Results 111 to 120 of about 1,001,282 (315)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Religious pathways to coping with personal death anxiety among older adult British Christians and Chinese Buddhists: afterlife beliefs, psychosocial maturity and regret management

, 2012
Religion was proposed to account for the relatively low personal death anxiety found among older adults. This dissertation sought to examine the influence of religious afterlife beliefs, religiously enhanced psychosocial maturity and religious management
Hui, Victoria Ka-Ying
core  

The internet, E-commerce and older people: an actor-network approach to researching reasons for adoption and use

, 2003
Many older people are discovering the Internet, and some are also making good use of electronic commerce and all that goes with it. Others, however, are not adopting these technologies.
Tatnall, Arthur, Lepa, Jerzy
core   +1 more source

The effect of urban–rural resident basic medical insurance on physical health of the rural older adult in China

Frontiers in Public Health
IntroductionUrban–Rural Resident Basic Medical Insurance (URRBMI) is an important system for effectively transferring disease risks to the rural older adult.
Xiaohong Pu, Sichang He, Xi Lin
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Can adult education delay retirement from the labour market? [PDF]

In this paper, we examine whether adult education delays retirement and increases labour force participation among the elderly, a mechanism suggested in the OECD strategy for “active ageing” and the “Lisbon strategy” of the EU.
de Luna, Xavier, Stenberg, Anders, Westerlund, Olle   +2 more
core  

Spatial–temporal evolution and associated factors of older adult care institutions in Shanghai

Frontiers in Public Health
BackgroundShanghai is one of the first Chinese cities to tackle the challenges presented by an aging population. In response, the city has been actively seeking solutions for older adult care within a metropolitan context.
Xingxing Yin, Jinghang Cui, Yifan Wu, Mingxuan Cui, Kun Li, Haoxiang Guo   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Lifelong learning in later life: a handbook on older adult learning

, 2017
This book, first published in 2011, offers a comprehensive and international perspective on the theory and practice associated with lifelong learning as it relates to older learners. Findsen and Formosa have delivered a text that situates the older adult
Mark A Tyler, Tyler, Mark A
core   +1 more source