Results 61 to 70 of about 3,409,145 (305)

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Multimodal and longitudinal characterization of distinct tau and atrophy clusters in Alzheimer’s disease spectrum

Scientific Reports
Neuropathological and neuroimaging studies have identified several (endo-)phenotypes of Alzheimer’s disease (AD), suggesting a substantial heterogeneity in cerebral atrophy and tau spreading patterns. We included in our study a total of 320 participants,
Boris-Stephan Rauchmann, Ersin Ersözlü, Dorothea Luedecke, Nicolai Franzmeier, Robert Perneczky   +4 more
doaj   +1 more source

Structural equation modeling of symptom clusters and health-related quality of life among patients with advanced colorectal cancer receiving chemotherapy in Bangkok, Thailand

Belitung Nursing Journal
Background: Patients with advanced colorectal cancer (CRC) receiving chemotherapy experience multiple symptoms due to both disease progression and complications of treatment. These symptoms affect the physical, psychological, and social aspects of health-
Savitree Suratako, Yaowarat Matchim, Mary Quinn Griffin   +2 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

How are falls and fear of falling associated with objectively measured physical activity in a cohort of community-dwelling older men? [PDF]

, 2014
Falls affect approximately one third of community-dwelling older adults each year and have serious health and social consequences. Fear of falling (FOF) (lack of confidence in maintaining balance during normal activities) affects many older adults ...
Morris, RW, Claudio Sartini, Whincup, PH, S Goya Wannamethee, Morris, Richard W, Kendrick, Denise, Kerse, N, Lucy T Lennon, Ngaire Kerse, Kerse, Ngaire, Kendrick, D, Sartini, Claudio, Lennon, Lucy T, Morris, Richard W., Sartini, C, Trost, Stewart, Wannamethee, SG, Lennon, Lucy T., Jefferis, Barbara J, Richard W Morris, Jefferis, BJ, Barbara J Jefferis, Whincup, Peter H, Ash, S, Iliffe, S, Jefferis, Barbara J., Ash, Sarah, Wannamethee, S Goya, Stewart Trost, Denise Kendrick, Iliffe, Steve, Trost, S, Sarah Ash, Lennon, LT, Steve Iliffe, Peter H Whincup, Whincup, Peter H.   +36 more
core   +2 more sources

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source

Experiences of in-home evaluation of independent living technologies for older adults [PDF]

, 2009
Evaluating home-based independent living technologies for older adults is essential. Whilst older adults are a diverse group with a range of computing experiences, it is likely that many of this user group may have little experience with technology and ...
Bailey, Cathy, Dromey, Ben, Doyle, Julie
core  

Biography-based games for cognitive stimulation of older adults

, 2022
Currently, cognitive stimulation exercises conducted with Mild Cognitive Impairment (MCI)-affected older adults are typically administered by care professionals through exercises, which require a high degree of involvement by professional therapists, and
Manca M., Catricala' B., Santoro C., Paterno' F.   +3 more
core  

The progress in the field of clinical staging for mental disorders within the last decade: an updated systematic review

Frontiers in Psychiatry
IntroductionClinical staging aims to refine psychiatric diagnosis by describing mental disorders on a continuum of disorder progression, with the pragmatic goal of improved treatment planning and outcome prediction.
Sharon L. Clarke, Sharon L. Clarke, Nicole Soons, Arjan C. Videler, Arjan C. Videler, Sebastiaan P. J. van Alphen, Sebastiaan P. J. van Alphen, Henricus Van, Linda Dil, Laurens Pappijn, Sven Corbeij, Beau Broekhof, Beau Broekhof, Andrew M. Chanen, Andrew M. Chanen, Joost Hutsebaut, Joost Hutsebaut   +16 more
doaj   +1 more source