Results 131 to 140 of about 339,145 (335)

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH‐1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode‐derived cells in the brain

Developmental Dynamics, EarlyView.
Abstract The olfactory placode (OP) generates a broad array of chemosensory neurons in the nasal region, including olfactory sensory neurons, vomeronasal sensory neurons, neurons of the septal organ, and Grueneberg ganglion. During invagination, the OP also generates migratory neuronal populations, including gonadotropin‐releasing hormone‐1 (GnRH‐1 ...
Enrico Amato Jr., Mia V. Call, Noah M. LeFever, Mya Aviles‐Carlos, Nikki M. Dolphin, Paolo E. Forni   +5 more
wiley   +1 more source

Dissecting Local Circuits: Parvalbumin Interneurons Underlie Broad Feedback Control of Olfactory Bulb Output

Neuron, 2013
Summary In the mouse olfactory bulb, information from sensory neurons is extensively processed by local interneurons before being transmitted to the olfactory cortex by mitral and tufted (M/T) cells.
Kazunari Miyamichi, Yael Shlomai-Fuchs, Marvin L. Shu, Brandon Weissbourd, Liqun Luo, A. Mizrahi   +5 more
semanticscholar   +1 more source

Zebrafish ventral gastrula fate map reveals neural crest progenitor domain

Developmental Dynamics, EarlyView.
Abstract Background Fate maps relate progenitor cell positions to later fates and locations of their progeny, revealing early embryonic organization. Previous zebrafish fate maps identified the origin of germ layers and derivative cell fates, but ventral gastrula progenitor domains were not fully resolved. In particular, the neural crest, a multipotent
Elaine E. Kushkowski, Victoria E. Prince
wiley   +1 more source

P86 | THE EFFECTS OF NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITION ON THE EXPRESSION OF BRAIN DERIVED NEUROTROPHIC FACTOR IN THE OLFACTORY BULB ORGANOTYPIC SLICE CULTURES

European Journal of Histochemistry
Olfactory bulb (OB) exhibits high levels of nicotinic acetylcholine receptor (nAChR) expression and receive strong cholinergic input from the basal forebrain. Acetylcholine is important modulator in olfactory related memory.
doaj   +1 more source

Parvalbumin-expressing interneurons linearly control olfactory bulb output

Neuron, 2013
SUMMARY In the olfactory bulb, odor representations by principal mitral cells are modulated by local inhibitory circuits. While dendrodendritic synapses between mitral and granule cells are typically thought to be a major source of this modulation, the ...
Hiroyuki K. Kato, S. Gillet, Andrew J. Peters, J. Isaacson, T. Komiyama   +4 more
semanticscholar   +1 more source

Chemo- and Thermosensory Responsiveness of Grueneberg Ganglion Neurons Relies on Cyclic Guanosine Monophosphate Signaling Elements [PDF]

, 2011
Neurons of the Grueneberg ganglion (GG) in the anterior nasal region of mouse pups respond to cool temperatures and to a small set of odorants. While the thermosensory reactivity appears to be mediated by elements of a cyclic guanosine monophosphate ...
Biel, Martin, Yang, Ruey-Bing, Mamasuew, Katharina, Breer, Heinz, Kretzschmann, Verena, Fleischer, Joerg, Hofmann, Nina   +6 more
core   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]

, 2004
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Guimond, S, Bouloux, PM, Turnbull, Jeremy, Turnbull, J, Hu, Youli, Kim, SH, Kim, Soo-Hyun, Schofield, Jonathan, Winyard, P, Winyard, Paul, Vannelli, GB, Bouloux, Pierre-Marc, Gonzalez-Martinez, D, Hu, YL, Schofield, J, Vannelli, Gabriella Barbara, González-Martínez, David, Guimond, Scott   +17 more
core   +1 more source

Evaluation of the Toxicity, Morphological and Behavioural Effects of Pelargonium graveolens Essential Oil in Artemia franciscana, Along With Its Antimicrobial Activity

Flavour and Fragrance Journal, EarlyView.
Essential oil of Pelargonium graveolens exhibited potent antimicrobial activity against bacterial and fungal pathogens, while higher concentrations induced mortality and altered swimming behaviour in Artemia franciscana. These findings highlight its therapeutic potential and underscore the importance of defining safe concentration ranges to support ...
Silvana de Oliveira, Caio Alexandre de Freitas Schatzer, Tiago Schena, Fernanda Dias da Silva, Elizabeth Teodorov   +4 more
wiley   +1 more source