Alpha-synuclein seeds in olfactory mucosa and cerebrospinal fluid of patients with dementia with Lewy bodies. [PDF]
Brain Commun, 2021 In patients with suspected dementia with Lewy bodies, the detection of the disease-associated α-synuclein in easily accessible tissues amenable to be collected using minimally invasive procedures remains a major diagnostic challenge.
Perra D +27 more
europepmc +4 more sources
Profiling of olfactory receptor gene expression in whole human olfactory mucosa. [PDF]
PLoS ONE, 2014 Olfactory perception is mediated by a large array of olfactory receptor genes. The human genome contains 851 olfactory receptor gene loci. More than 50% of the loci are annotated as nonfunctional due to frame-disrupting mutations.
Christophe Verbeurgt +5 more
doaj +6 more sources
Detection of TDP-43 seeding activity in the olfactory mucosa from patients with frontotemporal dementia. [PDF]
Alzheimers Dement, 2023 We assessed TAR DNA‐binding protein 43 (TDP‐43) seeding activity and aggregates detection in olfactory mucosa of patients with frontotemporal lobar degeneration with TDP‐43‐immunoreactive pathology (FTLD‐TDP) by TDP‐43 seeding amplification assay (TDP43 ...
Fontana E +24 more
europepmc +2 more sources
Nogo-A antibody delivery through the olfactory mucosa mitigates experimental autoimmune encephalomyelitis in the mouse CNS. [PDF]
Cell Death Discov, 2023 Systemic administration of Nogo-A-neutralizing antibody ameliorates experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis.
Pernet V +13 more
europepmc +2 more sources
Visualization and Estimation of Nasal Spray Delivery to Olfactory Mucosa in an Image-Based Transparent Nasal Model. [PDF]
Pharmaceutics, 2023 Background: Nose-to-brain (N2B) drug delivery offers unique advantages over intravenous methods; however, the delivery efficiency to the olfactory region using conventional nasal devices and protocols is low.
Seifelnasr A, Si XA, Xi J.
europepmc +2 more sources
Chronic interleukin-13 expression in mouse olfactory mucosa results in regional aneuronal epithelium. [PDF]
Int Forum Allergy Rhinol, 2023 Olfactory dysfunction is highly associated with chronic rhinosinusitis with nasal polyps (CRSwNP), and the severity of loss has been linked with biomarkers of type 2 inflammation.
Saraswathula A +3 more
europepmc +2 more sources
ACE2 downregulation in olfactory mucosa: Eosinophilic rhinosinusitis as COVID-19 protective factor? [PDF]
Allergy, 2021 Figure 1B,F) was significantly decreased in the ONE from CRSwNP. ACE2 and TMPRSS2 mRNAs were significantly decreased in the olfactory mucosa ( p < 0.05) (Figure 1G).
Marin C +7 more
europepmc +2 more sources
Selective CNS Targeting and Distribution with a Refined Region-Specific Intranasal Delivery Technique via the Olfactory Mucosa. [PDF]
Pharmaceutics, 2021 Intranasal drug delivery is a promising approach for the delivery of drugs to the CNS, but too heterogenous, unprecise delivery methods without standardization decrease the quality of many studies in rodents.
Maigler F +15 more
europepmc +2 more sources
Primary Olfactory Ensheathing Cell Culture from Human Olfactory Mucosa Specimen [PDF]
Bio-Protocol, 2017 The human olfactory mucosa is located in the middle and superior turbinates, and the septum of nasal cavity. Olfactory mucosa plays an important role in detection of odours and it is also the only nervous tissue that is exposed to the external ...
Mansoureh Hashemi +1 more
doaj +3 more sources
Extracellular vesicles derived from hypoxia-preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR-612. [PDF]
J Nanobiotechnology, 2021 Mesenchymal stem cells (MSCs) play important roles in tissue repair and regeneration, such as the induction of angiogenesis, particularly under hypoxic conditions. However, the molecular mechanisms underlying hypoxic MSC activation remain largely unknown.
Ge L +9 more
europepmc +2 more sources