Results 61 to 70 of about 149,007 (299)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Olfactory receptor genes cooperate with protocadherin genes in human extreme obesity [PDF]

Genes & Nutrition, 2015
Worldwide, the incidence of obesity has increased dramatically over the past decades. More knowledge about the complex etiology of obesity is needed in order to find additional approaches for treatment and prevention. Investigating the exome sequencing data of 30 extremely obese subjects (BMI 45-65 kg/m(2)) shows that predicted damaging missense ...
Edwin C. M. Mariman, Radek Szklarczyk, Freek G. Bouwman, Erik E. J. G. Aller, Marleen A. van Baak, Ping Wang   +5 more
openaire   +5 more sources

The olfactory transcriptomes of mice. [PDF]

PLoS Genetics, 2014
The olfactory (OR) and vomeronasal receptor (VR) repertoires are collectively encoded by 1700 genes and pseudogenes in the mouse genome. Most OR and VR genes were identified by comparative genomic techniques and therefore, in many of those cases, only ...
Ximena Ibarra-Soria, Maria O Levitin, Luis R Saraiva, Darren W Logan   +3 more
doaj   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Mouse olfactory sensory neurons express 10,000 genes

Journal of Comparative Neurology, 2007
AbstractOlfactory epithelial cells from olfactory marker protein‐green fluorescent protein (OMP‐GFP) mice were separated by fluorescence‐activated cell sorting into a GFP+sample enriched in mature olfactory sensory neurons (OSNs) and a GFP–sample enriched in all other cells.
Neeraja, Sammeta, Tun-Tzu, Yu, Soma C, Bose, Timothy S, McClintock   +3 more
openaire   +3 more sources

Scent of COVID-19: Whole-Genome Sequencing Analysis Reveals the Role of ACE2, IFI44, and NDUFAF4 in Long-Lasting Olfactory Dysfunction

Life
COVID-19-related persistent olfactory dysfunction (OD) presents remarkable interindividual differences, and little is known about the host genetic factors that are involved in its etiopathogenesis.
Beatrice Spedicati, Alessandro Pecori, Maria Pina Concas, Aurora Santin, Romina Ruberto, Giuseppe Giovanni Nardone, Andrea D’Alessandro, Giancarlo Tirelli, Paolo Boscolo-Rizzo, Giorgia Girotto   +9 more
doaj   +1 more source

Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic

eLife, 2020
Understanding how genes and experience work in concert to generate phenotypic variability will provide a better understanding of individuality. Here, we considered this in the main olfactory epithelium, a chemosensory structure with over a thousand ...
Aashutosh Vihani, Xiaoyang Serene Hu, Sivaji Gundala, Sachiko Koyama, Eric Block, Hiroaki Matsunami   +5 more
doaj   +1 more source

Identification of the Plasticity-Relevant Fucose-α(1−2)-Galactose Proteome from the Mouse Olfactory Bulb [PDF]

, 2009
Fucose-α(1−2)-galactose [Fucα(1−2)Gal] sugars have been implicated in the molecular mechanisms that underlie neuronal development, learning, and memory. However, an understanding of their precise roles has been hampered by a lack of information regarding
Domino, Steven E., Ficarro, Scott B., Hsieh-Wilson, Linda C., Krishnamurthy, Chithra, Murrey, Heather E., Peters, Eric C.   +5 more
core   +4 more sources

Trajectory-based differential expression analysis for single-cell sequencing data [PDF]

, 2020
Trajectory inference has radically enhanced single-cell RNA-seq research by enabling the study of dynamic changes in gene expression. Downstream of trajectory inference, it is vital to discover genes that are (i) associated with the lineages in the ...
Cannoodt, Robrecht, Clement, Lieven, Dudoit, Sandrine, Roux de Bézieux, Hector, Saelens, Wouter, Saeys, Yvan, Street, Kelly, Van den Berge, Koen   +7 more
core   +2 more sources

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source