Results 61 to 70 of about 301,945 (302)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Climate change threatens old-growth forests in the Northern Alps

Environmental Research Letters
Old-growth forests are of high habitat value for many forest-dwelling species and of high cultural value for society. In areas with a long history of human land-use, such as in Central Europe, few old-growth forests remain, located predominately in ...
Rupert Seidl, Dominik Thom, Sebastian Seibold, Michael Maroschek, Werner Rammer   +4 more
doaj   +1 more source

Restoration in degraded subtropical broadleaved forests induces changes in soil bacterial communities

Global Ecology and Conservation, 2021
Soil resident bacterial communities are involved in myriad key processes that facilitate ecosystem functionality. However, our understanding of their diversity and compositional dynamics following ecological restoration, and the main factors that ...
Yuhua Ma, Chun Feng, Zhaocheng Wang, Cheng Huang, Xingzhao Huang, Wenjing Wang, Shaobo Yang, Songling Fu, Han Y.H. Chen   +8 more
doaj   +1 more source

Tropical secondary forest regeneration conserves high levels of avian phylogenetic diversity [PDF]

, 2017
Secondary forests are promoted as having pivotal roles in reversing the tropical extinction crisis. While secondary forests recover carbon and species over time, a key question is whether phylogenetic diversity—the total evolutionary history across all ...
Aide, Anderson, Barlow, Barton, Basham, Bates, Chazdon, Chazdon, Crk, David P. Edwards, Dávalos, Edwards, Edwards, Edwards, Edwards, Endress, Etter, Faith, Flynn, Frishkoff, Gardner, Gaston, Giam, Gibbs, Gibson, Gilroy, Gilroy, Gilroy, Hackett, Hansen, Helmer, Hill, Hothorn, James J. Gilroy, Jarvis, Jetz, Jetz, Kembel, Laurance, Michael R. Massam, Myers, Nakagawa, Paradis, Pavoine, Poorter, Prescott, Prum, Queiroz, Raboin, Sekercioglu, Sloan, Socolar, Swenson, Sánchez-Cuervo, Torbjørn Haugaasen, Tscharntke, Turner, Webb, Winter   +58 more
core   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Old-growth forests: what do we know about their ecology and management in the Southwest and Rocky Mountain Regions? [PDF]

, 1992
This paper reviews the science and management of old-growth forests and summarizes discussions among 30 participants at a workshop in Portal, Arizona, March 9-13, 1992.
Covington, W.W., Kaufmann, M.R., Moir, W.H.   +2 more
core  

Understory Vegetation in Old-Growth and Second-Growth Tsuga Canadensis Forests in Western Massachusetts [PDF]

, 2010
We compared the understory communities (herbs, shrubs, and tree seedlings and saplings) of old-growth and second-growth eastern hemlock forests (Tsuga canadensis) in western Massachusetts, USA. Second-growth hemlock forests originated following clear-cut
D’Amato, Anthony W., Foster, David Russell, Orwig, David A.   +2 more
core   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Mapping Individual Tree- and Plot-Level Biomass Using Handheld Mobile Laser Scanning in Complex Subtropical Secondary and Old-Growth Forests

Remote Sensing
Forests are invaluable natural resources that provide essential ecosystem services, and their carbon storage capacity is critical for climate mitigation efforts.
Nelson Pak Lun Mak, Tin Yan Siu, Ying Ki Law, He Zhang, Shaoti Sui, Fung Ting Yip, Ying Sim Ng, Yuhao Ye, Tsz Chun Cheung, Ka Cheong Wa, Lap Hang Chan, Kwok Yin So, Billy Chi Hang Hau, Calvin Ka Fai Lee, Jin Wu   +14 more
doaj   +1 more source

Patterns of forest dynamics in a secondary old-growth beech-dominated forest in the Jizera Mountains Beech Forest Reserve, Czech Republic

iForest - Biogeosciences and Forestry, 2019
Restoring the structural characteristics of secondary old-growth forests that were previously managed is increasingly debated to help increase the area of more complex forests which provide a broader array of forest services and functions. The paucity of
Lábusová J, Morrissey RC, Trotsiuk V, Janda P, Bače R, Cada V, Mikoláš M, Mrhalová H, Schurman JS, Svobodová K, Mateju L, Synek M, Svoboda M   +12 more
doaj   +1 more source