Results 51 to 60 of about 7,510,662 (182)

Neurodegeneration in the olfactory bulb and olfactory deficits in the Ccdc66 -/- mouse model for retinal degeneration

IBRO Reports, 2018
The Ccdc66-deficient (Ccdc66 -/-) mouse model exhibits slow progressive retinal degeneration. It is unclear whether CCDC66 protein also plays a role in the wildtype (WT; Ccdc66 +/+) mouse brain and whether the lack of Ccdc66 gene expression in the Ccdc66
Sabrina Schreiber, Elisabeth Petrasch-Parwez, Elke Porrmann-Kelterbaum, Eckart Förster, Jörg T. Epplen, Wanda M. Gerding   +5 more
doaj   +1 more source

Convergent degeneration of olfactory receptor gene repertoires in marine mammals

BMC Genomics, 2019
Olfactory receptors (ORs) can bind odor molecules and play a crucial role in odor sensation. Due to the frequent gains and losses of genes during evolution, the number of OR members varies greatly among different species.
A. Liu, Funan He, Libing Shen, Ruixiang Liu, Zhijun Wang, Jingqi Zhou   +5 more
semanticscholar   +1 more source

Evolution of olfactory receptor genes in the human genome [PDF]

Proceedings of the National Academy of Sciences, 2003
Olfactory receptor (OR) genes form the largest known multigene family in the human genome. To obtain some insight into their evolutionary history, we have identified the complete set of OR genes and their chromosomal locations from the latest human genome sequences.
Yoshihito, Niimura, Masatoshi, Nei
openaire   +2 more sources

Anti-high mobility group box 1 antibody suppresses local inflammatory reaction and facilitates olfactory nerve recovery following injury

Journal of Neuroinflammation, 2018
Background Refractory olfactory dysfunction is a common finding in head trauma due to olfactory nerve injury. Anti-inflammatory treatment using steroids is known to contribute to functional recovery of the central and peripheral nervous systems in injury
Masayoshi Kobayashi, Kengo Tamari, Mohammed Omar Al Salihi, Kohei Nishida, Kazuhiko Takeuchi   +4 more
doaj   +1 more source

Persistent and transient olfactory deficits in COVID-19 are associated to inflammation and zinc homeostasis

Frontiers in Immunology, 2023
IntroductionThe Coronavirus Disease 2019 (COVID-19) is mainly a respiratory syndrome that can affect multiple organ systems, causing a variety of symptoms.
Lorenzo Lupi, Lorenzo Lupi, Anna Bordin, Gabriele Sales, Davide Colaianni, Adriana Vitiello, Alberto Biscontin, Alberto Reale, Alfredo Garzino-Demo, Alfredo Garzino-Demo, Angelo Antonini, Angelo Antonini, Giancarlo Ottaviano, Carla Mucignat, Cristina Parolin, Arianna Calistri, Cristiano De Pittà   +16 more
doaj   +1 more source

The Birth and Death of Olfactory Receptor Gene Families in Mammalian Niche Adaptation

Molecular biology and evolution, 2018
The olfactory receptor (OR) gene families, which govern mammalian olfaction, have undergone extensive expansion and contraction through duplication and pseudogenization.
Graham M. Hughes, Emma S. M. Boston, J. Finarelli, W. Murphy, D. Higgins, E. Teeling   +5 more
semanticscholar   +1 more source

Spatial patterns of gene expression in the olfactory bulb [PDF]

Proceedings of the National Academy of Sciences, 2004
How olfactory sensory neurons converge on spatially invariant glomeruli in the olfactory bulb is largely unknown. In one model, olfactory sensory neurons interact with spatially restricted guidance cues in the bulb that orient and guide them to their target.
David M, Lin, Yee Hwa, Yang, Jonathan A, Scolnick, Lisa J, Brunet, Heather, Marsh, Vivian, Peng, Yasushi, Okazaki, Yoshihide, Hayashizaki, Terence P, Speed, John, Ngai   +9 more
openaire   +2 more sources

Mapping transgene insertion sites reveals the α-Cre transgene expression in both developing retina and olfactory neurons

Communications Biology, 2022
The Pax6-α-Cre mouse line used in retinal studies actually contains four transgene insertion within gene clusters of olfactory and vomeronasal receptors, leading to expression in not just retinal, but also olfactory and vomeronasal sensory neurons.
Yimeng Fan, Wenyue Chen, Ran Wei, Wei Qiang, Joel D. Pearson, Tao Yu, Rod Bremner, Danian Chen   +7 more
doaj   +1 more source

Simultaneous single-cell three-dimensional genome and gene expression profiling uncovers dynamic enhancer connectivity underlying olfactory receptor choice

Nature Methods
The simultaneous measurement of three-dimensional (3D) genome structure and gene expression of individual cells is critical for understanding a genome’s structure–function relationship, yet this is challenging for existing methods.
Honggui Wu, Jiankun Zhang, F. Jian, Jinxin Phaedo Chen, Yinghui Zheng, Longzhi Tan, X. Sunney Xie   +6 more
semanticscholar   +1 more source

Acceleration of Olfactory Receptor Gene Loss in Primate Evolution: Possible Link to Anatomical Change in Sensory Systems and Dietary Transition

Molecular biology and evolution, 2018
Primates have traditionally been regarded as vision‐oriented animals with low olfactory ability, though this “microsmatic primates” view has been challenged recently.
Y. Niimura, A. Matsui, K. Touhara
semanticscholar   +1 more source