Results 1 to 10 of about 20,552 (186)

Formulation and physical stability test of oleanolic acid cream and gel [PDF]

Pharmaciana, 2018
Plantago major has been empirically used for wound healing. One of its chemical compounds, oleanolic acid, exhibited wound healing activity on hyperglycemic rats.
Kartini , Endang Wahyu Fitriani, Laurances Tansridjata   +2 more
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Oleanolic acid ethanol monosolvate [PDF]

Acta Crystallographica Section E, 2010
Crystals of the title compound (systematic name: 3β-hydroxyolean-12-en-28-oic acid ethanol monosolvate), C30H48O3·C2H5OH, were obtained from unsuccessful co-crystallization trials.
Anna Froelich, Andrzej K. Gzella
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Targeting Oxidative Stress in Carcinogenesis: Oleanolic Acid and Its Molecular Pathways [PDF]

Antioxidants
This narrative review aims to systematize the current knowledge on the dual role of reactive oxygen species and reactive nitrogen species in cancer processes, from their physiological function in redox signaling to their pathological impact in oxidative ...
Andrzej Günther, Maciej Kulawik, Szymon Sip, Przemysław Zalewski, Donata Jarmołowska-Jurczyszyn, Przemysław Stawicki, Barbara Bednarczyk-Cwynar   +6 more
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Study of the Stability and Anti-Inflammatory Activity of Paeonol–Oleanolic Acid Liposomes by Microfluidic Technology [PDF]

Foods
(1) Background: This study used a microfluidic approach to prepare paeonol (PAE) liposomes with oleanolic acid (PAE-ONLs) instead of cholesterol (PAE-CNLs), aiming to reduce cholesterol levels and enhance stability and anti-inflammatory activity.
Xianzheng Ma, Hui Zhang, Jinkai Luan, Mingfa Tian, Xiuxin Zhang, Ammara Sohail, Dong Liang, Jiguo Liu, Fuzhan Tao, Zheng Wang, Daijie Wang   +10 more
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Integrated transcriptome-metabolome analysis reveals oleanolic acid as a central regulator of heat stress adaptation in Rhododendron moulmainense [PDF]

BMC Plant Biology
Background Alpine rhododendron has high ornamental value because of its vibrant color. However, growing them in urban landscapes is challenging, as high temperatures can slow the growth of Rhododendron roots and cause leaf burning.
Sijia Liu, Luwen Zhang, Yuqing Bai, Peng Zhuang, Hongyue Cai, Jingen Peng, Zipeng Cai, Bing Hu, Xin Mao, Lijuan Xie   +9 more
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Facile Synthesis of Oleanolic Acid Monoglycosides and Diglycosides [PDF]

Molecules, 2008
Oleanolic acid and its glycosides are important natural products, possessing various attractive biological activities such as antitumor, antivirus and anti-inflammatory properties.
Mao-Sheng Cheng, Yang Liu, Jiao Liu, Mao-Cai Yan, Yu Sha   +4 more
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Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis [PDF]

Acta Pharmaceutica Sinica B
Src homology 2 domain-containing tyrosine phosphatase 2 (SHP2) is an essential tyrosine phosphatase that is pivotal in regulating various cellular signaling pathways such as cell growth, differentiation, and survival.
Jinbo Hu, Wen Liu, Yi Zou, Chenyang Jiao, Jiazhen Zhu, Qiang Xu, Jianjun Zou, Yang Sun, Wenjie Guo   +8 more
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Oleanolic acid combined with aspirin plays antitumor roles in colorectal cancer via the Akt/NFκB/IκBα/COX2 pathway [PDF]

Cell Death Discovery
Among the common malignancies, colorectal cancer (CRC) is often resistant to chemotherapy because of drug resistance and severe toxicity. Currently, aspirin is one of the most promising CRC chemopreventive drugs, both for primary prevention and for ...
Yulv Zhou, Shengnan Lin, Xinzhu Zhong, Fang Huang, Jinxiang Huang, Luning Xu   +5 more
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Greener approach for the isolation of oleanolic acid from Nepeta leucophylla Benth. Its derivatization and their molecular docking as antibacterial and antiviral agents

Heliyon, 2023
In the present study bioactive methanolic extract along with chloroform and hexane extracts obtained from shade dried leaves of the Himalayan aromatic medicinal plant Nepeta leucophylla Benth.
Ajay Sharma, Deepika Kathuria, Bhaskor Kolita, Apurba Gohain, Ashoke Kumar Das, Garima Bhardwaj, Jesus Simal-Gandara   +6 more
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Identification of Oleanolic Acid as Allosteric Agonist of Integrin αM by Combination of In Silico Modeling and In Vitro Analysis

Frontiers in Pharmacology, 2021
Oleanolic acid is a widely distributed natural product, which possesses promising antitumor, antiviral, antihyperlipidemic, and anti-inflammatory activities. A heterodimeric complex formed by integrin αM (CD11b) and integrin β2 (CD18) is highly expressed
Lu Jin, Lu Jin, Xiaoyu Han, Xinlei Zhang, Zhimin Zhao, Judith Ulrich, Tatiana Syrovets, Thomas Simmet   +7 more
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