Results 81 to 90 of about 16,659 (194)

Isolation and characterization of olfactory stem cells from canine olfactory mucosa

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2016
Olfactory stem cells have great potential in the treatment of neurodegenerative diseases and they are good candidates for cell therapy due to the easy accessibility of olfactory mucosa. The main objectives of this study were isolation, proliferation and characterization of olfactory mucosa stem cells that were further differentiated into olfactory ...
Altunbas, Korhan, Yaprakci, Mustafa Volkan, Celik, Sefa   +2 more
openaire   +3 more sources

Dosing Interval Extension of Dupilumab in CRSwNP: Five‐Year Real World Outcomes

International Forum of Allergy &Rhinology, Volume 16, Issue 8, Page 797-808, August 2026.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent, often Type 2‐mediated inflammatory disease that markedly impairs quality of life. While dupilumab provides rapid improvement, there is limited evidence on long‐term outcomes beyond 2 years, and the clinical impact of dosing‐interval extension remains unclear.
Nicholas J. Campion, Dioni‐Pinelopi Petsiou, Florian C. Fally, Karina Berbalk, Noah F. Melamed, Aldine Tu, Christina Morgenstern, Fana Alem Kidane, Mohammed Zghaebi, Linda Liu, Minghao Pan, Tina J. Bartosik, Victoria Stanek, Katarina Gangl, Julia Eckl‐Dorna, Sven Schneider   +15 more
wiley   +1 more source

Systemic Corticosteroids in the Management of Sinonasal Disease: An Evidence‐Based Expert Review

International Forum of Allergy &Rhinology, Volume 16, Issue 8, Page 852-879, August 2026.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a prevalent, heterogeneous inflammatory disease associated with significant morbidity. Systemic corticosteroids (SCS) are commonly prescribed for their anti‐inflammatory effects, but cumulative exposure carries risks, including metabolic, cardiovascular, and skeletal complications.
Andrew Thamboo, Deanna Gigliotti, Eugenio De Corso, Stella Lee, Benjamin S. Bleier, Christopher J. Chin, Marie‐Noelle Corriveau, Valerie Hox, Claire Hopkins, Peter H. Hwang, Arif Janjua, Ludger Klimek, Daniel Lee, John Lee, Amber Luong, Geoffrey Mortuaire, Joaquim Mullol, Zara M. Patel, John Scott, Doron Sommer, Leigh Sowerby, Marc Tewfik, Beatrice Voizard, Martin Wagenmannm, Sarah K. Wise, Jonathan Yip, Quirina Thompson, Martin Desrosiers, Yvonne Chan   +28 more
wiley   +1 more source

Microsurgical anatomy of the olfactory filaments in the nasal mucosa

Journal of Neurosurgery
OBJECTIVE The aim of this study was to examine the distribution of olfactory filaments (OFs) in the nasal mucosa to facilitate preservation of olfactory function in endonasal approaches and preparation of a nasoseptal flap. METHODS One formalin-fixed and 9 fresh cadaveric silicone-injected specimens with 20 total sides were studied to measure the ...
Ilgaz, Hasan Baris, Urgun, Kamran, Yener, Ulas, Mut, Melike, Liu, James K., Yagmurlu, Kaan   +5 more
openaire   +3 more sources

Exosomal TGM2 From Hypoxia‐Primed Olfactory Mucosa MSCs Attenuates Senescent Astrocytes via NRF1/TFAM Signaling in Parkinson's Disease

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Hypoxia‐preconditioned olfactory mucosa mesenchymal stem cells (OM‐MSCs) release exosomes enriched with transglutaminase 2 (TGM2), which are taken up by astrocytes. Inside the nucleus, TGM2 activates NRF1, leading to the upregulation of TFAM. This enhances mitochondrial function by reducing mitochondrial DNA (mtDNA) leakage and improving mitochondrial ...
Xiqi Hu, Yuchang Liang, Hong Fan, Wenqi Fan, Zijie Wang, Ya‐nan Ma, Peipei Song, Ying Xia   +7 more
wiley   +1 more source

Associations between ICU survival and self‐perceived appetite, smell, and taste relative to general ward patients: A prospective study

Journal of Parenteral and Enteral Nutrition, Volume 50, Issue 6, Page 805-815, August 2026.
Abstract Background Post‐intensive care unit (ICU) patients frequently fail to meet nutritional requirements during recovery on the hospital ward. Alterations in appetite, smell and taste perception in ICU survivors remain poorly understood. This study compared appetite and sensory perceptions between ICU survivors and general ward patients and ...
Max Melchers, Julia C. J. Loenen, Elbrich M. Wempe, Arthur R. H. van Zanten, Imre W. K. Kouw   +4 more
wiley   +1 more source

Olfactory‐Related Quality of Life After Endoscopic Transsphenoidal Surgery

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
The QOD‐LQ, QOD‐VAS, and the “decreased sense of smell” item of the SNOT‐22, reflecting olfactory‐related quality of life (QOL) and subjective olfactory dysfunction, significantly deteriorated after EETSA in a substantial proportion of patients, even though psychophysical olfactory function was preserved.
Yeong Ju Lee, Jeong Heon Kim, Chang‐Ki Hong, Young‐Hoon Kim, Ji Heui Kim   +4 more
wiley   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, Volume 104, Issue 5, Page e478-e490, August 2026.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6509-6532, August 2026.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

Systematic review of literature regarding the isolation of mesenchymal adult stem cells from the olfactory epithelium

Frontiers in Cellular Neuroscience
BackgroundThe olfactory mucosa has emerged as a promising source of mesenchymal stem cells with neurogenic potential. These cells exhibit neural, glial, and mesenchymal properties, making them attractive candidates for regenerative medicine, particularly
Carlotta Pipolo, Paula La Rubia, Anna Cozzi, Preetha Karki, Alberto Maria Saibene, Daniele Bottai   +5 more
doaj   +1 more source