Results 51 to 60 of about 92,033 (290)

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Olfactory mucosa steroid injection in treatment of post-COVID-19 olfactory dysfunction: a randomized control trial

The Egyptian Journal of Otolaryngology, 2023
Background Olfactory dysfunction can be a troublesome condition affecting the quality of life of the patient. Post-viral olfactory dysfunction is the most common cause attributing to up to 40% of anosmia.
Hisham Lasheen, Mohamed Aly Abou-Zeid
doaj   +1 more source

The Impact of Olfactory Disorders in the United Kingdom [PDF]

, 2014
Olfactory disorders are believed to affect 5% of the general population and have been shown to bear significant psychosocial consequences to sufferers. Although more common than blindness and profound deafness in the United Kingdom, the impact of these ...
Aschenbrenner, Blomqvist, Bramerson, Br  merson, C. M. Philpott, Chalke, Croy, D. Boak, Damm, Deems, Ferris, Frasnelli, Hastan, Haxel, Hummel, Landis, Landis, McNeill, Miwa, Murphy, Nordin, Santos, Shu, Singleton, Temmel, Toller, Vennemann, Wysocki   +27 more
core   +1 more source

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao, Zhuoma Danzhen, Yao Li, Junyu Zhu, Lan Chu, Zhang Yang   +5 more
wiley   +1 more source

Factors that modulate olfactory dysfunction

Neural Regeneration Research, 2018
The olfactory system is one of a few areas in the nervous system which is capable of regeneration throughout the life. Olfactory sensory neurons reside in the nasal cavity are continuously replenished with new neurons arising from stem cells.
Kate Beecher, James A St John, Fatemeh Chehrehasa   +2 more
doaj   +1 more source

Nuclear imaging with radiolabeled odor molecules in patients with olfactory disorder [PDF]

, 2012
Smell loss originates from peripheral disorders, like intranasal obstruction and olfactory cell injury, as well as central pathway diseases. Information derived from electrophysiological and psychophysical tests are useful for identifying loss of ...
ASSADI, majid, EFTEKHARI, m, NABIPOUR, iraj, NEMATI, reza, SALIMIPOUR, hooman, ZAKANI, A   +5 more
core  

A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration [PDF]

, 2012
Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of ...
Bhattacharya, Martha R.C., DiAntonio, Aaron, Ebstein, Sarah Y, Gerdts, Josiah, Milbrandt, Jeffrey, Naylor, Sarah A, Royse, Emily X, Sasaki, Yo   +7 more
core   +2 more sources

Moyamoya Disease and the Risk of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by the progressive narrowing of arteries at the base of the brain, forming abnormal collateral vascular networks. While vascular parkinsonism is noted in MMD, its link to Parkinson's disease (PD) has not been explored.
Dallah Yoo, Jeong‐Yong Shin, Rugyeom Lee, Jiwon Cheon, Ji Hun Kim, Doeun Kim, Jae‐Kyung Won, In‐Hwan Oh, Yunjong Lee, Tae‐Beom Ahn   +9 more
wiley   +1 more source

Correlation Between Coronavirus Disease 2019 and Olfactory Dysfunction

Frontiers in Public Health, 2022
A great number of patients with Coronavirus Disease 2019 (COVID-19) experience olfactory dysfunction, typically of a short duration and with a high incidence rate, during the early stages of infection with severe acute respiratory syndrome coronavirus 2 (
Yufeng Mao, Bin Ye, Cui Fan, Jichang Wu, Beilei Wang, Yilin Shen, Zhihong Shi, Mingliang Xiang   +7 more
doaj   +1 more source

Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21‐Year Period

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations. Postmortem studies have variably, but not always, shown reduced Purkinje cell counts in essential tremor compared to controls.
Chloë A. Kerridge, Roberto S. Hernandez, Nora C. Hernandez, Phyllis L. Faust, Elan D. Louis   +4 more
wiley   +1 more source