Results 61 to 70 of about 1,235,469 (310)

Recessions and Older Workers [PDF]

With the economy sliding ever deeper into recession, questions arise about how older workers are faring and how their fate relative to younger workers compares to the past. The answer to these questions turns out to be a little complicated.
Alicia H. Munnell, Dan Muldoon, Steven A. Sass   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Old dogs, new tricks: a cognitive-behavioral intervention to boost training self-efficacy

Frontiers in Organizational Psychology
IntroductionThis study evaluates whether a brief cognitive-behavioral intervention focusing on cognitive restructuring of learning-related beliefs can increase employees' self-efficacy for training, reduce learning-related anxiety, and improve learning ...
Christian Stamov Roßnagel
doaj   +1 more source

Older People in the Platform Economy

Frontiers in Sociology, 2019
Since the platform economies have emerged, there are many new ways how people can perform earning activities. These new opportunities concern older people too.
Eva Berde, Eva Berde
doaj   +1 more source

Hard Work? Patterns of Physically Demand Labor Among Older Workers [PDF]

Employment in physically demanding jobs or in jobs with difficult working conditions is a major cause of early labor-market exit among older workers. Raising the retirement age is particularly concerning for near-retirement age workers with such jobs ...
Hye Jin Rho
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Eldre i arbeidslivet – slitenhet og yrkesavgang

Søkelys på Arbeidslivet, 2019
Er eldre yrkesaktive mer slitne enn yngre og er slitenhet en årsak til at mange går av selv om det er flere år igjen til de når aldersgrensen? Dybdeintervjuer med ledere i nitten ulike virksomheter gir inntrykk av at dette er tilfellet.
Katharina Herlofson, Tale Hellevik
doaj   +1 more source

Why Are Older Workers At Greater Risk of Displacement? [PDF]

The conventional wisdom says that older workers are less likely to be displaced than younger workers. While true in the past, the conventional wisdom is no longer true today; the advantage that older workers had has disappeared. This loss of relative job
Alicia H. Munnell, Natalia A. Zhivan, Steven A. Sass   +2 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source