Results 261 to 270 of about 115,804 (336)

EFFECTS OF PENTOBARBITONE, KETAMINE AND LIGNOCAINE ON SYNAPTIC TRANSMISSION IN THE RAT OLFACTORY CORTEX IN VITRO

, 1989
Makoto Iwasaki
openalex   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

The impact of nicotine on the olfactory memory and its relationship with TRPA1. [PDF]

iScience
Mizobata K, Sakatani H, Kono M, Saika S, Akaike A, Hotomi M.   +5 more
europepmc   +1 more source

Treg Cells Modulate Neuroinflammation and Behavioral Deficits in Autism: Evidence From MR‐Based Genetic Analyses and Experimental Models

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 2, Page 127-143, March 2026.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD.
Zuqing Nie, Xinyi Xu, Junhao Chen, Huiling Chen, Meng Li, Yang Zhang, Zhiwei Li, Chen Shen, Jie Wen, Xia Cao   +9 more
wiley   +1 more source

Altered locus coeruleus links to atrophy and hypometabolism in individuals with high Alzheimer's disease biomarkers

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION The locus coeruleus (LC), the first region to contain tau pathology in Alzheimer's disease (AD), releases norepinephrine, which has a neuroprotective role. We examined whether LC integrity relates to whole‐brain integrity and how AD biomarkers may moderate this relationship.
Emilie Foyard, Tao Blanchard, Brigitte Landeau, Léa Chauveau, Mikaël Naveau, Géraldine Poisnel, Eric Bui, Gaël Chetelat, Robin de Flores, for the Medit‐Ageing Research Group   +9 more
wiley   +1 more source

Altered dynamic functional connectivity of orbitofrontal cortex underlies olfactory and cognitive impairment in late-life depression. [PDF]

Psychoradiology
Chen B, Liang S, Su T, Zheng Y, He W, Zhou H, Wang Q, Yang M, Lin G, Xu D, Chen Y, Li J, Liu Q, Yao K, Wu Z, Zhang M, Hou L, Zhang Y, Zhong X, Ning Y.   +19 more
europepmc   +1 more source

Sex and life experience shape locus coeruleus pretangle tau pathology

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Alzheimer's disease features early a pathology in the locus coeruleus (LC), yet how sex and life experience shape LC vulnerability remains poorly understood. METHODS We expressed pseudophosphorylated human tau (htauE14) in LC neurons of TH‐Cre rats and exposed both sexes to early‐ or late‐life enrichment or stress.
Zia Hasan, Sarah E. Torraville, Tamunotonye Omoluabi, Aida Maziar, Onyedikachi N. Belolise, Lauren A. MacGowan, Cassandra M. Flynn, Camila Reinhardt, Susan G. Walling, Touati Benoukraf, Qi Yuan   +10 more
wiley   +1 more source

Olfactory Dysfunction and Cognitive Deterioration in Long COVID: Pathomechanisms and Clinical Implications in Development of Alzheimer's Disease. [PDF]

Cells
Stigliano E, Tocci A, Florio R, Arena V, Amadoro G.   +4 more
europepmc   +1 more source

Anatomical Progression of Neuropathology in FTLD‐TDP Type C and Linkage to Annexin A11

Annals of Neurology, Volume 99, Issue 3, Page 639-655, March 2026.
Objective Frontotemporal lobar degenerations (FTLD)‐TDP type C (TDP‐C) is distinguished from other FTLD‐TDP subtypes by 3 unique features: (1) invariable onset in the anterior temporal lobe (ATL), (2) phosphorylated TDP‐43 (pTDP) neurites in cortex, and (3) colocalization of all pTDP deposits with annexin A11 (ANXA11).
Allegra Kawles, Caroline Nelson, Ivan Ayala, Elena Barbieri, Rudolph Castellani, Changiz Geula, Tamar Gefen, M. Marsel Mesulam   +7 more
wiley   +1 more source