Results 171 to 180 of about 250,076 (386)

A Biomarker‐Based Classification of Corticobasal Syndrome

open access: yesMovement Disorders, EarlyView.
Abstract Background Corticobasal syndrome (CBS) is a clinically defined syndrome with progressive movement and cortical dysfunction, caused by various underlying pathologies, most commonly tau‐predominant pathologies such as progressive supranuclear palsy and corticobasal degeneration, or Alzheimer's disease (AD).
Carla Palleis   +13 more
wiley   +1 more source

Perampanel Blocks Transsynaptic α‐Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Transsynaptic α‐synuclein propagation plays a crucial role in the progression of Lewy body disease. We previously demonstrated that an α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antagonist, perampanel, blocks neuronal uptake of α‐synuclein preformed fibrils (PFFs) in an activity‐dependent manner.
Jun Ueda   +9 more
wiley   +1 more source

Using context to make gas classifiers robust to sensor drift

open access: yes, 2020
The interaction of a gas particle with a metal-oxide based gas sensor changes the sensor irreversibly. The compounded changes, referred to as sensor drift, are unstable, but adaptive algorithms can sustain the accuracy of odor sensor systems.
Devaraj, A.   +2 more
core  

Design of Experiments (DoE)‐Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose‐to‐Brain Delivery

open access: yesSmall, EarlyView.
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad   +11 more
wiley   +1 more source

Illicit Drug‐Derived Volatile Organic Compounds as Markers for Application in Noncontact Detection Technology

open access: yesThe Chemical Record, EarlyView.
This review highlights the characteristic odor markers of illicit drugs, emphasizing volatile markers from both natural and synthetic sources, and explores the shift from canine‐based detection to emerging noncontact sensing technologies. Illicit drug use remains a global concern, requiring effective detection methods to counter evolving concealment ...
Minwoo Kim   +4 more
wiley   +1 more source

SARS-CoV-2-Related Olfactory Dysfunction: Autopsy Findings, Histopathology, and Evaluation of Viral RNA and ACE2 Expression in Olfactory Bulbs

open access: yesBiomedicines
Background: The COVID-19 pandemic has been a health emergency with a significant impact on the world due to its high infectiousness. The disease, primarily identified in the lower respiratory tract, develops with numerous clinical symptoms affecting ...
Marco Dell’Aquila   +11 more
doaj   +1 more source

Chemical dehydration‐induced ultrafast clearing method for human tissues

open access: yesVIEW, EarlyView.
Three‐dimensional (3D) histology of human tissue through clearing has been hampered by the lengthy and intricate procedure. Here, a rapid and straightforward clearing protocol termed single‐step dehydration solvent‐based clearing (SSD) is proposed via a chemical dehydration strategy.
Yi Dai   +16 more
wiley   +1 more source

Nurr1 blocks the mitogenic effect of FGF‐2 and EGF, inducing olfactory bulb neural stem cells to adopt dopaminergic and dopaminergic‐GABAergic neuronal phenotypes

open access: green, 2014
Eva Vergaño‐Vera   +9 more
openalex   +2 more sources

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