Results 1 to 10 of about 357,031 (196)

Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR [PDF]

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Olfactory dysfunction can be an early sign of Alzheimer's disease (AD). We used tau positron emission tomography‐magnetic resonance (PET‐MR) to analyze a key region of the olfactory circuit, the piriform cortex, in comparison to the adjacent
Hossein Moein Taghavi, Mahta Karimpoor, Eric K. vanStaalduinen, Christina B. Young, Marios Georgiadis, Samantha Leventis, Mackenzie Carlson, America Romero, Alexandra Trelle, Hillary Vossler, Maya Yutsis, Jarrett Rosenberg, Guido A. Davidzon, Greg Zaharchuk, Kathleen Poston, Anthony D. Wagner, Victor W. Henderson, Elizabeth Mormino, Michael Zeineh   +18 more
doaj   +3 more sources

The role of the piriform cortex in temporal lobe epilepsy: A current literature review [PDF]

Frontiers in Neurology, 2022
Temporal lobe epilepsy is the most common form of focal epilepsy and can have various detrimental consequences within many neurologic domains. Recent evidence suggests that the piriform cortex may also be implicated in seizure physiology.
Keanu Chee, Ashkaun Razmara, Aaron S. Geller, William B. Harris, Diego Restrepo, John A. Thompson, Daniel R. Kramer   +6 more
doaj   +2 more sources

Dynamic recovery of piriform cortex function and its impact on cognitive processing speed following mild COVID-19 [PDF]

BMC Neurology
Background Although the neurological sequelae of severe COVID-19 are increasingly recognized, the long-term neural impact of uncomplicated mild SARS-CoV-2 infection remains insufficiently characterized.
Hyeonseok Jeong, Youngeun Shim, Yoonji Joo, Yejin Kim, Chaewon Suh, Yunjung Jin, Harin Song, In Kyoon Lyoo, Sujung Yoon   +8 more
doaj   +2 more sources

Integrative analysis of single-cell multi-omics reveals heterogeneity in piriform cortex principal neurons and their selective vulnerability in Alzheimer's disease. [PDF]

Clin Transl Med
Integrative single‐cell multi‐omics analysis reveals molecular heterogeneity among piriform cortex principal neurons and identifies Reln+ superficial‐layer neurons as a selectively vulnerable population in Alzheimer's disease. Cross‐region comparison with entorhinal cortex layer II neurons reveals a shared Gpc5‐high/Sort1‐low vulnerability‐associated ...
Meng J, Zhang M, Chen Y, Han M, Cheng N, Cao R, He Q, Zhao Y, Yuan L, Zhang G.   +9 more
europepmc   +2 more sources

Interictal blood–brain barrier dysfunction in piriform cortex of people with epilepsy [PDF]

Annals of Clinical and Translational Neurology
Objective The piriform cortex is considered to be highly epileptogenic. Its resection during epilepsy surgery is a predictor for postoperative seizure freedom in temporal lobe epilepsy. Epilepsy is associated with a dysfunction of the blood–brain barrier.
Freya Schulte, Johannes T. Reiter, Tobias Bauer, Julia Taube, Felix Bitzer, Juri‐Alexander Witt, Rory Piper, Anoja Thanabalasingam, Randi vonWrede, Attila Racz, Tobias Baumgartner, Valeri Borger, Louisa Specht‐Riemenschneider, Hartmut Vatter, Elke Hattingen, Ralf Deichmann, Christoph Helmstaedter, Alexander Radbruch, Alon Friedman, Rainer Surges, Theodor Rüber   +20 more
doaj   +2 more sources

LRP4 is required for the olfactory association task in the piriform cortex [PDF]

Cell & Bioscience, 2022
Background Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, fear regulation, as well as long ...
Min Yan, Mingtao Xiong, Yongqiang Wu, Dong Lin, Peng Chen, Jiang Chen, Ziyang Liu, Hang Zhang, Dongyan Ren, Erkang Fei, Xinsheng Lai, Suqi Zou, Shunqi Wang   +12 more
doaj   +2 more sources

Seizure Freedom Despite Piriform Cortex Sparing: Structural Connectivity Remodeling After SEEG-Guided Mesial Temporal RFTC. [PDF]

Eur J Neurol
ABSTRACT Objective To investigate whether selective radiofrequency thermocoagulation (RFTC) targeting mesiotemporal structures, while sparing the piriform cortex (PC), can achieve seizure freedom in drug‐resistant mesial temporal lobe epilepsy (MTLE), and to assess whether said seizure freedom is associated with an indirect disconnection of the PC ...
Jean S, Donkor PE, Wei X, Dai Y, Gong J, Xiao Q, Chen W, Liu W, Fang X, Song S.   +9 more
europepmc   +2 more sources

Doublecortin-immunoreactive neurons in the piriform cortex are sensitive to the long lasting effects of early life stress [PDF]

Frontiers in Neuroscience
The olfactory system is a niche of continuous structural plasticity, holding postnatal proliferative neurogenesis in the olfactory bulbs and a population of immature neurons in the piriform cortex.
María Abellán-Álvaro, Anna Teruel-Sanchis, Maria Francisca Madeira, Maria Francisca Madeira, Maria Francisca Madeira, Enrique Lanuza, Mónica Santos, Mónica Santos, Carmen Agustín-Pavón   +8 more
doaj   +2 more sources

Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top–Down Circuit [PDF]

Advanced Science
Social novelty is indispensable for a wide range of social behaviors. The medial prefrontal cortex (mPFC), along with other social information hubs, composes the foundational circuitry of social novelty.
Jingwei Zhou, Zhaoyang Yin, Zhiyun Chen, Hanyu Fu, Qun Li, Shan Li, Ying Zhang, Xianzhi Zhang, Dewei Tang, Anan Li, Dejuan Wang   +10 more
doaj   +2 more sources

Cell-Type-Specific Whole-Brain Direct Inputs to the Anterior and Posterior Piriform Cortex

Frontiers in Neural Circuits, 2020
The piriform cortex (PC) is a key brain area involved in both processing and coding of olfactory information. It is implicated in various brain disorders, such as epilepsy, Alzheimer’s disease, and autism.
Rafi Haddad, Fuqiang Xu, Anne Manyande   +2 more
exaly   +3 more sources