Results 41 to 50 of about 7,510,662 (182)
Singular Expression of Olfactory Receptor Genes [PDF]
Cell, 2013 Understanding the mechanisms of monogenic and monoallelic transcription of the large repertoire of olfactory receptor genes represents a challenging task. A picture is now emerging in which odorant receptor choice and stabilization involve an escape from silencing followed by the activation of an unconventional feedback loop.
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Journal of Neuroscience, 1997 The Olf-1/EBF helix-loop-helix (HLH) transcription factor has been implicated in olfactory gene regulation and in B-cell development. Using homology screening methods, we identified two additional Olf-1/EBF-like cDNAs from a mouse embryonic cDNA library.
Song S. Wang, R. Tsai, Randall R. Reed
semanticscholar +1 more source
ER stress transforms random olfactory receptor choice into axon targeting precision
Cell, 2022 Olfactory sensory neurons (OSNs) convert the stochastic choice of one out of >1000 olfactory receptor (OR) genes into precise and stereotyped axon targeting of OR-specific glomeruli in the olfactory bulb.
Hani Shayya +11 more
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Promoter architecture of mouse olfactory receptor genes [PDF]
Genome Research, 2011 Odorous chemicals are detected by the mouse main olfactory epithelium (MOE) by about 1100 types of olfactory receptors (OR) expressed by olfactory sensory neurons (OSNs). Each mature OSN is thought to express only one allele of a single OR gene. Major impediments to understand the transcriptional control of OR gene expression are the lack of a proper ...
Plessy, Charles +18 more
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Widespread ectopic expression of olfactory receptor genes [PDF]
BMC Genomics, 2006 Abstract Background Olfactory receptors (ORs) are the largest gene family in the human genome. Although they are expected to be expressed specifically in olfactory tissues, some ectopic expression has been reported, with special emphasis on sperm and testis.
Yanai Itai +5 more
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Expression of Olfactory Signaling Genes in the Eye
PLoS ONE, 2014 To advance our understanding how the outer eye interacts with its environment, we asked which cellular receptors are expressed in the cornea, focusing on G protein-coupled receptors.Total RNA from the mouse cornea was subjected to next-generation sequencing using the Illumina platform.
Alexey Pronin +5 more
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Olfactory receptor gene abundance in invasive breast carcinoma
Scientific Reports, 2019 Expression of olfactory receptors (ORs) has been reported in many human tissues outside the nasal epithelium. ORs have been validated as biomarkers in prostate cancer. In breast cancer, however, the expression and role of OR genes remain understudied. We
Shirin Masjedi, L. Zwiebel, T. Giorgio
semanticscholar +1 more source
Molecular Brain, 2019 Gene expression is highly regulated to functionally diversify cells. Genes that cooperate in the same physiological processes occasionally reside within nearby regions in a chromosome.
Noriyuki Nakashima +3 more
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Unfolding the Mystery of Olfactory Receptor Gene Expression [PDF]
Developmental Cell, 2013 Reporting recently in Cell, Dalton et al. (2013) identify a central role for the unfolded protein response in the regulation of olfactory receptor expression, unveiling molecular players in an elaborate feedback loop that controls the stabilization and establishment of single olfactory receptor gene choice.
Li, Yun Rose, Matsunami, Hiroaki
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The Role of Knockout Olfactory Receptor Genes in Odor Discrimination [PDF]
Genes, 2021 To date, little is known about the role of olfactory receptor (OR) genes on smell performance. Thanks to the availability of whole-genome sequencing data of 802 samples, we identified 41 knockout (KO) OR genes (i.e., carriers of Loss of Function variants) and evaluated their effect on odor discrimination in 218 Italian individuals through recursive ...
Concas M. P. +8 more
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