Results 101 to 110 of about 20,571 (205)

Ursolic and Oleanolic Acids Induce Mitophagy in A549 Human Lung Cancer Cells

Molecules, 2019
Ursolic and oleanolic acids are natural isomeric triterpenes known for their anticancer activity. Here, we investigated the effect of triterpenes on the viability of A549 human lung cancer cells and the role of autophagy in their activity.
Nayeli Shantal Castrejón-Jiménez, Kahiry Leyva-Paredes, Shantal Lizbeth Baltierra-Uribe, Juan Castillo-Cruz, Marcia Campillo-Navarro, Alma Delia Hernández-Pérez, Alexandra Berenice Luna-Angulo, Rommel Chacón-Salinas, Ramón Mauricio Coral-Vázquez, Iris Estrada-García, Luvia Enid Sánchez-Torres, Carlos Torres-Torres, Blanca Estela García-Pérez   +12 more
doaj   +1 more source

Studies on Cytotoxic Constituents from the Leaves of Elaeagnus oldhamii Maxim. in Non-Small Cell Lung Cancer A549 Cells

Molecules, 2014
Elaeagnus oldhamii Maxim. is a commonly used traditional herbal medicine. In Taiwan the leaves of E. oldhamii Maxim. are mainly used for treating lung disorders. Twenty five compounds were isolated from the leaves of E. oldhamii Maxim.
Chi-Ren Liao, Yueh-Hsiung Kuo, Yu-Ling Ho, Ching-Ying Wang, Chang -Syun Yang, Cheng-Wen Lin, Yuan-Shiun Chang   +6 more
doaj   +1 more source

A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules [PDF]

, 2017
Plants are an excellent source of drug leads. However availability is limited by access to source species, low abundance and recalcitrance to chemical synthesis.
Alain Goossens, Alberti, Anarat-Cappillino, Andersen-Ranberg, Anne Osbourn, Aymeric Leveau, Bastiaan Brouwer, Biazzi, Boutanaev, Brown, Carelli, DeLoache, Fukushima, Fukushima, Galanie, Geisler, Geu-Flores, Harvey, Hill, Itkin, James Reed, Karel Miettinen, Kemen, Khakimov, Kwok, Li, Liby, Maria A. O’Connell, Marsian, Medema, Michael J. Stephenson, Miettinen, Miettinen, Moses, Moses, Moses, Moses, Moses, Nielsen, Owen, Paddon, Patron, Paul Brett, Polturak, Qu, Rajniak, Rebecca J.M. Goss, Sainsbury, Sainsbury, Salmon, Seki, Seki, Shang, Shibuya, Thimmappa, Wang, Yasumoto, Zhang   +57 more
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Hybrid Compounds Strategy in the Synthesis of Oleanolic Acid Skeleton-NSAID Derivatives

Molecules, 2016
The current study focuses on the synthesis of several hybrid individuals combining a natural oleanolic acid skeleton and synthetic nonsteroidal anti-inflammatory drug moieties (NSAIDs).
Anna Pawełczyk, Dorota Olender, Katarzyna Sowa-Kasprzak, Lucjusz Zaprutko   +3 more
doaj   +1 more source

HCV Protease Inhibitory, Cytotoxic and Apoptosis-Inducing Effects of Oleanolic Acid Derivatives

Journal of Pharmacy & Pharmaceutical Sciences, 2009
Purpose: To evaluate oleanolic acid derivatives on liver disease related bioactivities, 29 oleanolic acid derivatives of several series were tested for their inhibitory activity on hepatitis C viral protease and for their cytotoxic effects on Hep G2 ...
Chao-Mei Ma, Xiu-Hong Wu, Masao Hattori, Xi-Jun Wang, Yoshihiro Kano   +4 more
doaj   +1 more source

The effect of elicitors on oleanolic acid accumulation and expression of triterpenoid synthesis genes in Gentiana straminea

Biologia Plantarum, 2013
Gentiana straminea is native to the Qinghai-Tibet plateau, where it is exposed to extremes of cold and strong UV-B radiation. Here we showed that low temperature, but not UV-B radiation, affected the accumulation of the triterpenoid oleanolic acid ...
Z. -J. Zhao, Y. -G. Song, Y. -L. Liu, M. Qiao, X. -L. Zhai, F. -N. Xiang   +5 more
doaj   +1 more source

Detection and Quantification of Glucuronidation of Ursolic Acid (UA) in Human Liver Microsomes (HLMs). [PDF]

, 2018
https://scholarscompass.vcu.edu/uresposters/1270/thumbnail ...
Gerk, Philip M., Tolliboeva, Kamola
core   +1 more source

ANTIOXIDANT ACTIVITY OF THE MEDICINAL PLANT LANTANA CAMARA L.

FUUAST Journal of Biology, 2018
The propose of this study was to estimate the antioxidant activity of methanolic extract, its fractions and three pure compounds lantadene A (1), oleanolic acid (2) and lantanilic acid (3) of the aerial parts of the Lantana camara Linn.
ANJUM AYUB, SAIMA TAUSEEF, SYED TAHIR ALI   +2 more
doaj  

Steroidal and triterpenoidal glucosides from Passiflora alata

Journal of the Brazilian Chemical Society, 2001
Five glycosides were isolated from leaves of P. alata. The structures 1-5 were obtained through extensive spectral analyses as 3-O-beta-D-glucopyranosyl-stigmasterol (1), 3-O-beta-D-glucopyranosyl-oleanolic acid (2), 3-O-beta-D-glucopyranosyl-(1->3)-beta-
Reginatto Flávio H., Kauffmann Carla, Schripsema Jan, Guillaume Dominique, Gosmann Grace, Schenkel Eloir P.   +5 more
doaj  

Aceite de orujo de oliva comestible concentrado en ácidos triterpénicos, procedimiento de refinación física utilizado para su obtención y recuperación de los componentes funcionales presentes en el aceite crudo [PDF]

, 2008
Aceite de orujo de oliva comestible concentrado en ácidos triterpénicos, procedimiento de refinación física utilizado para su obtención y recuperación de los componentes funcionales presentes en el aceite crudo.
Dobarganes, M. Carmen, Ruiz Méndez, Mª Victoria, Sánchez Moral, Pedro   +2 more
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