Results 71 to 80 of about 64,188 (295)

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Understory restoration in Hamilton urban forests

, 2011
Research was undertaken to determine how the understory vegetation of Hamilton urban forests compares with reference old-growth forests in rural locations, identify causes for differences, and develop methods to enhance species diversity.
Miller, Kieran Troy
core  

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Old-Growth Forests in the Context of International Environmental Agreements

, 2009
The United Nations (UN) Framework Convention on Climate Change (UNFCCC), the Convention on Biological Diversity (CBD), and the UN Forum on Forests (UNFF) are the most important international environmental agreements to include forests. Old-growth forests
Freibauer, Annette, Annette Freibauer, Freibauer, A.   +2 more
core   +1 more source

Environmental change impacts on the C- and N-cycle of European forests: a model comparison study [PDF]

, 2013
Forests are important components of the greenhouse gas balance of Europe. There is considerable uncertainty about how predicted changes to climate and nitrogen deposition will perturb the carbon and nitrogen cycles of European forests and thereby alter ...
De Vries, Wim, Werner, Christian R., Haas, E., R. Grote, M. Van Oijen, Butterbach-Bahl, K., H. I. Reuter, Kros, J., G. J. Reinds, Reuter, H. I., Werner, Christian, Leip, A., Grote, Rüdiger, Reinds, G.J., M. Kuhnert, Oijen, M., Van, Oijen, Marcel van, Vries, W., de, C. Werner, W. De Vries, Heuvelink, G.B.M., E. Haas, Reinds, Gert Jan, K. Butterbach-Bahl, Butterbach-Bahl, Klaus, Kuhnert, M., Haas, Edwin, Cameron, D.R., Cameron, David R., Yeluripati, Jagadeesh, Kuhnert, Matthias, Heuvelink, G. B. M., Werner, C., Schelhaas, M.J., D. R. Cameron, J. Kros, Schelhaas, M. J., Kiese, R., Reuter, Hannes Isaak, R. Kiese, Kros, Johannes, Van Oijen, M., Vries, W. de, Oijen, M. Van, J. Yeluripati, A. Leip, Heuvelink, G. B.M., De Vries, W., Heuvelink, Gerard B.M., Kiese, Ralf, D. R. Cameron, Grote, R., M. J. Schelhaas, Yeluripati, J., Cameron, D. R., Reuter, H.I., Reinds, G. J., Heuvelink, Gerardus Bernardus Maria, G. B. M. Heuvelink, Schelhaas, Mart Jan, Leip, Adrian   +60 more
core   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Are old-growth forests still able to accumulate carbon?

Forest@, 2006
A recent paper published in Science (Zhou et al. 2006) reports an unexpectedly high accumulation of carbon in the top 20-cm soil layer in a preserved old-growth forest in southern China during 24 years.
Grassi G
doaj