Results 51 to 60 of about 149,007 (299)

Disease-specific, neurosphere-derived cells as models for brain disorders [PDF]

, 2010
There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses.
Abrahamsen, G., An, J., Anderson, M., Beckhouse, A.G., Bellette, B., Bennebroek, M., Cecil, R., Chalk, A.M., Cochrane, J., Cook, A.L., Fan, Y., Féron, F., Mackay-Sim, A., Mahler, S., Matigian, N., McCurdy, R., McGrath, J.J., Mellick, G.D., Murrell, W., Nouwens, A., Perry, C., Raju, J., Ravishankar, S., Silburn, P.A., Sue, C.M., Sutharsan, R., Sutherland, G.T., Vitale, A.M., Wells, C.A., Wood, S.A.   +29 more
core   +1 more source

Update on the olfactory receptor (OR) gene superfamily [PDF]

Human Genomics, 2008
The olfactory receptor gene (OR) superfamily is the largest in the human genome. The superfamily contains 390 putatively functional genes and 465 pseudogenes arranged into 18 gene families and 300 subfamilies. Even members within the same subfamily are often located on different chromosomes.
Olender Tsviya, Lancet Doron, Nebert Daniel W   +2 more
openaire   +3 more sources

Innate Immunity in the C. elegans Intestine Is Programmed by a Neuronal Regulator of AWC Olfactory Neuron Development

Cell Reports, 2020
Summary: Olfactory neurons allow animals to discriminate nutritious food sources from potential pathogens. From a forward genetic screen, we uncovered a surprising requirement for the olfactory neuron gene olrn-1 in the regulation of intestinal ...
Kyle J. Foster, Hilary K. Cheesman, Pengpeng Liu, Nicholas D. Peterson, Sarah M. Anderson, Read Pukkila-Worley   +5 more
doaj   +1 more source

Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans. [PDF]

, 2017
In Caenorhabditis elegans, the AWC neurons are thought to deploy a cGMP signaling cascade in the detection of and response to AWC sensed odors. Prolonged exposure to an AWC sensed odor in the absence of food leads to reversible decreases in the animal's ...
BT Juang, C Peng, CI Bargmann, CM Coburn, CM Coburn, DM O’Halloran, DM O’Halloran, ER Troemel, F Paquet-Durand, H Komatsu, H Komatsu, H Zhong, H Zhong, HA Colbert, HA Colbert, HK Smith, J Bradley, J Zheng, J Zheng, JA Kaye, JF Etchberger, JI Lee, JL Krajewski, KR Kelliher, M Wojtyniak, MC Trudeau, N Blom, ND L’Etoile, O Hobert, PD Wes, PM Jenkins, S Brenner, S Kohl, S Michalakis, SW Cho, SW Cho, TK Kerppola, TY Chen, Y Song, YJ Shyu   +39 more
core   +1 more source

Identification of Structural Variation in Chimpanzees Using Optical Mapping and Nanopore Sequencing. [PDF]

, 2020
Recent efforts to comprehensively characterize great ape genetic diversity using short-read sequencing and single-nucleotide variants have led to important discoveries related to selection within species, demographic history, and lineage-specific traits.
Andrés, Aida M, Dennis, Megan Y, Kaya, Gulhan, Mastoras, Mira, Sahasrabudhe, Ruta, Schmidt, Joshua M, Shew, Colin, Soto, Daniela C   +7 more
core   +3 more sources

Localized Expression of Olfactory Receptor Genes in the Olfactory Organ of Common Minke Whales

International Journal of Molecular Sciences, 2023
Baleen whales (Mysticeti) possess the necessary anatomical structures and genetic elements for olfaction. Nevertheless, the olfactory receptor gene (OR) repertoire has undergone substantial degeneration in the cetacean lineage following the divergence of the Artiodactyla and Cetacea.
Ayumi Hirose, Masato Nikaido, Gen Nakamura, Yoshihiro Fujise, Hidehiro Kato, Takushi Kishida   +5 more
openaire   +2 more sources

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Development of a piggyBac transgenic system in Bactrocera dorsalis and its potential for research on olfactory molecular targets

Journal of Integrative Agriculture
Chemicals that modify pest behavior are developed to reduce crop damage by altering pest behavior, using specific genes within the olfactory system as molecular targets.
Jie Zhang, Qi Wang, Jinxi Yuan, Zhen Tian, Shanchun Yan, Wei Liu   +5 more
doaj   +1 more source

Parallel Multi-Gene Panel Testing for Diagnosis of Idiopathic Hypogonadotropic Hypogonadism/Kallmann Syndrome

Case Reports in Genetics, 2019
Kallmann syndrome (KS)/Idiopathic hypogonadotropic hypogonadism (IHH) is characterized by hypogonadotropic hypogonadism and anosmia or hyposmia due to the abnormal migration of olfactory and gonadotropin releasing hormone producing neurons.
Manickavasagam Senthilraja, Aaron Chapla, Felix K. Jebasingh, Dukhabhandhu Naik, Thomas V. Paul, Nihal Thomas   +5 more
doaj   +1 more source

The terminal nerve plays a prominent role in GnRH-1 neuronal migration independent from proper olfactory and vomeronasal connections to the olfactory bulbs

Biology Open, 2017
Gonadotropin-releasing hormone-1 (GnRH-1) neurons (GnRH-1 ns) migrate from the developing olfactory pit into the hypothalamus during embryonic development.
Ed Zandro M. Taroc, Aparna Prasad, Jennifer M. Lin, Paolo E. Forni   +3 more
doaj   +1 more source