Results 101 to 110 of about 7,510,662 (182)

Revisiting olfactory receptors as putative drivers of cancer [version 1; referees: 2 approved]

Wellcome Open Research, 2017
BACKGROUND: Olfactory receptors (ORs) recognize odorant molecules and activate a signal transduction pathway that ultimately leads to the perception of smell.
Marco Ranzani, Vivek Iyer, Ximena Ibarra-Soria, Martin Del Castillo Velasco-Herrera, Mathew Garnett, Darren Logan, David J. Adams   +6 more
doaj   +1 more source

Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly

Science, 2017
Pattern formation in the brain Neurons in the developing brain cooperate to build circuits. Mountoufaris et al. found that ∼50 variable protocadherin genes support a combinatorial identity code that allows millions of olfactory neuron axons to sort into ∼
George Mountoufaris, Weisheng V. Chen, Y. Hirabayashi, S. O’Keeffe, Maxime Chevée, Chiamaka L. Nwakeze, F. Polleux, T. Maniatis   +7 more
semanticscholar   +1 more source

MouSensor: A Versatile Genetic Platform to Create Super Sniffer Mice for Studying Human Odor Coding

Cell Reports, 2016
Typically, ∼0.1% of the total number of olfactory sensory neurons (OSNs) in the main olfactory epithelium express the same odorant receptor (OR) in a singular fashion and their axons coalesce into homotypic glomeruli in the olfactory bulb.
Charlotte D’Hulst, Raena B. Mina, Zachary Gershon, Sophie Jamet, Antonio Cerullo, Delia Tomoiaga, Li Bai, Leonardo Belluscio, Matthew E. Rogers, Yevgeniy Sirotin, Paul Feinstein   +10 more
doaj   +1 more source

Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons

bioRxiv, 2017
The monogenic and monoallelic expression of only one out of > 1000 olfactory receptor (ORs) genes requires the formation of large heterochromatic chromatin domains that sequester the OR gene clusters.
K. Monahan, I. Schieren, J. Cheung, A. Mumbey-Wafula, E. Monuki, S. Lomvardas   +5 more
semanticscholar   +1 more source

Time-course study of genetic changes in periodontal ligament regeneration after tooth replantation in a mouse model

Scientific Reports
This research focused on analyzing gene expression changes in the periodontal ligament (PDL) after tooth re-plantation to identify key genes and pathways involved in healing and regeneration.
Jun Ohshima, Shotaro Abe, Masayoshi Morita, Nobutake Tanaka, Masaya Yamaguchi, Mikako Hayashi   +5 more
doaj   +1 more source

Convergent reduction of olfactory genes and olfactory bulb size in mammalian species at altitude

Current Biology
The invasion of specialized ecological niches can cause drastic changes to selection regimes, resulting in genomic and phenotypic transformation.1 High-altitude habitats offer an excellent opportunity to investigate the genetic basis of local adaptation,2,3 as the repeated specialization of multiple lineages for high altitude has produced striking ...
Allie M. Graham, Elysia Saputra, Bogdan Kirilenko, Jason S. Presnell, Arianna Harrington, Chad Huff, Michael Hiller, Nathan Clark   +7 more
openaire   +3 more sources

The expansion and loss of specific olfactory genes in relatives of parasitic lice, the stored-product psocids (Psocodea: Liposcelididae)

BMC Genomics
Background Booklice, belonging to the genus Liposcelis (Psocodea: Liposcelididae), commonly known as psocids, infest a wide range of stored products and are implicated in the transmission of harmful microorganisms such as fungi and bacteria.
Jun Sun, Jian Wu, Sheng-Yuan Sun, Zhi-Dong Chen, Guy Smagghe, Jin-Jun Wang, Dan-Dan Wei   +6 more
doaj   +1 more source

Comparative analysis of AAV serotypes for transduction of olfactory sensory neurons

Frontiers in Neuroscience
Olfactory sensory neurons within the nasal epithelium detect volatile odorants and relay odor information to the central nervous system. Unlike other sensory inputs, olfactory sensory neurons interface with the external environment and project their ...
Benjamin D. W. Belfort, Benjamin D. W. Belfort, Benjamin D. W. Belfort, Benjamin D. W. Belfort, Benjamin D. W. Belfort, Johnathan D. Jia, Johnathan D. Jia, Johnathan D. Jia, Alexandra R. Garza, Alexandra R. Garza, Alexandra R. Garza, Alexandra R. Garza, Anthony M. Insalaco, Anthony M. Insalaco, J. P. McGinnis, J. P. McGinnis, Brandon T. Pekarek, Brandon T. Pekarek, Brandon T. Pekarek, Joshua Ortiz-Guzman, Burak Tepe, Burak Tepe, Hu Chen, Hu Chen, Hu Chen, aSCENT-PD Investigators, Zhandong Liu, Zhandong Liu, Zhandong Liu, Benjamin R. Arenkiel, Benjamin R. Arenkiel, Benjamin R. Arenkiel, Benjamin R. Arenkiel, Benjamin Arenkiel, Zhandong Liu, Brit Mollenhauer, Josef Penninger, Maxime Rousseaux, Armen Saghatelyan, Natalina Salmaso, Christine Stadelmann, Michael G. Schlossmacher, Julianna J. Tomlinson, John M. Woulfe, Ying Wang, Zihong Chen, Mira Jeong   +46 more
doaj   +1 more source

Molecular cloning of an olfactory gene from Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America, 1990
G. Hasan
semanticscholar   +1 more source

Olfaction written in bone: cribriform plate size parallels olfactory receptor gene repertoires in Mammalia

Proceedings of the Royal Society B: Biological Sciences, 2018
Deborah J. Bird, W. Murphy, L. Fox-Rosales, Iman Hamid, R. Eagle, B. Van Valkenburgh   +5 more
semanticscholar   +1 more source