Results 191 to 200 of about 46,881 (221)

Functional but Not Structural Brain Changes After Olfactory Training in Women With COVID‐19‐Associated Olfactory Dysfunction

The Laryngoscope, Volume 135, Issue 6, Page 2089-2096, June 2025.
Olfactory training (OT) significantly improves olfactory function in patients with post‐viral olfactory dysfunction compared to healthy controls. OT was associated with enhanced functional activation in the orbitofrontal cortex and parahippocampal region.
Zetian Li, Julia Gebler, Akshita Joshi, Xinni Xu, Divesh Thaploo, Antje Hähner, Vittoria Avaro, Federico Calegari, Thomas Hummel   +8 more
wiley   +1 more source

The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases

MedComm, Volume 6, Issue 6, June 2025.
Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu, Shiyuan Huang, Li Peng, Li Yang, Guosong Zhang, Tao Liu, Fang Yan, Xi Peng   +7 more
wiley   +1 more source

Mitochondrial Transplantation: A Novel Therapeutic Approach for Treating Diseases

MedComm, Volume 6, Issue 6, June 2025.
This article describes the roles of mitochondria in health and disease and reviews the effects of mitochondrial transplantation in disease, including restoring ATP production, attenuating oxidative stress, modulating inflammatory responses, reducing apoptosis, promoting cell repair, and exhibiting antitumor properties.
Xinglu Miao, Pei Jiang, Zhaoping Wang, Weihua Kong, Lei Feng   +4 more
wiley   +1 more source

Mechanisms governing dendritic gamma -aminobutyric acid (GABA) release in the rat olfactory bulb

, 2000
Jeffry S. Isaacson
openalex   +2 more sources

CXCL10highTNFαhighKi67+ Microglia Recruit and Activate CD8+ T Cells in the Brainstem During Experimental Cerebral Malaria

CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
Microglia exhibit distinct transcriptional and morphological heterogeneity in experimental cerebral malaria (ECM) compared to physiological microglia. A unique subtype of ECM‐associated microglia, characterized by CXCL10highTNFαhighKi67+, mediates the recruitment and sustained activation of CD8+ T cells through ongoing interactions, exacerbating ...
Yi Wang, Jiao Liang, Chao Yang, Jun Wang, Qinghao Zhu, Guodong Tong, Tong Li, Ganze Li, Yuxiao Huang, Yimin Yang, Jie Ren, Yinghui Li, Yan Shen, Ya Zhao   +13 more
wiley   +1 more source

Microglial activation in the developing rat olfactory bulb

, 2000
Brian Fiske, Peter C. Brunjes
openalex   +1 more source

A Mutation in the Transmembrane Domain of Adenylate Cyclase 3 Impairs Enzymatic Function to Cause Sex‐Specific Depression‐ and Anxiety‐Like Behaviors and Food Seeking in a Rat Model

Genes, Brain and Behavior, Volume 24, Issue 3, June 2025.
Rats with a transmembrane domain mutation in Adcy3 have increased adiposity and increased negative emotion‐like behaviors, and male mutants show increased food seeking. Mechanistically, this mutation causes decreased cAMP production. Obesity and depression may therefore be linked genetically through Adcy3, and the ADCY3 transmembrane domain is critical
Mackenzie K. Fitzpatrick, Christina Dyson, Angela Beeson, Leighelle Adrian, Glen Marrs, Michael Grzybowski, Jason Klotz, Aron M. Geurts, Rong Chen, Jeffrey L. Weiner, Leah C. Solberg Woods   +10 more
wiley   +1 more source

Differing Genetics of Saline and Cocaine Self‐Administration in the Hybrid Mouse Diversity Panel

Genes, Brain and Behavior, Volume 24, Issue 3, June 2025.
Longitudinal genome scans for saline intravenous self‐administration over 10 days in the hybrid mouse diversity panel. ABSTRACT To identify genes that regulate the response to the potentially addictive drug cocaine, we performed a control experiment using genome‐wide association studies (GWASs) and RNA‐Seq of a panel of inbred and recombinant inbred ...
Arshad H. Khan, Jared R. Bagley, Nathan LaPierre, Carlos Gonzalez‐Figueroa, Tadeo C. Spencer, Mudra Choudhury, Xinshu Xiao, Eleazar Eskin, James D. Jentsch, Desmond J. Smith   +9 more
wiley   +1 more source

Rethinking Sensory Information Processing: The Essential Role of Astrocytes

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
In this review, we discuss recent advances highlighting the emerging roles of astrocytes in sensory information processing. We review how astrocytes are anatomically integrated within distinct sensory systems, how they are activated by specific external stimuli, and how their modulation influences the output of sensory neurons to shape behavioral ...
Juliana M. Rosa, Juan Aguilar
wiley   +1 more source

Evaluation of the endocranial anatomy of the early Paleogene north African gavialoid crocodylian Argochampsa krebsi and evolutionary implications for adaptation to salinity tolerance in marine crocodyliforms

Journal of Anatomy, Volume 246, Issue 6, Page 974-986, June 2025.
Abstract Argochampsa krebsi is a gavialoid crocodylian from the early Paleogene of North Africa. Based on its recovered phylogenetic relationship with South American species, it has been inferred to have been capable of transoceanic dispersal, but potential anatomical correlates for a marine lifestyle have yet to be identified.
Carly C. Pligersdorffer, Paul M. J. Burke, Philip D. Mannion   +2 more
wiley   +1 more source