Results 61 to 70 of about 16,659 (194)

SB203580, a p38MAPK inhibitor, attenuates olfactory dysfunction by inhibiting OSN apoptosis in AR mice (activation and involvement of the p38 mitogen‐activated protein kinase in olfactory sensory neuronal apoptosis of OVA‐induced allergic rhinitis)

Brain and Behavior, 2019
Objective This study aimed to investigate the effect of the p38 mitogen‐activated protein kinase (p38MAPK) signaling pathway on olfactory mucosa function and apoptosis of olfactory sensory neurons (OSNs) in an allergic rhinitis (AR) mouse model.
Xian Gao, Na Li, Jisheng Zhang
doaj   +1 more source

A Delphi Consensus on Clinical Features, Diagnosis, and Treatment of Chronic Rhinosinusitis With Nasal Polyps in the ASEAN Region

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) impacts patients' concentration, ability to work, and overall quality of life. Current treatment options include topical and oral medications, and surgery. Recent evidence supports the efficacy of biologics in improving symptoms and quality of life.
Baharudin Abdullah, Revadi Govindaraju, Salina Husain, Jin Keat Siow, Pongsakorn Tantilipikorn, Neville Wei Yang Teo, De Yun Wang, Deasi Anggraini, Tze Choong Charn, Chao‐Wu David Chin, Dichapong Kanjanawasee, Maung Maung Khaing, Jern‐Lin Leong, Luan Viet Tran, Harvinder Singh, Ing Ping Tang, Kim Thye Mark Thong, Gil M. Vicente, Yoke Yeow Yap, Soma Subramaniam   +19 more
wiley   +1 more source

Toxicological effects of volatile organic compounds are mediated by aggravated oxidative stress and neuroinflammatory processes in piglets

Toxicology Reports
Anthropogenic and natural sources of volatile organic compounds (VOCs) have been associated with hematological, cardiovascular, and respiratory diseases. VOCs can also track directly from the nose to the olfactory bulb (OB).
Evaristus Nwulia, Temitayo Olabisi Ajibade, Charles Etang Onukak, Oluwaseun Olarenwaju Esan, John Olusoji Abiola, Temidayo Olutayo Omobowale, Olanrewaju Samuel Olaifa, Olugbenga Olayinka Alaka, Olumayowa Olawumi Igado, Adedunsola Adewunmi Obasa, Godson Ana, Olubukola Christiana Omobowale, Maria Hipolito, Opeyemi Mercy Awofeso, Abimbola Idowu, Ademola Adetokunbo Oyagbemi   +15 more
doaj   +1 more source

Inflammatory Shift in Chronic Rhinosinusitis Amidst Guangzhou's Urbanization (2000–2018)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) exhibits temporal and geographic diversity in pathological endotypes with progressive eosinophilic infiltration, while the underlying causes remain unclear. Current pathological endotypes determination relies on mean cell count per high‐power field, requiring accuracy optimization.
Ning Kang, Man‐Hou Chao, Xin Luo, Feng‐Wen Shan, Zi‐Xuan Hua, Ze‐Zhi Guo, Hua‐Mei Yan, He Zhang, Tong Wu, Min Zhou, Rui Zheng, Shuo Wu, Xue‐Kun Huang, Zhao‐Hui Shi, Ya‐Na Zhang, Ji Yang, Qin‐Tai Yang   +16 more
wiley   +1 more source

Human olfactory mesenchymal stromal cells co-expressing horizontal basal and ensheathing cell proteins in culture

Biomédica: revista del Instituto Nacional de Salud, 2020
Introduction: The olfactory neuro-epithelium has an intrinsic capability of renewal during lifetime provided by the existence of globose and horizontal olfactory precursor cells.
Carlos Ayala-Grosso, Rosalinda Pieruzzini, Leslie Vargas-Saturno, José E. Cardier   +3 more
doaj   +1 more source

Ancient Schwannoma in the Nasal Cavity—A Rare Case Report With Brief Literature Review

Eye &ENT Research, EarlyView.
Shikhar Chohan, Annmy Jose, Sufian Zaheer   +2 more
wiley   +1 more source

Surgical Management of Non‐Allergic Rhinitis—An EAACI Task Force Position Paper

Allergy, EarlyView.
ABSTRACT Non‐allergic rhinitis is a frequent yet underdiagnosed cause of chronic nasal symptoms, including nasal congestion, rhinorrhoea, and upper airway hyperreactivity. Its pathophysiology involves neurogenic dysregulation, leading to excessive mucus production and vasodilation.
Marie Lundberg, Julie van Waterschoot, Mathilde Moyaert, Adam Chaker, Philippe Gevaert, Jan Hagemann, Valérie Hox, Maarten Kleijwegt, Ludger Klimek, Devyani Lal, Juan Maza‐Solano, Oliver Pfaar, Fabio Simon Ryser, Michele Shiappoli, Diana Silva, Sanna Toppila‐Salmi, Johanna Wikstén, Sietze Reitsma, Laura Van Gerven   +18 more
wiley   +1 more source

Efficacy of Full and Limited Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps: A Randomised Controlled Trial

Allergy, EarlyView.
Both Full and Limited FESS result in clinically meaningful relief of disease‐specific HRQoL and nasal breathing, effectively improving nasal symptoms and sleep disturbance in CRSwNP patients. Clinically meaningful difference in decrease of SNOT‐22 scores between the groups was not found at 12‐ and 24–month follow‐up.
P. Virkkula, S. Hammarén‐Malmi, A. Laulajainen‐Hongisto, M. Lilja, J. Wikstén, L. Hafrén, P. Kauppi, S. Reitsma, K. Pajala, J. Sahlman, S. Toppila‐Salmi   +10 more
wiley   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Anatomy of spinal CSF loss in the American alligator (Alligator mississippiensis)

Journal of Anatomy, Volume 246, Issue 4, Page 575-584, April 2025.
India ink introduced into the cranial cerebrospinal fluid (CSF) compartment of Alligator diffuses along the spinal cord and exits the spinal compartment using perineural flow, resulting in a prominent “ink cuff” forming at the base of the spinal nerve. In Alligator, the region of the ink cuff is drained by a small lymphatic vessel.
Hadyn DeLeeuw, Michael Cramberg, Matthew Dille, Emily Pick, Mary Thompson, Bruce A. Young   +5 more
wiley   +1 more source