Results 261 to 270 of about 69,587 (287)
Some of the next articles are maybe not open access.
Glia, 2010
AbstractOlfactory ensheathing cells (OEC) have the ability to promote regeneration in the nervous system. Hence, they hold promise for cell therapy. Most of the experimental studies have investigated the role of OECs taken from olfactory bulb (OB). However, for a clinical human application, olfactory mucosa (OM) seems to be the only acceptable source ...
Guérout, Nicolas +6 more
openaire +3 more sources
AbstractOlfactory ensheathing cells (OEC) have the ability to promote regeneration in the nervous system. Hence, they hold promise for cell therapy. Most of the experimental studies have investigated the role of OECs taken from olfactory bulb (OB). However, for a clinical human application, olfactory mucosa (OM) seems to be the only acceptable source ...
Guérout, Nicolas +6 more
openaire +3 more sources
Journal of Alzheimer's Disease, 2022
Using an amyloid precursor protein (App) gene knock-in (KI) mouse of Alzheimer’s disease (AD), we investigated the expression of olfactory-related genes in olfactory impairment caused by AD. We observed the change in olfactory behavior in the App-KI mice.
Masataka, Narukawa +6 more
openaire +2 more sources
Using an amyloid precursor protein (App) gene knock-in (KI) mouse of Alzheimer’s disease (AD), we investigated the expression of olfactory-related genes in olfactory impairment caused by AD. We observed the change in olfactory behavior in the App-KI mice.
Masataka, Narukawa +6 more
openaire +2 more sources
Nuclear Aggregation of Olfactory Receptor Genes Governs Their Monogenic Expression [PDF]
Cell, 2012 SummaryGene positioning and regulation of nuclear architecture are thought to influence gene expression. Here, we show that, in mouse olfactory neurons, silent olfactory receptor (OR) genes from different chromosomes converge in a small number of ...
E Josephine Clowney +2 more
exaly +3 more sources
Olfactory Receptor Gene Regulation
1998The mammalian olfactory system recognizes and discriminates a vast array of odorant ligands . The number of odors that can be distinguished is on the order of tens of thousands. Recognition is accomplished, initially, by members of a family of 1000 odorant receptors. Thus the olfactory system rivals the immune system in its ability to recognize a large
openaire +2 more sources
Distribution of olfactory receptor genes in the human genome
Nature Genetics, 1998We demonstrate that members of the olfactory receptor (OR) gene family are distributed on all but a few human chromosomes. Through FISH analysis, we show that OR sequences reside at more than 25 locations in the human genome. Their distribution is biased for terminal bands.
S, Rouquier +6 more
openaire +2 more sources
Polymorphisms in olfactory receptor genes: a cautionary note
Human Immunology, 2000The hundreds of human olfactory receptor (OR) genes are organized into clusters occurring on nearly every chromosome. Although their sequences are not always closely related, they share stretches of considerable similarity, both at the amino acid and nucleotide levels.
A, Ziegler +6 more
openaire +2 more sources
Effects of olfactory bulbectomy on neuropeptide gene expression in the rat olfactory/limbic system
Neuroscience, 1998Bilateral olfactory bulbectomy in the rat produces a well-characterized syndrome that is independent of anosmia. This syndrome is reversed by chronic antidepressant administration, which provides the basis for the olfactory bulbectomy model of depression.
P V, Holmes +3 more
openaire +2 more sources
OS9: A novel olfactory gene of Drosophila expressed in two olfactory organs
Journal of Neurobiology, 1994AbstractA novel olfactory gene, OS9, has been identified in Drosophila by subtractive hybridization. OS9 transcripts have been detected in the third antennal segment, the primary olfactory organ in Drosophila, and in the maxillary palp, which has recently been shown to have olfactory function.
D, Raha, J, Carlson
openaire +2 more sources
The Loss of Olfactory Receptor Genes in Human Evolution
2007The sense of smell is mediated by olfactory receptors that bind odorants. Olfactory receptors are encoded by a large multigene family. During the evolution of primates, a large fraction of this repertoire became nonfunctional in great apes and humans. The evolution of this repertoire could reflect the evolution of the olfactory needs and ability of the
Rouquier, Sylvie, Giorgi, D.
openaire +2 more sources