johann, Adelman, Carrie A, Adelman, CA, Goessl, Carsten, Olmos, D, Thiery-Vuillemin, Antoine, Thiery-Vuillemin, A, Burgents, J, Thiery-Vuillemin, A., Twardowski, P, Hussain, Maha, Chi, Kim N, Mehra, Niven, Mateo, J., Burgents, J., Shore, N., Chi, KN, Agarwal, N, Wu, W., de Bono, J, Goessl, C, Chi, K.N., Wu, W, Sartor, O., Goessl, C., Adelman, Caroline, Mehra, N, Hussain, M, Agarwal, Neeraj, Twardowski, Przemyslaw, Kang, J., Kang, J, de-Bono, Johann, Wu, Wenting, Saad, F., Bono, J. de, Agarwal, N.   +60 more
core   +1 more source

Maintenance olaparib in patients with newly diagnosed advanced ovarian cancer [PDF]

, 2018
BACKGROUND: Most women with newly diagnosed advanced ovarian cancer have a relapse within 3 years after standard treatment with surgery and platinum-based chemotherapy.
Oza, Amit, Bradley, William, Banerjee, Susana, Scambia, Giovanni, Colombo, Nicoletta, Sonke, Gabe S., Mathews, Cara, Oaknin, Ana, Bloomfield, Ralph, Scambia, G., Kim, Byoung-Gie, Gonzalez-Martin, Antonio, Lowe, Elizabeth S., Moore, Kathleen, Aghajanian, Carol, DiSilvestro, Paul, Lisyanskaya, Alla, Floquet, Anne, Liu, Joyce, Friedlander, Michael, Leary, Alexandra, Gourley, Charlie   +21 more
core   +1 more source

Combinations of ATR, Chk1 and Wee1 inhibitors with Olaparib are active in Olaparib resistant Brca1 proficient and deficient murine ovarian cells

, 2022
Simple Summary Poly(ADP-ribose) polymerases inhibitors (PARPis), including olaparib, have been recently approved for ovarian carcinoma treatment and PARPi resistance has already been observed in the clinics.
Chiappa, Michela, Damia, Giovanna, Lupi, Monica, Anselmi, Martina, Guffanti, Federica, Panini, Nicolò, Wiesmüller, Lisa   +6 more
core   +1 more source

Clinical Implementation and Oncological Relevance of Molecular Profiling in Brain Metastases Patients—A Multicenter Retrospective Cohort Study

International Journal of Cancer, EarlyView.
While current guidelines recommend the analysis of established cancer driver genes in brain metastases, little is known about its real‐life implementation. This multicenter study revealed an upward trend in the profiling rates of surgically treated brain metastases over the past decade, with up to 60% of brain metastases samples undergoing analysis ...
Maria Nikolaeva, Jacopo Bellomo, Meltem Gönel, Vittorio Stumpo, Victor Egon Staartjes, Flavio Vasella, Kevin Akeret, André Sagerer, Anna Maria Zeitlberger, David Wasilewski, Christopher Krämer, Sven König, Julia Onken, Tareq Juratli, Alexander Köpp, Regina Reimann, Marcus Czabanka, Peter Vajkoczy, Ilker Y. Eyüpoglu, Oliver Bozinov, Michael Weller, Emilie Le Rhun, Luca Regli, Carlo Serra, Marian C. Neidert, Stefanos Voglis   +25 more
wiley   +1 more source

α2,3‐Sialyltransferase (ST3Gal1) regulates endometrioid‐type epithelial ovarian cancer cell migration and invasion via VEGF‐R2/JAK2/STAT3 signaling cascades

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the role of ST3 β‐galactoside α‐2,3‐sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF‐R2) in endometrioid‐type epithelial ovarian cancer (E‐OC) because aberrant α2,3‐sialylation mediated by ST3Gal1 and VEGF‐R2‐related angiogenesis is linked with tumor progression. Methods ST3Gal1 and
Wei‐Ting Chao, Chia‐Hao Liu, Szu‐Ting Yang, Chen‐Hao Lin, Liang‐Wei Wang, Peng‐Hui Wang   +5 more
wiley   +1 more source

Olaparib in the management of ovarian cancer

, 2015
Kristin Bixel,1 John L Hays2 1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, 2Department of Hematology Oncology, Ohio State University, Columbus, OH, USAAbstract: Alterations in the homologous repair pathway are thought to ...
Bixel K, Hays JL
core  

PCN95 cost-effectiveness analysis of germline BRCA mutation testing and olaparib treatment in metastatic breast cancer: an evaluation of codependent technologies

, 2019
Objectives: Genetic testing for a germline BRCA mutation in women with HER2-negative metastatic breast cancer (MBC) can guide targeted treatment with PARP inhibitors (e.g.
Tuffaha, H., Tuffaha, H, Scuffham, P, Scuffham, P.   +3 more
core   +1 more source

The poly (ADP-ribose) polymerase inhibitor olaparib attenuates established pulmonary fibrosis in a large animal model

BMC Pulmonary Medicine
Background Poly (ADP‒ribose) polymerase (PARP) is a constitutive enzyme involved in regulating various biological processes in health and disease. In the present study, we investigated the role of PARP1 in pulmonary fibrosis and assessed the efficacy of ...
Habtamu B. Derseh, Andrew N. Davies, Alarna Young, Sylvie Bischof, Joseph Pelle, David Rudd, Michelle McIntosh, David Piedrafita, Robert J. Bischof   +8 more
doaj   +1 more source